Alzheimer’s Disease and Diabetes Mellitus in Comparison: The Therapeutic Efficacy of the Vanadium Compound

Alzheimer’s disease (AD) is an intractable neurodegenerative disease that leads to dementia, primarily in elderly people. The neurotoxicity of amyloid-beta (Aβ) and tau protein has been demonstrated over the last two decades. In line with these findings, several etiological hypotheses of AD have bee...

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Autores principales:	Zhijun He, Guanying You, Qiong Liu, Nan Li
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vanadium bis(ethylmaltolato)oxidovanadium (IV) (BEOV) diabetes mellitus Alzheimer’s disease peroxisome proliferator-activated receptor (PPARγ) Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ff715f596427464bb9e546beb632fb9a
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spelling	oai:doaj.org-article:ff715f596427464bb9e546beb632fb9a2021-11-11T17:21:08ZAlzheimer’s Disease and Diabetes Mellitus in Comparison: The Therapeutic Efficacy of the Vanadium Compound10.3390/ijms2221119311422-00671661-6596https://doaj.org/article/ff715f596427464bb9e546beb632fb9a2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11931https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Alzheimer’s disease (AD) is an intractable neurodegenerative disease that leads to dementia, primarily in elderly people. The neurotoxicity of amyloid-beta (Aβ) and tau protein has been demonstrated over the last two decades. In line with these findings, several etiological hypotheses of AD have been proposed, including the amyloid cascade hypothesis, the oxidative stress hypothesis, the inflammatory hypothesis, the cholinergic hypothesis, et al. In the meantime, great efforts had been made in developing effective drugs for AD. However, the clinical efficacy of the drugs that were approved by the US Food and Drug Association (FDA) to date were determined only mild/moderate. We recently adopted a vanadium compound bis(ethylmaltolato)-oxidovanadium (IV) (BEOV), which was originally used for curing diabetes mellitus (DM), to treat AD in a mouse model. It was shown that BEOV effectively reduced the Aβ level, ameliorated the inflammation in brains of the AD mice, and improved the spatial learning and memory activities of the AD mice. These finding encouraged us to further examine the mechanisms underlying the therapeutic effects of BEOV in AD. In this review, we summarized the achievement of vanadium compounds in medical studies and investigated the prospect of BEOV in AD and DM treatment.Zhijun HeGuanying YouQiong LiuNan LiMDPI AGarticlevanadiumbis(ethylmaltolato)oxidovanadium (IV) (BEOV)diabetes mellitus Alzheimer’s diseaseperoxisome proliferator-activated receptor (PPARγ)Biology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11931, p 11931 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vanadium bis(ethylmaltolato)oxidovanadium (IV) (BEOV) diabetes mellitus Alzheimer’s disease peroxisome proliferator-activated receptor (PPARγ) Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	vanadium bis(ethylmaltolato)oxidovanadium (IV) (BEOV) diabetes mellitus Alzheimer’s disease peroxisome proliferator-activated receptor (PPARγ) Biology (General) QH301-705.5 Chemistry QD1-999 Zhijun He Guanying You Qiong Liu Nan Li Alzheimer’s Disease and Diabetes Mellitus in Comparison: The Therapeutic Efficacy of the Vanadium Compound
description	Alzheimer’s disease (AD) is an intractable neurodegenerative disease that leads to dementia, primarily in elderly people. The neurotoxicity of amyloid-beta (Aβ) and tau protein has been demonstrated over the last two decades. In line with these findings, several etiological hypotheses of AD have been proposed, including the amyloid cascade hypothesis, the oxidative stress hypothesis, the inflammatory hypothesis, the cholinergic hypothesis, et al. In the meantime, great efforts had been made in developing effective drugs for AD. However, the clinical efficacy of the drugs that were approved by the US Food and Drug Association (FDA) to date were determined only mild/moderate. We recently adopted a vanadium compound bis(ethylmaltolato)-oxidovanadium (IV) (BEOV), which was originally used for curing diabetes mellitus (DM), to treat AD in a mouse model. It was shown that BEOV effectively reduced the Aβ level, ameliorated the inflammation in brains of the AD mice, and improved the spatial learning and memory activities of the AD mice. These finding encouraged us to further examine the mechanisms underlying the therapeutic effects of BEOV in AD. In this review, we summarized the achievement of vanadium compounds in medical studies and investigated the prospect of BEOV in AD and DM treatment.
format	article
author	Zhijun He Guanying You Qiong Liu Nan Li
author_facet	Zhijun He Guanying You Qiong Liu Nan Li
author_sort	Zhijun He
title	Alzheimer’s Disease and Diabetes Mellitus in Comparison: The Therapeutic Efficacy of the Vanadium Compound
title_short	Alzheimer’s Disease and Diabetes Mellitus in Comparison: The Therapeutic Efficacy of the Vanadium Compound
title_full	Alzheimer’s Disease and Diabetes Mellitus in Comparison: The Therapeutic Efficacy of the Vanadium Compound
title_fullStr	Alzheimer’s Disease and Diabetes Mellitus in Comparison: The Therapeutic Efficacy of the Vanadium Compound
title_full_unstemmed	Alzheimer’s Disease and Diabetes Mellitus in Comparison: The Therapeutic Efficacy of the Vanadium Compound
title_sort	alzheimer’s disease and diabetes mellitus in comparison: the therapeutic efficacy of the vanadium compound
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ff715f596427464bb9e546beb632fb9a
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Alzheimer’s Disease and Diabetes Mellitus in Comparison: The Therapeutic Efficacy of the Vanadium Compound

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