Genetic overlap and causal associations between smoking behaviours and mental health

Abstract Cigarette smoking is a modifiable behaviour associated with mental health. We investigated the degree of genetic overlap between smoking behaviours and psychiatric traits and disorders, and whether genetic associations exist beyond genetic influences shared with confounding variables (canna...

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Autores principales:	Wikus Barkhuizen, Frank Dudbridge, Angelica Ronald
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ff67fcdb312a4ff3b3aa8960752f64d2
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spelling	oai:doaj.org-article:ff67fcdb312a4ff3b3aa8960752f64d22021-12-02T17:55:03ZGenetic overlap and causal associations between smoking behaviours and mental health10.1038/s41598-021-93962-72045-2322https://doaj.org/article/ff67fcdb312a4ff3b3aa8960752f64d22021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93962-7https://doaj.org/toc/2045-2322Abstract Cigarette smoking is a modifiable behaviour associated with mental health. We investigated the degree of genetic overlap between smoking behaviours and psychiatric traits and disorders, and whether genetic associations exist beyond genetic influences shared with confounding variables (cannabis and alcohol use, risk-taking and insomnia). Second, we investigated the presence of causal associations between smoking initiation and psychiatric traits and disorders. We found significant genetic correlations between smoking and psychiatric disorders and adult psychotic experiences. When genetic influences on known covariates were controlled for, genetic associations between most smoking behaviours and schizophrenia and depression endured (but not with bipolar disorder or most psychotic experiences). Mendelian randomization results supported a causal role of smoking initiation on psychiatric disorders and adolescent cognitive and negative psychotic experiences, although not consistently across all sensitivity analyses. In conclusion, smoking and psychiatric disorders share genetic influences that cannot be attributed to covariates such as risk-taking, insomnia or other substance use. As such, there may be some common genetic pathways underlying smoking and psychiatric disorders. In addition, smoking may play a causal role in vulnerability for mental illness.Wikus BarkhuizenFrank DudbridgeAngelica RonaldNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wikus Barkhuizen Frank Dudbridge Angelica Ronald Genetic overlap and causal associations between smoking behaviours and mental health
description	Abstract Cigarette smoking is a modifiable behaviour associated with mental health. We investigated the degree of genetic overlap between smoking behaviours and psychiatric traits and disorders, and whether genetic associations exist beyond genetic influences shared with confounding variables (cannabis and alcohol use, risk-taking and insomnia). Second, we investigated the presence of causal associations between smoking initiation and psychiatric traits and disorders. We found significant genetic correlations between smoking and psychiatric disorders and adult psychotic experiences. When genetic influences on known covariates were controlled for, genetic associations between most smoking behaviours and schizophrenia and depression endured (but not with bipolar disorder or most psychotic experiences). Mendelian randomization results supported a causal role of smoking initiation on psychiatric disorders and adolescent cognitive and negative psychotic experiences, although not consistently across all sensitivity analyses. In conclusion, smoking and psychiatric disorders share genetic influences that cannot be attributed to covariates such as risk-taking, insomnia or other substance use. As such, there may be some common genetic pathways underlying smoking and psychiatric disorders. In addition, smoking may play a causal role in vulnerability for mental illness.
format	article
author	Wikus Barkhuizen Frank Dudbridge Angelica Ronald
author_facet	Wikus Barkhuizen Frank Dudbridge Angelica Ronald
author_sort	Wikus Barkhuizen
title	Genetic overlap and causal associations between smoking behaviours and mental health
title_short	Genetic overlap and causal associations between smoking behaviours and mental health
title_full	Genetic overlap and causal associations between smoking behaviours and mental health
title_fullStr	Genetic overlap and causal associations between smoking behaviours and mental health
title_full_unstemmed	Genetic overlap and causal associations between smoking behaviours and mental health
title_sort	genetic overlap and causal associations between smoking behaviours and mental health
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ff67fcdb312a4ff3b3aa8960752f64d2
work_keys_str_mv	AT wikusbarkhuizen geneticoverlapandcausalassociationsbetweensmokingbehavioursandmentalhealth AT frankdudbridge geneticoverlapandcausalassociationsbetweensmokingbehavioursandmentalhealth AT angelicaronald geneticoverlapandcausalassociationsbetweensmokingbehavioursandmentalhealth
_version_	1718379207687405568

Genetic overlap and causal associations between smoking behaviours and mental health

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