Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase

Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase

The nature of the mitochondrial permeability transition pore (PTP) is still under debate. Here, through genetically modified F-ATP synthase, the authors show that PTP formation can be mediated by F-ATP synthase or by adenine nucleotide translocator, suggesting the existence of distinct but related p...

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Autores principales: Andrea Carrer, Ludovica Tommasin, Justina Šileikytė, Francesco Ciscato, Riccardo Filadi, Andrea Urbani, Michael Forte, Andrea Rasola, Ildikò Szabò, Michela Carraro, Paolo Bernardi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/ff86550a121a41e6be8159ac86257c13
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