Characterization and Pathogenic Speculation of Xerostomia Associated with COVID-19: A Narrative Review

Patients with coronavirus disease 2019 (COVID-19) have become known to present with different oral symptoms. However, xerostomia remains poorly recognized compared with taste dysfunction. For better understanding of COVID-19 symptomatology, xerostomia associated withCOVID-19 was characterized and it...

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Autor principal:	Hironori Tsuchiya
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 xerostomia dry mouth hyposalivation prevalent persistent Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/ff7ddc7561ed4798a1c0df71b8469528
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spelling	oai:doaj.org-article:ff7ddc7561ed4798a1c0df71b84695282021-11-25T17:19:58ZCharacterization and Pathogenic Speculation of Xerostomia Associated with COVID-19: A Narrative Review10.3390/dj91101302304-6767https://doaj.org/article/ff7ddc7561ed4798a1c0df71b84695282021-11-01T00:00:00Zhttps://www.mdpi.com/2304-6767/9/11/130https://doaj.org/toc/2304-6767Patients with coronavirus disease 2019 (COVID-19) have become known to present with different oral symptoms. However, xerostomia remains poorly recognized compared with taste dysfunction. For better understanding of COVID-19 symptomatology, xerostomia associated withCOVID-19 was characterized and its possible pathogenesis was speculated by a narrative literature review. Scientific articles were retrieved by searching PubMed, LitCovid, ProQuest, Google Scholar, medRxiv and bioRxiv from 1 April 2020 with a cutoff date of 30 September 2021. Results of the literature search indicated that xerostomia is one of prevalent and persistent oral symptoms associated with COVID-19. In contrast to taste dysfunction, the prevalence and persistence of xerostomia do not necessarily depend on ethnicity, age, gender and disease severity of patients. COVID-19 xerostomia is pathogenically related to viral cellular entry-relevant protein expression, renin-angiotensin system disturbance, salivary gland inflammation, zinc deficiency, cranial neuropathy, intercurrent taste dysfunction, comorbidities and medications. Despite a close association with COVID-19, xerostomia, dry mouth and hyposalivation tend to be overlooked unlike ageusia, dysgeusia and hypogeusia. Although mouth dryness per se is not life-threating, it has an impact on the oral health-related quality of life. More attention should be paid to xerostomia in COVID-19 patients and survivors.Hironori TsuchiyaMDPI AGarticleCOVID-19xerostomiadry mouthhyposalivationprevalentpersistentDentistryRK1-715ENDentistry Journal, Vol 9, Iss 130, p 130 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 xerostomia dry mouth hyposalivation prevalent persistent Dentistry RK1-715
spellingShingle	COVID-19 xerostomia dry mouth hyposalivation prevalent persistent Dentistry RK1-715 Hironori Tsuchiya Characterization and Pathogenic Speculation of Xerostomia Associated with COVID-19: A Narrative Review
description	Patients with coronavirus disease 2019 (COVID-19) have become known to present with different oral symptoms. However, xerostomia remains poorly recognized compared with taste dysfunction. For better understanding of COVID-19 symptomatology, xerostomia associated withCOVID-19 was characterized and its possible pathogenesis was speculated by a narrative literature review. Scientific articles were retrieved by searching PubMed, LitCovid, ProQuest, Google Scholar, medRxiv and bioRxiv from 1 April 2020 with a cutoff date of 30 September 2021. Results of the literature search indicated that xerostomia is one of prevalent and persistent oral symptoms associated with COVID-19. In contrast to taste dysfunction, the prevalence and persistence of xerostomia do not necessarily depend on ethnicity, age, gender and disease severity of patients. COVID-19 xerostomia is pathogenically related to viral cellular entry-relevant protein expression, renin-angiotensin system disturbance, salivary gland inflammation, zinc deficiency, cranial neuropathy, intercurrent taste dysfunction, comorbidities and medications. Despite a close association with COVID-19, xerostomia, dry mouth and hyposalivation tend to be overlooked unlike ageusia, dysgeusia and hypogeusia. Although mouth dryness per se is not life-threating, it has an impact on the oral health-related quality of life. More attention should be paid to xerostomia in COVID-19 patients and survivors.
format	article
author	Hironori Tsuchiya
author_facet	Hironori Tsuchiya
author_sort	Hironori Tsuchiya
title	Characterization and Pathogenic Speculation of Xerostomia Associated with COVID-19: A Narrative Review
title_short	Characterization and Pathogenic Speculation of Xerostomia Associated with COVID-19: A Narrative Review
title_full	Characterization and Pathogenic Speculation of Xerostomia Associated with COVID-19: A Narrative Review
title_fullStr	Characterization and Pathogenic Speculation of Xerostomia Associated with COVID-19: A Narrative Review
title_full_unstemmed	Characterization and Pathogenic Speculation of Xerostomia Associated with COVID-19: A Narrative Review
title_sort	characterization and pathogenic speculation of xerostomia associated with covid-19: a narrative review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ff7ddc7561ed4798a1c0df71b8469528
work_keys_str_mv	AT hironoritsuchiya characterizationandpathogenicspeculationofxerostomiaassociatedwithcovid19anarrativereview
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Characterization and Pathogenic Speculation of Xerostomia Associated with COVID-19: A Narrative Review

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