Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2016
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/ff910db139f74f1fb230ff9dacdc3391 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:ff910db139f74f1fb230ff9dacdc3391 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:ff910db139f74f1fb230ff9dacdc33912021-12-02T15:35:46ZFemale chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome10.1038/ncomms118432041-1723https://doaj.org/article/ff910db139f74f1fb230ff9dacdc33912016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11843https://doaj.org/toc/2041-1723It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer riskMitchell J. MachielaWeiyin ZhouEric KarlinsJoshua N. SampsonNeal D. FreedmanQi YangBelynda HicksCasey DagnallChristopher HautmanKevin B. JacobsChristian C. AbnetMelinda C. AldrichChristopher AmosLaufey T. AmundadottirAlan A. ArslanLaura E. Beane-FreemanSonja I. BerndtAmanda BlackWilliam J. BlotCathryn H. BockPaige M. BracciLouise A. BrintonH Bas Bueno-de-MesquitaLaurie BurdettJulie E. BuringMary A. ButlerFederico CanzianTania CarreónKari G. ChaffeeI-Shou ChangNilanjan ChatterjeeChu ChenConstance ChenKexin ChenCharles C. ChungLinda S. CookMarta Crous BouMichael CullenFaith G. DavisImmaculata De VivoTi DingJennifer DohertyEric J. DuellCaroline G. EpsteinJin-Hu FanJonine D. FigueroaJoseph F. FraumeniChristine M. FriedenreichCharles S. FuchsSteven GallingerYu-Tang GaoSusan M. GapsturMontserrat Garcia-ClosasMia M. GaudetJ. Michael GazianoGraham G. GilesElizabeth M. GillandersEdward L. GiovannucciLynn GoldinAlisa M. GoldsteinChristopher A. HaimanGoran HallmansSusan E. HankinsonCurtis C. HarrisRoger HenrikssonElizabeth A. HollyYun-Chul HongRobert N. HooverChao A. HsiungNan HuWei HuDavid J. HunterAmy HutchinsonMazda JenabChristoffer JohansenKay-Tee KhawHee Nam KimYeul Hong KimYoung Tae KimAlison P. KleinRobert KleinWoon-Puay KohLaurence N. KolonelCharles KooperbergPeter KraftVittorio KroghRobert C. KurtzAndrea LaCroixQing LanMaria Teresa LandiLoic Le MarchandDonghui LiXiaolin LiangLinda M. LiaoDongxin LinJianjun LiuJolanta LissowskaLingeng LuAnthony M. MaglioccoNuria MalatsKeitaro MatsuoLorna H. McNeillRobert R. McWilliamsBeatrice S. MelinLisa MirabelloLee MooreSara H. OlsonIrene OrlowJae Yong ParkAna Patiño-GarciaBeata PeplonskaUlrike PetersGloria M. PetersenLoreall PoolerJennifer PrescottLudmila Prokunina-OlssonMark P. PurdueYou-Lin QiaoPreetha RajaramanFrancisco X. RealElio RiboliHarvey A. RischBenjamin Rodriguez-SantiagoAvima M. RuderSharon A. SavageFredrick SchumacherAnn G. SchwartzKendra L. SchwartzAdeline SeowVeronica Wendy SetiawanGianluca SeveriHongbing ShenXin ShengMin-Ho ShinXiao-Ou ShuDebra T. SilvermanMargaret R. SpitzVictoria L. StevensRachael Stolzenberg-SolomonDaniel StramZe-Zhong TangPhilip R. TaylorLauren R. TerasGeoffrey S. TobiasDavid Van Den BergKala VisvanathanSholom WacholderJiu-Cun WangZhaoming WangNicolas WentzensenWilliam WheelerEmily WhiteJohn K. WienckeBrian M. WolpinMaria Pik WongChen WuTangchun WuXifeng WuYi-Long WuJay S. WunderLucy XiaHannah P. YangPan-Chyr YangKai YuKrista A. ZanettiAnne Zeleniuch-JacquotteWei ZhengBaosen ZhouRegina G. ZieglerLuis A. Perez-JuradoNeil E. CaporasoNathaniel RothmanMargaret TuckerMichael C. DeanMeredith YeagerStephen J. ChanockNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Mitchell J. Machiela Weiyin Zhou Eric Karlins Joshua N. Sampson Neal D. Freedman Qi Yang Belynda Hicks Casey Dagnall Christopher Hautman Kevin B. Jacobs Christian C. Abnet Melinda C. Aldrich Christopher Amos Laufey T. Amundadottir Alan A. Arslan Laura E. Beane-Freeman Sonja I. Berndt Amanda Black William J. Blot Cathryn H. Bock Paige M. Bracci Louise A. Brinton H Bas Bueno-de-Mesquita Laurie Burdett Julie E. Buring Mary A. Butler Federico Canzian Tania Carreón Kari G. Chaffee I-Shou Chang Nilanjan Chatterjee Chu Chen Constance Chen Kexin Chen Charles C. Chung Linda S. Cook Marta Crous Bou Michael Cullen Faith G. Davis Immaculata De Vivo Ti Ding Jennifer Doherty Eric J. Duell Caroline G. Epstein Jin-Hu Fan Jonine D. Figueroa Joseph F. Fraumeni Christine M. Friedenreich Charles S. Fuchs Steven Gallinger Yu-Tang Gao Susan M. Gapstur Montserrat Garcia-Closas Mia M. Gaudet J. Michael Gaziano Graham G. Giles Elizabeth M. Gillanders Edward L. Giovannucci Lynn Goldin Alisa M. Goldstein Christopher A. Haiman Goran Hallmans Susan E. Hankinson Curtis C. Harris Roger Henriksson Elizabeth A. Holly Yun-Chul Hong Robert N. Hoover Chao A. Hsiung Nan Hu Wei Hu David J. Hunter Amy Hutchinson Mazda Jenab Christoffer Johansen Kay-Tee Khaw Hee Nam Kim Yeul Hong Kim Young Tae Kim Alison P. Klein Robert Klein Woon-Puay Koh Laurence N. Kolonel Charles Kooperberg Peter Kraft Vittorio Krogh Robert C. Kurtz Andrea LaCroix Qing Lan Maria Teresa Landi Loic Le Marchand Donghui Li Xiaolin Liang Linda M. Liao Dongxin Lin Jianjun Liu Jolanta Lissowska Lingeng Lu Anthony M. Magliocco Nuria Malats Keitaro Matsuo Lorna H. McNeill Robert R. McWilliams Beatrice S. Melin Lisa Mirabello Lee Moore Sara H. Olson Irene Orlow Jae Yong Park Ana Patiño-Garcia Beata Peplonska Ulrike Peters Gloria M. Petersen Loreall Pooler Jennifer Prescott Ludmila Prokunina-Olsson Mark P. Purdue You-Lin Qiao Preetha Rajaraman Francisco X. Real Elio Riboli Harvey A. Risch Benjamin Rodriguez-Santiago Avima M. Ruder Sharon A. Savage Fredrick Schumacher Ann G. Schwartz Kendra L. Schwartz Adeline Seow Veronica Wendy Setiawan Gianluca Severi Hongbing Shen Xin Sheng Min-Ho Shin Xiao-Ou Shu Debra T. Silverman Margaret R. Spitz Victoria L. Stevens Rachael Stolzenberg-Solomon Daniel Stram Ze-Zhong Tang Philip R. Taylor Lauren R. Teras Geoffrey S. Tobias David Van Den Berg Kala Visvanathan Sholom Wacholder Jiu-Cun Wang Zhaoming Wang Nicolas Wentzensen William Wheeler Emily White John K. Wiencke Brian M. Wolpin Maria Pik Wong Chen Wu Tangchun Wu Xifeng Wu Yi-Long Wu Jay S. Wunder Lucy Xia Hannah P. Yang Pan-Chyr Yang Kai Yu Krista A. Zanetti Anne Zeleniuch-Jacquotte Wei Zheng Baosen Zhou Regina G. Ziegler Luis A. Perez-Jurado Neil E. Caporaso Nathaniel Rothman Margaret Tucker Michael C. Dean Meredith Yeager Stephen J. Chanock Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome |
| description |
It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer risk |
| format |
article |
| author |
Mitchell J. Machiela Weiyin Zhou Eric Karlins Joshua N. Sampson Neal D. Freedman Qi Yang Belynda Hicks Casey Dagnall Christopher Hautman Kevin B. Jacobs Christian C. Abnet Melinda C. Aldrich Christopher Amos Laufey T. Amundadottir Alan A. Arslan Laura E. Beane-Freeman Sonja I. Berndt Amanda Black William J. Blot Cathryn H. Bock Paige M. Bracci Louise A. Brinton H Bas Bueno-de-Mesquita Laurie Burdett Julie E. Buring Mary A. Butler Federico Canzian Tania Carreón Kari G. Chaffee I-Shou Chang Nilanjan Chatterjee Chu Chen Constance Chen Kexin Chen Charles C. Chung Linda S. Cook Marta Crous Bou Michael Cullen Faith G. Davis Immaculata De Vivo Ti Ding Jennifer Doherty Eric J. Duell Caroline G. Epstein Jin-Hu Fan Jonine D. Figueroa Joseph F. Fraumeni Christine M. Friedenreich Charles S. Fuchs Steven Gallinger Yu-Tang Gao Susan M. Gapstur Montserrat Garcia-Closas Mia M. Gaudet J. Michael Gaziano Graham G. Giles Elizabeth M. Gillanders Edward L. Giovannucci Lynn Goldin Alisa M. Goldstein Christopher A. Haiman Goran Hallmans Susan E. Hankinson Curtis C. Harris Roger Henriksson Elizabeth A. Holly Yun-Chul Hong Robert N. Hoover Chao A. Hsiung Nan Hu Wei Hu David J. Hunter Amy Hutchinson Mazda Jenab Christoffer Johansen Kay-Tee Khaw Hee Nam Kim Yeul Hong Kim Young Tae Kim Alison P. Klein Robert Klein Woon-Puay Koh Laurence N. Kolonel Charles Kooperberg Peter Kraft Vittorio Krogh Robert C. Kurtz Andrea LaCroix Qing Lan Maria Teresa Landi Loic Le Marchand Donghui Li Xiaolin Liang Linda M. Liao Dongxin Lin Jianjun Liu Jolanta Lissowska Lingeng Lu Anthony M. Magliocco Nuria Malats Keitaro Matsuo Lorna H. McNeill Robert R. McWilliams Beatrice S. Melin Lisa Mirabello Lee Moore Sara H. Olson Irene Orlow Jae Yong Park Ana Patiño-Garcia Beata Peplonska Ulrike Peters Gloria M. Petersen Loreall Pooler Jennifer Prescott Ludmila Prokunina-Olsson Mark P. Purdue You-Lin Qiao Preetha Rajaraman Francisco X. Real Elio Riboli Harvey A. Risch Benjamin Rodriguez-Santiago Avima M. Ruder Sharon A. Savage Fredrick Schumacher Ann G. Schwartz Kendra L. Schwartz Adeline Seow Veronica Wendy Setiawan Gianluca Severi Hongbing Shen Xin Sheng Min-Ho Shin Xiao-Ou Shu Debra T. Silverman Margaret R. Spitz Victoria L. Stevens Rachael Stolzenberg-Solomon Daniel Stram Ze-Zhong Tang Philip R. Taylor Lauren R. Teras Geoffrey S. Tobias David Van Den Berg Kala Visvanathan Sholom Wacholder Jiu-Cun Wang Zhaoming Wang Nicolas Wentzensen William Wheeler Emily White John K. Wiencke Brian M. Wolpin Maria Pik Wong Chen Wu Tangchun Wu Xifeng Wu Yi-Long Wu Jay S. Wunder Lucy Xia Hannah P. Yang Pan-Chyr Yang Kai Yu Krista A. Zanetti Anne Zeleniuch-Jacquotte Wei Zheng Baosen Zhou Regina G. Ziegler Luis A. Perez-Jurado Neil E. Caporaso Nathaniel Rothman Margaret Tucker Michael C. Dean Meredith Yeager Stephen J. Chanock |
| author_facet |
Mitchell J. Machiela Weiyin Zhou Eric Karlins Joshua N. Sampson Neal D. Freedman Qi Yang Belynda Hicks Casey Dagnall Christopher Hautman Kevin B. Jacobs Christian C. Abnet Melinda C. Aldrich Christopher Amos Laufey T. Amundadottir Alan A. Arslan Laura E. Beane-Freeman Sonja I. Berndt Amanda Black William J. Blot Cathryn H. Bock Paige M. Bracci Louise A. Brinton H Bas Bueno-de-Mesquita Laurie Burdett Julie E. Buring Mary A. Butler Federico Canzian Tania Carreón Kari G. Chaffee I-Shou Chang Nilanjan Chatterjee Chu Chen Constance Chen Kexin Chen Charles C. Chung Linda S. Cook Marta Crous Bou Michael Cullen Faith G. Davis Immaculata De Vivo Ti Ding Jennifer Doherty Eric J. Duell Caroline G. Epstein Jin-Hu Fan Jonine D. Figueroa Joseph F. Fraumeni Christine M. Friedenreich Charles S. Fuchs Steven Gallinger Yu-Tang Gao Susan M. Gapstur Montserrat Garcia-Closas Mia M. Gaudet J. Michael Gaziano Graham G. Giles Elizabeth M. Gillanders Edward L. Giovannucci Lynn Goldin Alisa M. Goldstein Christopher A. Haiman Goran Hallmans Susan E. Hankinson Curtis C. Harris Roger Henriksson Elizabeth A. Holly Yun-Chul Hong Robert N. Hoover Chao A. Hsiung Nan Hu Wei Hu David J. Hunter Amy Hutchinson Mazda Jenab Christoffer Johansen Kay-Tee Khaw Hee Nam Kim Yeul Hong Kim Young Tae Kim Alison P. Klein Robert Klein Woon-Puay Koh Laurence N. Kolonel Charles Kooperberg Peter Kraft Vittorio Krogh Robert C. Kurtz Andrea LaCroix Qing Lan Maria Teresa Landi Loic Le Marchand Donghui Li Xiaolin Liang Linda M. Liao Dongxin Lin Jianjun Liu Jolanta Lissowska Lingeng Lu Anthony M. Magliocco Nuria Malats Keitaro Matsuo Lorna H. McNeill Robert R. McWilliams Beatrice S. Melin Lisa Mirabello Lee Moore Sara H. Olson Irene Orlow Jae Yong Park Ana Patiño-Garcia Beata Peplonska Ulrike Peters Gloria M. Petersen Loreall Pooler Jennifer Prescott Ludmila Prokunina-Olsson Mark P. Purdue You-Lin Qiao Preetha Rajaraman Francisco X. Real Elio Riboli Harvey A. Risch Benjamin Rodriguez-Santiago Avima M. Ruder Sharon A. Savage Fredrick Schumacher Ann G. Schwartz Kendra L. Schwartz Adeline Seow Veronica Wendy Setiawan Gianluca Severi Hongbing Shen Xin Sheng Min-Ho Shin Xiao-Ou Shu Debra T. Silverman Margaret R. Spitz Victoria L. Stevens Rachael Stolzenberg-Solomon Daniel Stram Ze-Zhong Tang Philip R. Taylor Lauren R. Teras Geoffrey S. Tobias David Van Den Berg Kala Visvanathan Sholom Wacholder Jiu-Cun Wang Zhaoming Wang Nicolas Wentzensen William Wheeler Emily White John K. Wiencke Brian M. Wolpin Maria Pik Wong Chen Wu Tangchun Wu Xifeng Wu Yi-Long Wu Jay S. Wunder Lucy Xia Hannah P. Yang Pan-Chyr Yang Kai Yu Krista A. Zanetti Anne Zeleniuch-Jacquotte Wei Zheng Baosen Zhou Regina G. Ziegler Luis A. Perez-Jurado Neil E. Caporaso Nathaniel Rothman Margaret Tucker Michael C. Dean Meredith Yeager Stephen J. Chanock |
| author_sort |
Mitchell J. Machiela |
| title |
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome |
| title_short |
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome |
| title_full |
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome |
| title_fullStr |
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome |
| title_full_unstemmed |
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome |
| title_sort |
female chromosome x mosaicism is age-related and preferentially affects the inactivated x chromosome |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/ff910db139f74f1fb230ff9dacdc3391 |
| work_keys_str_mv |
AT mitchelljmachiela femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT weiyinzhou femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT erickarlins femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT joshuansampson femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT nealdfreedman femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT qiyang femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT belyndahicks femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT caseydagnall femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT christopherhautman femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT kevinbjacobs femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT christiancabnet femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT melindacaldrich femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT christopheramos femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT laufeytamundadottir femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT alanaarslan femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT lauraebeanefreeman femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT sonjaiberndt femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT amandablack femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT williamjblot femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT cathrynhbock femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT paigembracci femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT louiseabrinton femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT hbasbuenodemesquita femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT laurieburdett femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT julieeburing femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT maryabutler femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT federicocanzian femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT taniacarreon femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT karigchaffee femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT ishouchang femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT nilanjanchatterjee femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT chuchen femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT constancechen femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT kexinchen femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT charlescchung femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT lindascook femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT martacrousbou femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT michaelcullen femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT faithgdavis femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT immaculatadevivo femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT tiding femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT jenniferdoherty femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT ericjduell femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT carolinegepstein femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT jinhufan femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT joninedfigueroa femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT josephffraumeni femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT christinemfriedenreich femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT charlessfuchs femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT stevengallinger femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT yutanggao femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT susanmgapstur femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT montserratgarciaclosas femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT miamgaudet femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT jmichaelgaziano femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT grahamggiles femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT elizabethmgillanders femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT edwardlgiovannucci femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT lynngoldin femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT alisamgoldstein femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT christopherahaiman femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT goranhallmans femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT susanehankinson femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT curtischarris femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT rogerhenriksson femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT elizabethaholly femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT yunchulhong femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT robertnhoover femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT chaoahsiung femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT nanhu femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT weihu femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT davidjhunter femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT amyhutchinson femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT mazdajenab femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT christofferjohansen femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT kayteekhaw femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT heenamkim femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT yeulhongkim femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT youngtaekim femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT alisonpklein femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT robertklein femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT woonpuaykoh femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT laurencenkolonel femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT charleskooperberg femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT peterkraft femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT vittoriokrogh femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT robertckurtz femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT andrealacroix femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT qinglan femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT mariateresalandi femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT loiclemarchand femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT donghuili femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT xiaolinliang femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT lindamliao femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT dongxinlin femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT jianjunliu femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT jolantalissowska femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT lingenglu femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT anthonymmagliocco femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT nuriamalats femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT keitaromatsuo femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT lornahmcneill femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT robertrmcwilliams femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT beatricesmelin femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT lisamirabello femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT leemoore femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT saraholson femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT ireneorlow femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT jaeyongpark femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT anapatinogarcia femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT beatapeplonska femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT ulrikepeters femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT gloriampetersen femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT loreallpooler femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT jenniferprescott femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT ludmilaprokuninaolsson femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT markppurdue femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT youlinqiao femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT preetharajaraman femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT franciscoxreal femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT elioriboli femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT harveyarisch femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT benjaminrodriguezsantiago femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT avimamruder femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT sharonasavage femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT fredrickschumacher femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT anngschwartz femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT kendralschwartz femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT adelineseow femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT veronicawendysetiawan femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT gianlucaseveri femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT hongbingshen femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT xinsheng femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT minhoshin femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT xiaooushu femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT debratsilverman femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT margaretrspitz femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT victorialstevens femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT rachaelstolzenbergsolomon femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT danielstram femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT zezhongtang femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT philiprtaylor femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT laurenrteras femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT geoffreystobias femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT davidvandenberg femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT kalavisvanathan femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT sholomwacholder femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT jiucunwang femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT zhaomingwang femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT nicolaswentzensen femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT williamwheeler femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT emilywhite femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT johnkwiencke femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT brianmwolpin femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT mariapikwong femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT chenwu femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT tangchunwu femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT xifengwu femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT yilongwu femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT jayswunder femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT lucyxia femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT hannahpyang femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT panchyryang femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT kaiyu femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT kristaazanetti femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT annezeleniuchjacquotte femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT weizheng femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT baosenzhou femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT reginagziegler femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT luisaperezjurado femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT neilecaporaso femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT nathanielrothman femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT margarettucker femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT michaelcdean femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT meredithyeager femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome AT stephenjchanock femalechromosomexmosaicismisagerelatedandpreferentiallyaffectstheinactivatedxchromosome |
| _version_ |
1718386512280682496 |