Hematological Changes Following Low Dose Radiation Therapy and Comparison to Current Standard of Care Cancer Treatments

Cancer is the second leading cause of mortality worldwide accounting for almost 10 million deaths in 2020. Current standard of care treatment varies depending on the type and stage of disease, but commonly includes surgery, chemotherapy, and/or radiation therapy. There is evidence that whole- and ha...

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Autores principales:	Alexandra Jameus, Allison E. Kennedy, Christopher Thome
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ff8a5fce13ce400c83b20d0a2d44f999
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spelling	oai:doaj.org-article:ff8a5fce13ce400c83b20d0a2d44f9992021-11-16T23:33:22ZHematological Changes Following Low Dose Radiation Therapy and Comparison to Current Standard of Care Cancer Treatments1559-325810.1177/15593258211056196https://doaj.org/article/ff8a5fce13ce400c83b20d0a2d44f9992021-11-01T00:00:00Zhttps://doi.org/10.1177/15593258211056196https://doaj.org/toc/1559-3258Cancer is the second leading cause of mortality worldwide accounting for almost 10 million deaths in 2020. Current standard of care treatment varies depending on the type and stage of disease, but commonly includes surgery, chemotherapy, and/or radiation therapy. There is evidence that whole- and half-body exposure to low dose ionizing radiation can also be an effective therapeutic due to its stimulation of anti-cancer immunity. One of the limiting factors for past clinical trials using low dose radiation therapy has been adverse hematological events. However, similar hematological changes are also frequently reported following standard of care treatments in oncology. This review summarizes the effects of various cancer therapies on hematologic toxicity through the evaluation of complete blood count reports. The reviewed literature elucidates hematological trends in patients undergoing chemotherapy, and both high and low dose radiation therapy. In general, high dose radiation and chemotherapy can result in widespread changes in blood counts, with the most severe effects related to leukopenia. Overall, compared to standard of care treatments, low dose radiation results in similar, yet more mild hematological changes. Taken together, hematological toxicities should not be a limiting factor in the applicability of low dose radiation as a cancer therapeutic.Alexandra JameusAllison E. KennedyChristopher ThomeSAGE PublishingarticleTherapeutics. PharmacologyRM1-950ENDose-Response, Vol 19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950
spellingShingle	Therapeutics. Pharmacology RM1-950 Alexandra Jameus Allison E. Kennedy Christopher Thome Hematological Changes Following Low Dose Radiation Therapy and Comparison to Current Standard of Care Cancer Treatments
description	Cancer is the second leading cause of mortality worldwide accounting for almost 10 million deaths in 2020. Current standard of care treatment varies depending on the type and stage of disease, but commonly includes surgery, chemotherapy, and/or radiation therapy. There is evidence that whole- and half-body exposure to low dose ionizing radiation can also be an effective therapeutic due to its stimulation of anti-cancer immunity. One of the limiting factors for past clinical trials using low dose radiation therapy has been adverse hematological events. However, similar hematological changes are also frequently reported following standard of care treatments in oncology. This review summarizes the effects of various cancer therapies on hematologic toxicity through the evaluation of complete blood count reports. The reviewed literature elucidates hematological trends in patients undergoing chemotherapy, and both high and low dose radiation therapy. In general, high dose radiation and chemotherapy can result in widespread changes in blood counts, with the most severe effects related to leukopenia. Overall, compared to standard of care treatments, low dose radiation results in similar, yet more mild hematological changes. Taken together, hematological toxicities should not be a limiting factor in the applicability of low dose radiation as a cancer therapeutic.
format	article
author	Alexandra Jameus Allison E. Kennedy Christopher Thome
author_facet	Alexandra Jameus Allison E. Kennedy Christopher Thome
author_sort	Alexandra Jameus
title	Hematological Changes Following Low Dose Radiation Therapy and Comparison to Current Standard of Care Cancer Treatments
title_short	Hematological Changes Following Low Dose Radiation Therapy and Comparison to Current Standard of Care Cancer Treatments
title_full	Hematological Changes Following Low Dose Radiation Therapy and Comparison to Current Standard of Care Cancer Treatments
title_fullStr	Hematological Changes Following Low Dose Radiation Therapy and Comparison to Current Standard of Care Cancer Treatments
title_full_unstemmed	Hematological Changes Following Low Dose Radiation Therapy and Comparison to Current Standard of Care Cancer Treatments
title_sort	hematological changes following low dose radiation therapy and comparison to current standard of care cancer treatments
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/ff8a5fce13ce400c83b20d0a2d44f999
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Hematological Changes Following Low Dose Radiation Therapy and Comparison to Current Standard of Care Cancer Treatments

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