FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development

Epithelial-to-mesenchymal transition (EMT) regulates both processes of organism development and changes in cell state causing disease. Here, the authors show that an E3 ubiquitin ligase, FBXO32, regulates EMT via CtBP1 and the transcriptional program, and also mediates cancer metastatic burden and n...

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Autores principales:	Sanjeeb Kumar Sahu, Neha Tiwari, Abhijeet Pataskar, Yuan Zhuang, Marina Borisova, Mustafa Diken, Susanne Strand, Petra Beli, Vijay K. Tiwari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ff716e030bc54097b27f5ef7fddc1f22
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spelling	oai:doaj.org-article:ff716e030bc54097b27f5ef7fddc1f222021-12-02T15:38:56ZFBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development10.1038/s41467-017-01366-x2041-1723https://doaj.org/article/ff716e030bc54097b27f5ef7fddc1f222017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01366-xhttps://doaj.org/toc/2041-1723Epithelial-to-mesenchymal transition (EMT) regulates both processes of organism development and changes in cell state causing disease. Here, the authors show that an E3 ubiquitin ligase, FBXO32, regulates EMT via CtBP1 and the transcriptional program, and also mediates cancer metastatic burden and neurogenesis.Sanjeeb Kumar SahuNeha TiwariAbhijeet PataskarYuan ZhuangMarina BorisovaMustafa DikenSusanne StrandPetra BeliVijay K. TiwariNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sanjeeb Kumar Sahu Neha Tiwari Abhijeet Pataskar Yuan Zhuang Marina Borisova Mustafa Diken Susanne Strand Petra Beli Vijay K. Tiwari FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development
description	Epithelial-to-mesenchymal transition (EMT) regulates both processes of organism development and changes in cell state causing disease. Here, the authors show that an E3 ubiquitin ligase, FBXO32, regulates EMT via CtBP1 and the transcriptional program, and also mediates cancer metastatic burden and neurogenesis.
format	article
author	Sanjeeb Kumar Sahu Neha Tiwari Abhijeet Pataskar Yuan Zhuang Marina Borisova Mustafa Diken Susanne Strand Petra Beli Vijay K. Tiwari
author_facet	Sanjeeb Kumar Sahu Neha Tiwari Abhijeet Pataskar Yuan Zhuang Marina Borisova Mustafa Diken Susanne Strand Petra Beli Vijay K. Tiwari
author_sort	Sanjeeb Kumar Sahu
title	FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development
title_short	FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development
title_full	FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development
title_fullStr	FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development
title_full_unstemmed	FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development
title_sort	fbxo32 promotes microenvironment underlying epithelial-mesenchymal transition via ctbp1 during tumour metastasis and brain development
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ff716e030bc54097b27f5ef7fddc1f22
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FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development

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