Platelet distribution width correlates with prognosis of non-small cell lung cancer

Abstract Platelets play a multifaceted role in cancer progression and metastasis. Mean platelet volume (MPV) and platelet distribution width (PDW) are commonly used platelet parameters from routine blood test. The aim of the present study was to investigate the correlation between platelet indices a...

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Main Authors:	Ming-ming Cui, Na Li, Xing Liu, Zhi-yuan Yun, Ye Niu, Yong Zhang, Boning Gao, Tiemin Liu, Rui-tao Wang
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Medicine R Science Q
Online Access:	https://doaj.org/article/ff8fdd5d331f4b2dae39d2fe78bb8047
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spelling	oai:doaj.org-article:ff8fdd5d331f4b2dae39d2fe78bb80472021-12-02T11:52:16ZPlatelet distribution width correlates with prognosis of non-small cell lung cancer10.1038/s41598-017-03772-z2045-2322https://doaj.org/article/ff8fdd5d331f4b2dae39d2fe78bb80472017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03772-zhttps://doaj.org/toc/2045-2322Abstract Platelets play a multifaceted role in cancer progression and metastasis. Mean platelet volume (MPV) and platelet distribution width (PDW) are commonly used platelet parameters from routine blood test. The aim of the present study was to investigate the correlation between platelet indices and prognosis in patients with non-small cell lung cancer (NSCLC). A total of 270 patients who were diagnosed with NSCLC between January 2009 and December 2009 were retrospectively analyzed. Patients’ characteristics and hematologic tests data at initial diagnosis were collected. The overall survival rate was estimated using Kaplan-Meier method. The prognostic analysis was carried out with univariate and multivariate Cox regressions model. Reduced PDW was significantly correlated with T stage, N stage, TNM stage, and histological type of the disease. Moreover, survival analysis showed that the overall survival of patients with PDW ≥ 16.3% was significantly longer than that of those with PDW < 16.3% (P < 0.001). In multivariate Cox regression model, age, sex, TNM stage, and PDW were identified as independent prognostic factors for overall survival (for PDW, P < 0.001). In conclusion, reduced PDW is an unfavorable predictive factor of NSCLC patient survival. Further studies are warranted.Ming-ming CuiNa LiXing LiuZhi-yuan YunYe NiuYong ZhangBoning GaoTiemin LiuRui-tao WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ming-ming Cui Na Li Xing Liu Zhi-yuan Yun Ye Niu Yong Zhang Boning Gao Tiemin Liu Rui-tao Wang Platelet distribution width correlates with prognosis of non-small cell lung cancer
description	Abstract Platelets play a multifaceted role in cancer progression and metastasis. Mean platelet volume (MPV) and platelet distribution width (PDW) are commonly used platelet parameters from routine blood test. The aim of the present study was to investigate the correlation between platelet indices and prognosis in patients with non-small cell lung cancer (NSCLC). A total of 270 patients who were diagnosed with NSCLC between January 2009 and December 2009 were retrospectively analyzed. Patients’ characteristics and hematologic tests data at initial diagnosis were collected. The overall survival rate was estimated using Kaplan-Meier method. The prognostic analysis was carried out with univariate and multivariate Cox regressions model. Reduced PDW was significantly correlated with T stage, N stage, TNM stage, and histological type of the disease. Moreover, survival analysis showed that the overall survival of patients with PDW ≥ 16.3% was significantly longer than that of those with PDW < 16.3% (P < 0.001). In multivariate Cox regression model, age, sex, TNM stage, and PDW were identified as independent prognostic factors for overall survival (for PDW, P < 0.001). In conclusion, reduced PDW is an unfavorable predictive factor of NSCLC patient survival. Further studies are warranted.
format	article
author	Ming-ming Cui Na Li Xing Liu Zhi-yuan Yun Ye Niu Yong Zhang Boning Gao Tiemin Liu Rui-tao Wang
author_facet	Ming-ming Cui Na Li Xing Liu Zhi-yuan Yun Ye Niu Yong Zhang Boning Gao Tiemin Liu Rui-tao Wang
author_sort	Ming-ming Cui
title	Platelet distribution width correlates with prognosis of non-small cell lung cancer
title_short	Platelet distribution width correlates with prognosis of non-small cell lung cancer
title_full	Platelet distribution width correlates with prognosis of non-small cell lung cancer
title_fullStr	Platelet distribution width correlates with prognosis of non-small cell lung cancer
title_full_unstemmed	Platelet distribution width correlates with prognosis of non-small cell lung cancer
title_sort	platelet distribution width correlates with prognosis of non-small cell lung cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ff8fdd5d331f4b2dae39d2fe78bb8047
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Platelet distribution width correlates with prognosis of non-small cell lung cancer

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