Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma

Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma

Recent studies have identified a number of oncogenic histone point mutations in different cancers. Here the authors provide evidence that H3.3 G34R substitution mutation, which is found in paediatric gliomas, causes changes in H3K9me3 and H3K36me3 by interfering with the KDM4 family of K9/K36 demeth...

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Autores principales: Hsiao P. J. Voon, Maheshi Udugama, Wendi Lin, Linda Hii, Ruby H.P. Law, David L. Steer, Partha P. Das, Jeffrey R. Mann, Lee H. Wong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/ff6360735a0f4f9897f784eabad7f170
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