Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma

Recent studies have identified a number of oncogenic histone point mutations in different cancers. Here the authors provide evidence that H3.3 G34R substitution mutation, which is found in paediatric gliomas, causes changes in H3K9me3 and H3K36me3 by interfering with the KDM4 family of K9/K36 demeth...

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Autores principales:	Hsiao P. J. Voon, Maheshi Udugama, Wendi Lin, Linda Hii, Ruby H.P. Law, David L. Steer, Partha P. Das, Jeffrey R. Mann, Lee H. Wong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ff6360735a0f4f9897f784eabad7f170
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spelling	oai:doaj.org-article:ff6360735a0f4f9897f784eabad7f1702021-12-02T16:50:12ZInhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma10.1038/s41467-018-05607-52041-1723https://doaj.org/article/ff6360735a0f4f9897f784eabad7f1702018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05607-5https://doaj.org/toc/2041-1723Recent studies have identified a number of oncogenic histone point mutations in different cancers. Here the authors provide evidence that H3.3 G34R substitution mutation, which is found in paediatric gliomas, causes changes in H3K9me3 and H3K36me3 by interfering with the KDM4 family of K9/K36 demethylases.Hsiao P. J. VoonMaheshi UdugamaWendi LinLinda HiiRuby H.P. LawDavid L. SteerPartha P. DasJeffrey R. MannLee H. WongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hsiao P. J. Voon Maheshi Udugama Wendi Lin Linda Hii Ruby H.P. Law David L. Steer Partha P. Das Jeffrey R. Mann Lee H. Wong Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma
description	Recent studies have identified a number of oncogenic histone point mutations in different cancers. Here the authors provide evidence that H3.3 G34R substitution mutation, which is found in paediatric gliomas, causes changes in H3K9me3 and H3K36me3 by interfering with the KDM4 family of K9/K36 demethylases.
format	article
author	Hsiao P. J. Voon Maheshi Udugama Wendi Lin Linda Hii Ruby H.P. Law David L. Steer Partha P. Das Jeffrey R. Mann Lee H. Wong
author_facet	Hsiao P. J. Voon Maheshi Udugama Wendi Lin Linda Hii Ruby H.P. Law David L. Steer Partha P. Das Jeffrey R. Mann Lee H. Wong
author_sort	Hsiao P. J. Voon
title	Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma
title_short	Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma
title_full	Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma
title_fullStr	Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma
title_full_unstemmed	Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma
title_sort	inhibition of a k9/k36 demethylase by an h3.3 point mutation found in paediatric glioblastoma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ff6360735a0f4f9897f784eabad7f170
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Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma

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