High-resolution linkage analyses to identify genes that influence Varroa sensitive hygiene behavior in honey bees.

Varroa mites (V. destructor) are a major threat to honey bees (Apis melilfera) and beekeeping worldwide and likely lead to colony decline if colonies are not treated. Most treatments involve chemical control of the mites; however, Varroa has evolved resistance to many of these miticides, leaving bee...

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Autores principales:	Jennifer M Tsuruda, Jeffrey W Harris, Lanie Bourgeois, Robert G Danka, Greg J Hunt
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ff72cf7856ae4f17a7357a90e33f1621
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spelling	oai:doaj.org-article:ff72cf7856ae4f17a7357a90e33f16212021-11-18T08:10:10ZHigh-resolution linkage analyses to identify genes that influence Varroa sensitive hygiene behavior in honey bees.1932-620310.1371/journal.pone.0048276https://doaj.org/article/ff72cf7856ae4f17a7357a90e33f16212012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23133626/?tool=EBIhttps://doaj.org/toc/1932-6203Varroa mites (V. destructor) are a major threat to honey bees (Apis melilfera) and beekeeping worldwide and likely lead to colony decline if colonies are not treated. Most treatments involve chemical control of the mites; however, Varroa has evolved resistance to many of these miticides, leaving beekeepers with a limited number of alternatives. A non-chemical control method is highly desirable for numerous reasons including lack of chemical residues and decreased likelihood of resistance. Varroa sensitive hygiene behavior is one of two behaviors identified that are most important for controlling the growth of Varroa populations in bee hives. To identify genes influencing this trait, a study was conducted to map quantitative trait loci (QTL). Individual workers of a backcross family were observed and evaluated for their VSH behavior in a mite-infested observation hive. Bees that uncapped or removed pupae were identified. The genotypes for 1,340 informative single nucleotide polymorphisms were used to construct a high-resolution genetic map and interval mapping was used to analyze the association of the genotypes with the performance of Varroa sensitive hygiene. We identified one major QTL on chromosome 9 (LOD score = 3.21) and a suggestive QTL on chromosome 1 (LOD = 1.95). The QTL confidence interval on chromosome 9 contains the gene 'no receptor potential A' and a dopamine receptor. 'No receptor potential A' is involved in vision and olfaction in Drosophila, and dopamine signaling has been previously shown to be required for aversive olfactory learning in honey bees, which is probably necessary for identifying mites within brood cells. Further studies on these candidate genes may allow for breeding bees with this trait using marker-assisted selection.Jennifer M TsurudaJeffrey W HarrisLanie BourgeoisRobert G DankaGreg J HuntPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e48276 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jennifer M Tsuruda Jeffrey W Harris Lanie Bourgeois Robert G Danka Greg J Hunt High-resolution linkage analyses to identify genes that influence Varroa sensitive hygiene behavior in honey bees.
description	Varroa mites (V. destructor) are a major threat to honey bees (Apis melilfera) and beekeeping worldwide and likely lead to colony decline if colonies are not treated. Most treatments involve chemical control of the mites; however, Varroa has evolved resistance to many of these miticides, leaving beekeepers with a limited number of alternatives. A non-chemical control method is highly desirable for numerous reasons including lack of chemical residues and decreased likelihood of resistance. Varroa sensitive hygiene behavior is one of two behaviors identified that are most important for controlling the growth of Varroa populations in bee hives. To identify genes influencing this trait, a study was conducted to map quantitative trait loci (QTL). Individual workers of a backcross family were observed and evaluated for their VSH behavior in a mite-infested observation hive. Bees that uncapped or removed pupae were identified. The genotypes for 1,340 informative single nucleotide polymorphisms were used to construct a high-resolution genetic map and interval mapping was used to analyze the association of the genotypes with the performance of Varroa sensitive hygiene. We identified one major QTL on chromosome 9 (LOD score = 3.21) and a suggestive QTL on chromosome 1 (LOD = 1.95). The QTL confidence interval on chromosome 9 contains the gene 'no receptor potential A' and a dopamine receptor. 'No receptor potential A' is involved in vision and olfaction in Drosophila, and dopamine signaling has been previously shown to be required for aversive olfactory learning in honey bees, which is probably necessary for identifying mites within brood cells. Further studies on these candidate genes may allow for breeding bees with this trait using marker-assisted selection.
format	article
author	Jennifer M Tsuruda Jeffrey W Harris Lanie Bourgeois Robert G Danka Greg J Hunt
author_facet	Jennifer M Tsuruda Jeffrey W Harris Lanie Bourgeois Robert G Danka Greg J Hunt
author_sort	Jennifer M Tsuruda
title	High-resolution linkage analyses to identify genes that influence Varroa sensitive hygiene behavior in honey bees.
title_short	High-resolution linkage analyses to identify genes that influence Varroa sensitive hygiene behavior in honey bees.
title_full	High-resolution linkage analyses to identify genes that influence Varroa sensitive hygiene behavior in honey bees.
title_fullStr	High-resolution linkage analyses to identify genes that influence Varroa sensitive hygiene behavior in honey bees.
title_full_unstemmed	High-resolution linkage analyses to identify genes that influence Varroa sensitive hygiene behavior in honey bees.
title_sort	high-resolution linkage analyses to identify genes that influence varroa sensitive hygiene behavior in honey bees.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/ff72cf7856ae4f17a7357a90e33f1621
work_keys_str_mv	AT jennifermtsuruda highresolutionlinkageanalysestoidentifygenesthatinfluencevarroasensitivehygienebehaviorinhoneybees AT jeffreywharris highresolutionlinkageanalysestoidentifygenesthatinfluencevarroasensitivehygienebehaviorinhoneybees AT laniebourgeois highresolutionlinkageanalysestoidentifygenesthatinfluencevarroasensitivehygienebehaviorinhoneybees AT robertgdanka highresolutionlinkageanalysestoidentifygenesthatinfluencevarroasensitivehygienebehaviorinhoneybees AT gregjhunt highresolutionlinkageanalysestoidentifygenesthatinfluencevarroasensitivehygienebehaviorinhoneybees
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High-resolution linkage analyses to identify genes that influence Varroa sensitive hygiene behavior in honey bees.

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