Comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia

Abstract Existing studies on cognitive impairments in chronic pain do not investigate peripheral neuropathic pain (PNP) or compare pain conditions in a satisfactory manner. Here we aimed to compare executive dysfunctions in PNP patients with fibromyalgia (FM) and healthy controls (HC). Patients who...

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Autores principales:	Henrik Børsting Jacobsen, Tore C. Stiles, Audun Stubhaug, Nils Inge Landrø, Per Hansson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ff6c5848a3aa4f92b83907cce3b21acb
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spelling	oai:doaj.org-article:ff6c5848a3aa4f92b83907cce3b21acb2021-12-02T15:23:05ZComparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia10.1038/s41598-020-80740-02045-2322https://doaj.org/article/ff6c5848a3aa4f92b83907cce3b21acb2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80740-0https://doaj.org/toc/2045-2322Abstract Existing studies on cognitive impairments in chronic pain do not investigate peripheral neuropathic pain (PNP) or compare pain conditions in a satisfactory manner. Here we aimed to compare executive dysfunctions in PNP patients with fibromyalgia (FM) and healthy controls (HC). Patients who self-reported cognitive impairments were assessed according to criteria for PNP or FM. Seventy-three patients met criteria and completed testing on executive functioning and IQ measures. We also included twenty matched healthy controls. Regression models controlling for age, sex and IQ, tested associations between group category (PNP, FM or HC) and outcomes. If a substantial association was detected, we followed up with head-to-head comparisons between PNP and FM. Multivariate regression models then tested associations between executive functioning and pain type, controlling for significant confounders. Results from head-to-head comparison between pain conditions showed significant differences on years lived with pain (FM > PNP), the use of anticonvulsants (PNP > FM) and use of analgesics (PNP > FM). When controlled for all significant differences, PNP patients had significantly lower scores on an attention-demanding cued-recall task compared to FM. Poor performance on attention-demanding cued-recall task was associated with PNP, which translate into problems with retaining fast-pace or advanced information.Henrik Børsting JacobsenTore C. StilesAudun StubhaugNils Inge LandrøPer HanssonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Henrik Børsting Jacobsen Tore C. Stiles Audun Stubhaug Nils Inge Landrø Per Hansson Comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia
description	Abstract Existing studies on cognitive impairments in chronic pain do not investigate peripheral neuropathic pain (PNP) or compare pain conditions in a satisfactory manner. Here we aimed to compare executive dysfunctions in PNP patients with fibromyalgia (FM) and healthy controls (HC). Patients who self-reported cognitive impairments were assessed according to criteria for PNP or FM. Seventy-three patients met criteria and completed testing on executive functioning and IQ measures. We also included twenty matched healthy controls. Regression models controlling for age, sex and IQ, tested associations between group category (PNP, FM or HC) and outcomes. If a substantial association was detected, we followed up with head-to-head comparisons between PNP and FM. Multivariate regression models then tested associations between executive functioning and pain type, controlling for significant confounders. Results from head-to-head comparison between pain conditions showed significant differences on years lived with pain (FM > PNP), the use of anticonvulsants (PNP > FM) and use of analgesics (PNP > FM). When controlled for all significant differences, PNP patients had significantly lower scores on an attention-demanding cued-recall task compared to FM. Poor performance on attention-demanding cued-recall task was associated with PNP, which translate into problems with retaining fast-pace or advanced information.
format	article
author	Henrik Børsting Jacobsen Tore C. Stiles Audun Stubhaug Nils Inge Landrø Per Hansson
author_facet	Henrik Børsting Jacobsen Tore C. Stiles Audun Stubhaug Nils Inge Landrø Per Hansson
author_sort	Henrik Børsting Jacobsen
title	Comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia
title_short	Comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia
title_full	Comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia
title_fullStr	Comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia
title_full_unstemmed	Comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia
title_sort	comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ff6c5848a3aa4f92b83907cce3b21acb
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Comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia

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