Metformin action over gut microbiota is related to weight and glycemic control in gestational diabetes mellitus: A randomized trial

Background: Metformin, which is known to produce profound changes in gut microbiota, is being increasingly used in gestational diabetes mellitus (GDM). The aim of this study was to elucidate the differences in gut microbiota composition and function in women with GDM treated with metformin compared...

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Autores principales:	María Molina-Vega, María J. Picón-César, Carolina Gutiérrez-Repiso, Andrea Fernández-Valero, Fuensanta Lima-Rubio, Stella González-Romero, Isabel Moreno-Indias, Francisco J. Tinahones
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Gestational diabetes Metformin Insulin Gut microbiota Weight gain Metabolic control Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ff6ab387edbf4bb9adea2651aba7194f
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spelling	oai:doaj.org-article:ff6ab387edbf4bb9adea2651aba7194f2021-11-28T04:28:27ZMetformin action over gut microbiota is related to weight and glycemic control in gestational diabetes mellitus: A randomized trial0753-332210.1016/j.biopha.2021.112465https://doaj.org/article/ff6ab387edbf4bb9adea2651aba7194f2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221012518https://doaj.org/toc/0753-3322Background: Metformin, which is known to produce profound changes in gut microbiota, is being increasingly used in gestational diabetes mellitus (GDM). The aim of this study was to elucidate the differences in gut microbiota composition and function in women with GDM treated with metformin compared to those treated with insulin. Methods: From May to December 2018, 58 women with GDM were randomized to receive insulin (INS; n = 28) or metformin (MET; n = 30) at the University Hospital Virgen de la Victoria, Málaga, Spain. Basal visits, with at least 1 follow-up visit and prepartum visit, were performed. At the basal and prepartum visits, blood and stool samples were collected. The gut microbiota profile was determined through 16S rRNA analysis. Results: Compared to INS, women on MET presented a lower mean postprandial glycemia and a lower increase in weight and body mass index (BMI). Firmicutes and Peptostreptococcaceae abundance declined, while Proteobacteria and Enterobacteriaceae abundance increased in the MET group. We found inverse correlations between changes in the abundance of Proteobacteria and mean postprandial glycemia (p = 0.023), as well as between Enterobacteriaceae and a rise in BMI and weight gain (p = 0.031 and p = 0.036, respectively). Regarding the metabolic profile of gut microbiota, predicted metabolic pathways related to propionate degradation and ubiquinol biosynthesis predominated in the MET group. Conclusion: Metformin in GDM affects the composition and metabolic profile of gut microbiota. These changes could mediate, at least in part, its clinical effects. Studies designed to assess how these changes influence metabolic control during and after pregnancy are necessary.María Molina-VegaMaría J. Picón-CésarCarolina Gutiérrez-RepisoAndrea Fernández-ValeroFuensanta Lima-RubioStella González-RomeroIsabel Moreno-IndiasFrancisco J. TinahonesElsevierarticleGestational diabetesMetforminInsulinGut microbiotaWeight gainMetabolic controlTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112465- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gestational diabetes Metformin Insulin Gut microbiota Weight gain Metabolic control Therapeutics. Pharmacology RM1-950
spellingShingle	Gestational diabetes Metformin Insulin Gut microbiota Weight gain Metabolic control Therapeutics. Pharmacology RM1-950 María Molina-Vega María J. Picón-César Carolina Gutiérrez-Repiso Andrea Fernández-Valero Fuensanta Lima-Rubio Stella González-Romero Isabel Moreno-Indias Francisco J. Tinahones Metformin action over gut microbiota is related to weight and glycemic control in gestational diabetes mellitus: A randomized trial
description	Background: Metformin, which is known to produce profound changes in gut microbiota, is being increasingly used in gestational diabetes mellitus (GDM). The aim of this study was to elucidate the differences in gut microbiota composition and function in women with GDM treated with metformin compared to those treated with insulin. Methods: From May to December 2018, 58 women with GDM were randomized to receive insulin (INS; n = 28) or metformin (MET; n = 30) at the University Hospital Virgen de la Victoria, Málaga, Spain. Basal visits, with at least 1 follow-up visit and prepartum visit, were performed. At the basal and prepartum visits, blood and stool samples were collected. The gut microbiota profile was determined through 16S rRNA analysis. Results: Compared to INS, women on MET presented a lower mean postprandial glycemia and a lower increase in weight and body mass index (BMI). Firmicutes and Peptostreptococcaceae abundance declined, while Proteobacteria and Enterobacteriaceae abundance increased in the MET group. We found inverse correlations between changes in the abundance of Proteobacteria and mean postprandial glycemia (p = 0.023), as well as between Enterobacteriaceae and a rise in BMI and weight gain (p = 0.031 and p = 0.036, respectively). Regarding the metabolic profile of gut microbiota, predicted metabolic pathways related to propionate degradation and ubiquinol biosynthesis predominated in the MET group. Conclusion: Metformin in GDM affects the composition and metabolic profile of gut microbiota. These changes could mediate, at least in part, its clinical effects. Studies designed to assess how these changes influence metabolic control during and after pregnancy are necessary.
format	article
author	María Molina-Vega María J. Picón-César Carolina Gutiérrez-Repiso Andrea Fernández-Valero Fuensanta Lima-Rubio Stella González-Romero Isabel Moreno-Indias Francisco J. Tinahones
author_facet	María Molina-Vega María J. Picón-César Carolina Gutiérrez-Repiso Andrea Fernández-Valero Fuensanta Lima-Rubio Stella González-Romero Isabel Moreno-Indias Francisco J. Tinahones
author_sort	María Molina-Vega
title	Metformin action over gut microbiota is related to weight and glycemic control in gestational diabetes mellitus: A randomized trial
title_short	Metformin action over gut microbiota is related to weight and glycemic control in gestational diabetes mellitus: A randomized trial
title_full	Metformin action over gut microbiota is related to weight and glycemic control in gestational diabetes mellitus: A randomized trial
title_fullStr	Metformin action over gut microbiota is related to weight and glycemic control in gestational diabetes mellitus: A randomized trial
title_full_unstemmed	Metformin action over gut microbiota is related to weight and glycemic control in gestational diabetes mellitus: A randomized trial
title_sort	metformin action over gut microbiota is related to weight and glycemic control in gestational diabetes mellitus: a randomized trial
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/ff6ab387edbf4bb9adea2651aba7194f
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Metformin action over gut microbiota is related to weight and glycemic control in gestational diabetes mellitus: A randomized trial

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