Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia

Delivering biological cargo to airway epithelial cells is very challenging. Here, the authors use engineered amphiphilic peptides to shuttle proteins and CRISPR RNPs into airway cells in vivo.

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Autores principales:	Sateesh Krishnamurthy, Christine Wohlford-Lenane, Suhas Kandimalla, Gilles Sartre, David K. Meyerholz, Vanessa Théberge, Stéphanie Hallée, Anne-Marie Duperré, Thomas Del’Guidice, Jean-Pascal Lepetit-Stoffaes, Xavier Barbeau, David Guay, Paul B. McCray
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ff65627fb12a41acbe88df2dd58937e2
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spelling	oai:doaj.org-article:ff65627fb12a41acbe88df2dd58937e22021-12-02T14:39:20ZEngineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia10.1038/s41467-019-12922-y2041-1723https://doaj.org/article/ff65627fb12a41acbe88df2dd58937e22019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12922-yhttps://doaj.org/toc/2041-1723Delivering biological cargo to airway epithelial cells is very challenging. Here, the authors use engineered amphiphilic peptides to shuttle proteins and CRISPR RNPs into airway cells in vivo.Sateesh KrishnamurthyChristine Wohlford-LenaneSuhas KandimallaGilles SartreDavid K. MeyerholzVanessa ThébergeStéphanie HalléeAnne-Marie DuperréThomas Del’GuidiceJean-Pascal Lepetit-StoffaesXavier BarbeauDavid GuayPaul B. McCrayNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sateesh Krishnamurthy Christine Wohlford-Lenane Suhas Kandimalla Gilles Sartre David K. Meyerholz Vanessa Théberge Stéphanie Hallée Anne-Marie Duperré Thomas Del’Guidice Jean-Pascal Lepetit-Stoffaes Xavier Barbeau David Guay Paul B. McCray Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia
description	Delivering biological cargo to airway epithelial cells is very challenging. Here, the authors use engineered amphiphilic peptides to shuttle proteins and CRISPR RNPs into airway cells in vivo.
format	article
author	Sateesh Krishnamurthy Christine Wohlford-Lenane Suhas Kandimalla Gilles Sartre David K. Meyerholz Vanessa Théberge Stéphanie Hallée Anne-Marie Duperré Thomas Del’Guidice Jean-Pascal Lepetit-Stoffaes Xavier Barbeau David Guay Paul B. McCray
author_facet	Sateesh Krishnamurthy Christine Wohlford-Lenane Suhas Kandimalla Gilles Sartre David K. Meyerholz Vanessa Théberge Stéphanie Hallée Anne-Marie Duperré Thomas Del’Guidice Jean-Pascal Lepetit-Stoffaes Xavier Barbeau David Guay Paul B. McCray
author_sort	Sateesh Krishnamurthy
title	Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia
title_short	Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia
title_full	Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia
title_fullStr	Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia
title_full_unstemmed	Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia
title_sort	engineered amphiphilic peptides enable delivery of proteins and crispr-associated nucleases to airway epithelia
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ff65627fb12a41acbe88df2dd58937e2
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Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia

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