Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review

Omar Abdifetah,1,2 Kesara Na-Bangchang1–31Graduate Studies, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand; 2Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of...

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Autores principales:	Abdifetah O, Na-Bangchang K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Anticancer Chemotherapy Herb-derived compounds Nanoparticles Pharmacokinetics Traditional medicines Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ff6f8ba4500f447fa760ec8c1b54f8c1
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spelling	oai:doaj.org-article:ff6f8ba4500f447fa760ec8c1b54f8c12021-12-02T02:50:31ZPharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review1178-2013https://doaj.org/article/ff6f8ba4500f447fa760ec8c1b54f8c12019-07-01T00:00:00Zhttps://www.dovepress.com/pharmacokinetic-studies-of-nanoparticles-as-a-delivery-system-for-conv-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Omar Abdifetah,1,2 Kesara Na-Bangchang1–31Graduate Studies, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand; 2Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand; 3Drug Discovery Center, Thammasat University, Pathumthani, ThailandAbstract: The poor pharmacokinetic characteristics of most anticancer drugs have limited their clinical effectiveness. The application of nanoparticles as a novel drug delivery system has provided opportunities to tackle the current challenges facing conventional drug delivery systems such as poor pharmacokinetics, lack of specificity to tumor cells, multidrug resistance, and toxicity. This systematic review aims to examine the application of pharmacokinetic studies of nanoparticles loaded in conventional drugs and herb-derived compounds for cancer therapy. The pharmacokinetic parameters of several herbal medicines and chemotherapeutic drugs loaded into nanoparticles were reported. This included area under the curve (AUC) of plasma concentration–time profile, maximum plasma concentration (Cmax), time to maximum plasma concentration (Tmax), volume of distribution (Vd or Vss), elimination half-life (t½), and clearance (CL). The systematic review was conducted using information available in the PubMed and Science Direct databases up to February 2019. The search terms employed were: pharmacokinetics, pharmacokinetic study, nanoparticles, anticancer, traditional medicine, herbal medicine, herb-derived compounds, natural products, and chemotherapy. Overall, nanoparticle carriers not only significantly improved pharmacokinetics but also further enhanced permeability, solubility, stability, specificity, and selectivity of the carried anticancer drugs/herb-derived compounds to target tumor cells. Additionally, they also limited hepatic first-pass metabolism and P-glycoprotein (P-gp) efflux of the carried anticancer drugs/herb-derived compounds. Based on this systematic review, polymeric nanoparticles were the most commonly used nanocarrier to improve the pharmacokinetic parameters. The use of nanoparticles as a novel drug delivery system has the potential to improve both pharmacokinetics and cytotoxicity activity of the loaded drugs/herb-derived compounds for cancer therapy.Keywords: anticancer, chemotherapy, herb-derived compounds, nanoparticles, pharmacokinetics, traditional medicinesAbdifetah ONa-Bangchang KDove Medical PressarticleAnticancerChemotherapyHerb-derived compoundsNanoparticles PharmacokineticsTraditional medicinesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 5659-5677 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Anticancer Chemotherapy Herb-derived compounds Nanoparticles Pharmacokinetics Traditional medicines Medicine (General) R5-920
spellingShingle	Anticancer Chemotherapy Herb-derived compounds Nanoparticles Pharmacokinetics Traditional medicines Medicine (General) R5-920 Abdifetah O Na-Bangchang K Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review
description	Omar Abdifetah,1,2 Kesara Na-Bangchang1–31Graduate Studies, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand; 2Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand; 3Drug Discovery Center, Thammasat University, Pathumthani, ThailandAbstract: The poor pharmacokinetic characteristics of most anticancer drugs have limited their clinical effectiveness. The application of nanoparticles as a novel drug delivery system has provided opportunities to tackle the current challenges facing conventional drug delivery systems such as poor pharmacokinetics, lack of specificity to tumor cells, multidrug resistance, and toxicity. This systematic review aims to examine the application of pharmacokinetic studies of nanoparticles loaded in conventional drugs and herb-derived compounds for cancer therapy. The pharmacokinetic parameters of several herbal medicines and chemotherapeutic drugs loaded into nanoparticles were reported. This included area under the curve (AUC) of plasma concentration–time profile, maximum plasma concentration (Cmax), time to maximum plasma concentration (Tmax), volume of distribution (Vd or Vss), elimination half-life (t½), and clearance (CL). The systematic review was conducted using information available in the PubMed and Science Direct databases up to February 2019. The search terms employed were: pharmacokinetics, pharmacokinetic study, nanoparticles, anticancer, traditional medicine, herbal medicine, herb-derived compounds, natural products, and chemotherapy. Overall, nanoparticle carriers not only significantly improved pharmacokinetics but also further enhanced permeability, solubility, stability, specificity, and selectivity of the carried anticancer drugs/herb-derived compounds to target tumor cells. Additionally, they also limited hepatic first-pass metabolism and P-glycoprotein (P-gp) efflux of the carried anticancer drugs/herb-derived compounds. Based on this systematic review, polymeric nanoparticles were the most commonly used nanocarrier to improve the pharmacokinetic parameters. The use of nanoparticles as a novel drug delivery system has the potential to improve both pharmacokinetics and cytotoxicity activity of the loaded drugs/herb-derived compounds for cancer therapy.Keywords: anticancer, chemotherapy, herb-derived compounds, nanoparticles, pharmacokinetics, traditional medicines
format	article
author	Abdifetah O Na-Bangchang K
author_facet	Abdifetah O Na-Bangchang K
author_sort	Abdifetah O
title	Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review
title_short	Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review
title_full	Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review
title_fullStr	Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review
title_full_unstemmed	Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review
title_sort	pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/ff6f8ba4500f447fa760ec8c1b54f8c1
work_keys_str_mv	AT abdifetaho pharmacokineticstudiesofnanoparticlesasadeliverysystemforconventionaldrugsandherbderivedcompoundsforcancertherapyasystematicreview AT nabangchangk pharmacokineticstudiesofnanoparticlesasadeliverysystemforconventionaldrugsandherbderivedcompoundsforcancertherapyasystematicreview
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Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review

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