Whole-Genome Sequencing to Identify Missed Rifampicin and Isoniazid Resistance Among Tuberculosis Isolates—Chennai, India, 2013–2016

Whole-Genome Sequencing to Identify Missed Rifampicin and Isoniazid Resistance Among Tuberculosis Isolates—Chennai, India, 2013–2016

India has a high burden of drug-resistant tuberculosis (DR TB) and many cases go undetected by current drug susceptibility tests (DSTs). This study was conducted to identify rifampicin (RIF) and isoniazid (INH) resistance associated genetic mutations undetected by current clinical diagnostics amongs...

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Autores principales: Sembulingam Tamilzhalagan, Sivakumar Shanmugam, Ashok Selvaraj, Sakthi Suba, Chittibabu Suganthi, Patrick K. Moonan, Diya Surie, Mukesh Kumar Sathyanarayanan, Narayanan Shivaram Gomathi, Lavanya Jayabal, Kuldeep Singh Sachdeva, Sriram Selvaraju, Soumya Swaminathan, Srikanth Prasad Tripathy, Patricia J. Hall, Uma Devi Ranganathan
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
drug susceptibility testing
genetic mutations
line probe assay
whole genome sequencing
DR TB
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/ff71cca09e6948818bf864696a9fed21
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