d-Aspartate consumption selectively promotes intermediate-term spatial memory and the expression of hippocampal NMDA receptor subunits

Abstract d-Aspartate (d-Asp) and d-serine (d-Ser) have been proposed to promote early-phase LTP in vitro and to enhance spatial memory in vivo. Here, we investigated the behavioural effects of chronic consumption of d-Asp and d-Ser on spatial learning of mice together with the expression of NMDA rec...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gergely Zachar, Róbert Kemecsei, Szilvia Márta Papp, Katalin Wéber, Tamás Kisparti, Teadora Tyler, Gábor Gáspár, Tamás Balázsa, András Csillag
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ff839cb867ff477d947f5ef6aa356b43
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ff839cb867ff477d947f5ef6aa356b43
record_format	dspace
spelling	oai:doaj.org-article:ff839cb867ff477d947f5ef6aa356b432021-12-02T13:17:42Zd-Aspartate consumption selectively promotes intermediate-term spatial memory and the expression of hippocampal NMDA receptor subunits10.1038/s41598-021-85360-w2045-2322https://doaj.org/article/ff839cb867ff477d947f5ef6aa356b432021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85360-whttps://doaj.org/toc/2045-2322Abstract d-Aspartate (d-Asp) and d-serine (d-Ser) have been proposed to promote early-phase LTP in vitro and to enhance spatial memory in vivo. Here, we investigated the behavioural effects of chronic consumption of d-Asp and d-Ser on spatial learning of mice together with the expression of NMDA receptors. We also studied the alterations of neurogenesis by morphometric analysis of bromo-deoxyuridine incorporating and doublecortin expressing cells in the hippocampus. Our results specify a time period (3–4 h post-training), within which the animals exposed to d-Asp (but not d-Ser) show a more stable memory during retrieval. The cognitive improvement is due to elimination of transient bouts of destabilization and reconsolidation of memory, rather than to enhanced acquisition. d-Asp also protracted reversal learning probably due to reduced plasticity. Expression of GluN1 and GluN2A subunits was elevated in the hippocampus of d-Asp (but not d-Ser) treated mice. d-Asp or d-Ser did not alter the proliferation of neuronal progenitor cells in the hippocampus. The observed learning-related changes evoked by d-Asp are unlikely to be due to enhanced proliferation and recruitment of new neurones. Rather, they are likely associated with an upregulation of NMDA receptors, as well as a reorganization of receptor subunit assemblies in existing hippocampal/dentate neurons.Gergely ZacharRóbert KemecseiSzilvia Márta PappKatalin WéberTamás KispartiTeadora TylerGábor GáspárTamás BalázsaAndrás CsillagNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gergely Zachar Róbert Kemecsei Szilvia Márta Papp Katalin Wéber Tamás Kisparti Teadora Tyler Gábor Gáspár Tamás Balázsa András Csillag d-Aspartate consumption selectively promotes intermediate-term spatial memory and the expression of hippocampal NMDA receptor subunits
description	Abstract d-Aspartate (d-Asp) and d-serine (d-Ser) have been proposed to promote early-phase LTP in vitro and to enhance spatial memory in vivo. Here, we investigated the behavioural effects of chronic consumption of d-Asp and d-Ser on spatial learning of mice together with the expression of NMDA receptors. We also studied the alterations of neurogenesis by morphometric analysis of bromo-deoxyuridine incorporating and doublecortin expressing cells in the hippocampus. Our results specify a time period (3–4 h post-training), within which the animals exposed to d-Asp (but not d-Ser) show a more stable memory during retrieval. The cognitive improvement is due to elimination of transient bouts of destabilization and reconsolidation of memory, rather than to enhanced acquisition. d-Asp also protracted reversal learning probably due to reduced plasticity. Expression of GluN1 and GluN2A subunits was elevated in the hippocampus of d-Asp (but not d-Ser) treated mice. d-Asp or d-Ser did not alter the proliferation of neuronal progenitor cells in the hippocampus. The observed learning-related changes evoked by d-Asp are unlikely to be due to enhanced proliferation and recruitment of new neurones. Rather, they are likely associated with an upregulation of NMDA receptors, as well as a reorganization of receptor subunit assemblies in existing hippocampal/dentate neurons.
format	article
author	Gergely Zachar Róbert Kemecsei Szilvia Márta Papp Katalin Wéber Tamás Kisparti Teadora Tyler Gábor Gáspár Tamás Balázsa András Csillag
author_facet	Gergely Zachar Róbert Kemecsei Szilvia Márta Papp Katalin Wéber Tamás Kisparti Teadora Tyler Gábor Gáspár Tamás Balázsa András Csillag
author_sort	Gergely Zachar
title	d-Aspartate consumption selectively promotes intermediate-term spatial memory and the expression of hippocampal NMDA receptor subunits
title_short	d-Aspartate consumption selectively promotes intermediate-term spatial memory and the expression of hippocampal NMDA receptor subunits
title_full	d-Aspartate consumption selectively promotes intermediate-term spatial memory and the expression of hippocampal NMDA receptor subunits
title_fullStr	d-Aspartate consumption selectively promotes intermediate-term spatial memory and the expression of hippocampal NMDA receptor subunits
title_full_unstemmed	d-Aspartate consumption selectively promotes intermediate-term spatial memory and the expression of hippocampal NMDA receptor subunits
title_sort	d-aspartate consumption selectively promotes intermediate-term spatial memory and the expression of hippocampal nmda receptor subunits
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ff839cb867ff477d947f5ef6aa356b43
work_keys_str_mv	AT gergelyzachar daspartateconsumptionselectivelypromotesintermediatetermspatialmemoryandtheexpressionofhippocampalnmdareceptorsubunits AT robertkemecsei daspartateconsumptionselectivelypromotesintermediatetermspatialmemoryandtheexpressionofhippocampalnmdareceptorsubunits AT szilviamartapapp daspartateconsumptionselectivelypromotesintermediatetermspatialmemoryandtheexpressionofhippocampalnmdareceptorsubunits AT katalinweber daspartateconsumptionselectivelypromotesintermediatetermspatialmemoryandtheexpressionofhippocampalnmdareceptorsubunits AT tamaskisparti daspartateconsumptionselectivelypromotesintermediatetermspatialmemoryandtheexpressionofhippocampalnmdareceptorsubunits AT teadoratyler daspartateconsumptionselectivelypromotesintermediatetermspatialmemoryandtheexpressionofhippocampalnmdareceptorsubunits AT gaborgaspar daspartateconsumptionselectivelypromotesintermediatetermspatialmemoryandtheexpressionofhippocampalnmdareceptorsubunits AT tamasbalazsa daspartateconsumptionselectivelypromotesintermediatetermspatialmemoryandtheexpressionofhippocampalnmdareceptorsubunits AT andrascsillag daspartateconsumptionselectivelypromotesintermediatetermspatialmemoryandtheexpressionofhippocampalnmdareceptorsubunits
_version_	1718393368870912000

d-Aspartate consumption selectively promotes intermediate-term spatial memory and the expression of hippocampal NMDA receptor subunits

Ejemplares similares