Decreasing glioma recurrence through adjuvant cancer stem cell inhibition
Josh Neman, Rahul JandialDivision of Neurosurgery, City of Hope National Cancer Center, Duarte, CA, USAAbstract: Gliomas remain one of the most challenging solid organ tumors to treat and are marked clinically by invariable recurrence despite multimodal intervention (surgery, chemotherapy, radiation...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2010
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| Acceso en línea: | https://doaj.org/article/ff725080636c46bf8b798680ec23244e |
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| Sumario: | Josh Neman, Rahul JandialDivision of Neurosurgery, City of Hope National Cancer Center, Duarte, CA, USAAbstract: Gliomas remain one of the most challenging solid organ tumors to treat and are marked clinically by invariable recurrence despite multimodal intervention (surgery, chemotherapy, radiation). This recurrence perhaps, is as a consequence of the failure to eradicate a tumor cell subpopulation, termed cancer stem cells. Isolating, characterizing, and understanding these tumor-initiating cells through cellular and molecular markers, along with genetic and epigenetic understanding will allow for selective targeting through therapeutic agents and holds promise for decreasing glioma recurrence.Keywords: glioma, cancer stem cells, epigenetic |
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