Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years

Khalid Hussain AL-Qahtani,1 Mutahir A Tunio,2 Mushabbab Al Asiri,2 Yasser Bayoumi,3 Ali Balbaid,2 Naji J Aljohani,4 Hanadi Fatani5 1Department of Otolaryngology-Head & Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2Department of Radiation Oncology, Comprehen...

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Autores principales:	AL-Qahtani KH, Tunio MA, Asiri MA, Bayoumi Y, Balbaid A, Aljohani NJ, Fatani H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Differentiated thyroid cancers patients aged above 45 years aged above 60 years age below 60 years clinicopathological characteristics treatment outcomes elderly patients. comparative analysis Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/ff6fa28af47843d2b0fe0b45c897b11f
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spelling	oai:doaj.org-article:ff6fa28af47843d2b0fe0b45c897b11f2021-12-02T01:05:22ZComparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years1178-1998https://doaj.org/article/ff6fa28af47843d2b0fe0b45c897b11f2016-08-01T00:00:00Zhttps://www.dovepress.com/comparative-clinicopathological-and-outcome-analysis-of-differentiated-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Khalid Hussain AL-Qahtani,1 Mutahir A Tunio,2 Mushabbab Al Asiri,2 Yasser Bayoumi,3 Ali Balbaid,2 Naji J Aljohani,4 Hanadi Fatani5 1Department of Otolaryngology-Head & Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2Department of Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, Saudi Arabia; 3Department of Radiation Oncology, NCI, Cairo University, Cairo, Egypt; 4Department of Endocrinology and Thyroid Oncology, 5Histopathology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, Saudi Arabia Introduction: The aim of this study was to evaluate the treatment outcomes of differentiated thyroid cancer in Saudi patients aged above 60 years. Materials and methods: Comparative analysis was performed in 252 patients aged 46–60 years (Group A) and 118 patients aged above 60 years (Group B), who had thyroidectomy, radioactive iodine-131, and thyroid-stimulating hormone suppression therapy between July 2000 and December 2012. Different clinicopathological features, treatment, complications, disease-free survival, and overall survival rates were compared. Results: Mean age of patients in Group A was 51.9 years (range: 46–60), and mean age of those in Group B was 68.6 years (range: 62–97). Group B patients had higher positive lymph nodes (43.2%), P=0.011. The frequency of extrathyroidal extension, multifocality, and lymphovascular space invasion was seen more in Group B than in Group A. Postsurgical complications (permanent hypoparathyroidism, bleeding, and wound infections) were also seen more in Group B (P=0.043, P=0.011, and P=0.021, respectively). Group B patients experienced more locoregional recurrences (11.0%, P=0.025); similarly, more distant metastases were observed in Group B (15.3%, P=0.003). The 10-year disease-free survival rates were 87.6% in Group A and 70.8% in Group B (P<0.0001). Conclusion: Differentiated thyroid cancer in patients aged above 60 years are more aggressive biologically and associated with a worse prognosis, and the morbidity is significantly high as compared to patients aged below 60 years. Keywords: differentiated thyroid cancers, patients aged above 45 years, aged above 60 years, clinicopathological characteristics, treatment outcomes, elderly patients, aged below 60 years, comparative analysisAL-Qahtani KHTunio MAAsiri MABayoumi YBalbaid AAljohani NJFatani HDove Medical PressarticleDifferentiated thyroid cancerspatients aged above 45 yearsaged above 60 yearsage below 60 yearsclinicopathological characteristicstreatment outcomeselderly patients. comparative analysisGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 1169-1174 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Differentiated thyroid cancers patients aged above 45 years aged above 60 years age below 60 years clinicopathological characteristics treatment outcomes elderly patients. comparative analysis Geriatrics RC952-954.6
spellingShingle	Differentiated thyroid cancers patients aged above 45 years aged above 60 years age below 60 years clinicopathological characteristics treatment outcomes elderly patients. comparative analysis Geriatrics RC952-954.6 AL-Qahtani KH Tunio MA Asiri MA Bayoumi Y Balbaid A Aljohani NJ Fatani H Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years
description	Khalid Hussain AL-Qahtani,1 Mutahir A Tunio,2 Mushabbab Al Asiri,2 Yasser Bayoumi,3 Ali Balbaid,2 Naji J Aljohani,4 Hanadi Fatani5 1Department of Otolaryngology-Head & Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2Department of Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, Saudi Arabia; 3Department of Radiation Oncology, NCI, Cairo University, Cairo, Egypt; 4Department of Endocrinology and Thyroid Oncology, 5Histopathology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, Saudi Arabia Introduction: The aim of this study was to evaluate the treatment outcomes of differentiated thyroid cancer in Saudi patients aged above 60 years. Materials and methods: Comparative analysis was performed in 252 patients aged 46–60 years (Group A) and 118 patients aged above 60 years (Group B), who had thyroidectomy, radioactive iodine-131, and thyroid-stimulating hormone suppression therapy between July 2000 and December 2012. Different clinicopathological features, treatment, complications, disease-free survival, and overall survival rates were compared. Results: Mean age of patients in Group A was 51.9 years (range: 46–60), and mean age of those in Group B was 68.6 years (range: 62–97). Group B patients had higher positive lymph nodes (43.2%), P=0.011. The frequency of extrathyroidal extension, multifocality, and lymphovascular space invasion was seen more in Group B than in Group A. Postsurgical complications (permanent hypoparathyroidism, bleeding, and wound infections) were also seen more in Group B (P=0.043, P=0.011, and P=0.021, respectively). Group B patients experienced more locoregional recurrences (11.0%, P=0.025); similarly, more distant metastases were observed in Group B (15.3%, P=0.003). The 10-year disease-free survival rates were 87.6% in Group A and 70.8% in Group B (P<0.0001). Conclusion: Differentiated thyroid cancer in patients aged above 60 years are more aggressive biologically and associated with a worse prognosis, and the morbidity is significantly high as compared to patients aged below 60 years. Keywords: differentiated thyroid cancers, patients aged above 45 years, aged above 60 years, clinicopathological characteristics, treatment outcomes, elderly patients, aged below 60 years, comparative analysis
format	article
author	AL-Qahtani KH Tunio MA Asiri MA Bayoumi Y Balbaid A Aljohani NJ Fatani H
author_facet	AL-Qahtani KH Tunio MA Asiri MA Bayoumi Y Balbaid A Aljohani NJ Fatani H
author_sort	AL-Qahtani KH
title	Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years
title_short	Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years
title_full	Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years
title_fullStr	Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years
title_full_unstemmed	Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years
title_sort	comparative clinicopathological and outcome analysis of differentiated thyroid cancer in saudi patients aged below 60 years and above 60 years
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/ff6fa28af47843d2b0fe0b45c897b11f
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Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years

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