In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets

Abstract MicroRNAs are small noncoding RNAs that have important roles in the lactation process and milk biosynthesis. Some polymorphisms have been studied in various livestock species from the perspective of pathology or production traits. To target variants that could be the causal variants of dair...

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Autores principales:	Céline Bourdon, Mekki Boussaha, Philippe Bardou, Marie-Pierre Sanchez, Sandrine Le Guillou, Thierry Tribout, Hélène Larroque, Didier Boichard, Rachel Rupp, Fabienne Le Provost, Gwenola Tosser-Klopp
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ff7f5d65df024c1c80a84448b4b38d4e
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spelling	oai:doaj.org-article:ff7f5d65df024c1c80a84448b4b38d4e2021-12-02T17:17:40ZIn silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets10.1038/s41598-021-98639-92045-2322https://doaj.org/article/ff7f5d65df024c1c80a84448b4b38d4e2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98639-9https://doaj.org/toc/2045-2322Abstract MicroRNAs are small noncoding RNAs that have important roles in the lactation process and milk biosynthesis. Some polymorphisms have been studied in various livestock species from the perspective of pathology or production traits. To target variants that could be the causal variants of dairy traits, genetic variants of microRNAs expressed in the mammary gland or present in milk and localized in dairy quantitative trait loci (QTLs) were investigated in bovine, caprine, and ovine species. In this study, a total of 59,124 (out of 28 millions), 13,427 (out of 87 millions), and 4761 (out of 38 millions) genetic variants in microRNAs expressed in the mammary gland or present in milk were identified in bovine, caprine, and ovine species, respectively. A total of 4679 of these detected bovine genetic variants are located in dairy QTLs. In caprine species, 127 genetic variants are localized in dairy QTLs. In ovine species, no genetic variant was identified in dairy QTLs. This study leads to the detection of microRNA genetic variants of interest in the context of dairy production, taking advantage of whole genome data to identify microRNA genetic variants expressed in the mammary gland and localized in dairy QTLs.Céline BourdonMekki BoussahaPhilippe BardouMarie-Pierre SanchezSandrine Le GuillouThierry TriboutHélène LarroqueDidier BoichardRachel RuppFabienne Le ProvostGwenola Tosser-KloppNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Céline Bourdon Mekki Boussaha Philippe Bardou Marie-Pierre Sanchez Sandrine Le Guillou Thierry Tribout Hélène Larroque Didier Boichard Rachel Rupp Fabienne Le Provost Gwenola Tosser-Klopp In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets
description	Abstract MicroRNAs are small noncoding RNAs that have important roles in the lactation process and milk biosynthesis. Some polymorphisms have been studied in various livestock species from the perspective of pathology or production traits. To target variants that could be the causal variants of dairy traits, genetic variants of microRNAs expressed in the mammary gland or present in milk and localized in dairy quantitative trait loci (QTLs) were investigated in bovine, caprine, and ovine species. In this study, a total of 59,124 (out of 28 millions), 13,427 (out of 87 millions), and 4761 (out of 38 millions) genetic variants in microRNAs expressed in the mammary gland or present in milk were identified in bovine, caprine, and ovine species, respectively. A total of 4679 of these detected bovine genetic variants are located in dairy QTLs. In caprine species, 127 genetic variants are localized in dairy QTLs. In ovine species, no genetic variant was identified in dairy QTLs. This study leads to the detection of microRNA genetic variants of interest in the context of dairy production, taking advantage of whole genome data to identify microRNA genetic variants expressed in the mammary gland and localized in dairy QTLs.
format	article
author	Céline Bourdon Mekki Boussaha Philippe Bardou Marie-Pierre Sanchez Sandrine Le Guillou Thierry Tribout Hélène Larroque Didier Boichard Rachel Rupp Fabienne Le Provost Gwenola Tosser-Klopp
author_facet	Céline Bourdon Mekki Boussaha Philippe Bardou Marie-Pierre Sanchez Sandrine Le Guillou Thierry Tribout Hélène Larroque Didier Boichard Rachel Rupp Fabienne Le Provost Gwenola Tosser-Klopp
author_sort	Céline Bourdon
title	In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets
title_short	In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets
title_full	In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets
title_fullStr	In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets
title_full_unstemmed	In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets
title_sort	in silico identification of variations in micrornas with a potential impact on dairy traits using whole ruminant genome snp datasets
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ff7f5d65df024c1c80a84448b4b38d4e
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In silico identification of variations in microRNAs with a potential impact on dairy traits using whole ruminant genome SNP datasets

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