Extracellular ATP Induced S-Phase Cell Cycle Arrest via P2Y Receptor-Activated ERK Signaling in Poorly Differentiated Oral Squamous Cell Carcinoma SAS Cells

Extracellular ATP Induced S-Phase Cell Cycle Arrest via P2Y Receptor-Activated ERK Signaling in Poorly Differentiated Oral Squamous Cell Carcinoma SAS Cells

Extracellular ATP in the tumor microenvironment exhibits either pro- or antitumor effect via interaction with P2Y receptors, but the intracellular signaling and functional roles of P2Y receptors in oral squamous cell carcinoma (OSCC) are unclear. We aimed to study the effect of ATP on OSCC cell line...

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Autores principales: Chia Chih Lau, Amnani Aminuddin, Kok Meng Chan, Ian C. Paterson, Lok Mun Law, Pei Yuen Ng
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
extracellular ATP
oral squamous cell carcinoma
P2Y receptors
ERK signaling
S-phase arrest
Science
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Acceso en línea:https://doaj.org/article/ff61f319a17142b095effa1ebf562787
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