Simultaneous and stoichiometric purification of hundreds of oligonucleotides

Chemically synthesized DNA oligonucleotides (oligos) require purification to remove truncated species. Here, the authors developed a high-throughput method for oligo purification that also normalises the concentrations of the oligos in the final samples.

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Detalles Bibliográficos
Autores principales:	Alessandro Pinto, Sherry X. Chen, David Yu Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ff9369e024ac4f13b1f3c810f3d60847
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spelling	oai:doaj.org-article:ff9369e024ac4f13b1f3c810f3d608472021-12-02T15:34:21ZSimultaneous and stoichiometric purification of hundreds of oligonucleotides10.1038/s41467-018-04870-w2041-1723https://doaj.org/article/ff9369e024ac4f13b1f3c810f3d608472018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04870-whttps://doaj.org/toc/2041-1723Chemically synthesized DNA oligonucleotides (oligos) require purification to remove truncated species. Here, the authors developed a high-throughput method for oligo purification that also normalises the concentrations of the oligos in the final samples.Alessandro PintoSherry X. ChenDavid Yu ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessandro Pinto Sherry X. Chen David Yu Zhang Simultaneous and stoichiometric purification of hundreds of oligonucleotides
description	Chemically synthesized DNA oligonucleotides (oligos) require purification to remove truncated species. Here, the authors developed a high-throughput method for oligo purification that also normalises the concentrations of the oligos in the final samples.
format	article
author	Alessandro Pinto Sherry X. Chen David Yu Zhang
author_facet	Alessandro Pinto Sherry X. Chen David Yu Zhang
author_sort	Alessandro Pinto
title	Simultaneous and stoichiometric purification of hundreds of oligonucleotides
title_short	Simultaneous and stoichiometric purification of hundreds of oligonucleotides
title_full	Simultaneous and stoichiometric purification of hundreds of oligonucleotides
title_fullStr	Simultaneous and stoichiometric purification of hundreds of oligonucleotides
title_full_unstemmed	Simultaneous and stoichiometric purification of hundreds of oligonucleotides
title_sort	simultaneous and stoichiometric purification of hundreds of oligonucleotides
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ff9369e024ac4f13b1f3c810f3d60847
work_keys_str_mv	AT alessandropinto simultaneousandstoichiometricpurificationofhundredsofoligonucleotides AT sherryxchen simultaneousandstoichiometricpurificationofhundredsofoligonucleotides AT davidyuzhang simultaneousandstoichiometricpurificationofhundredsofoligonucleotides
_version_	1718386879695421440

Simultaneous and stoichiometric purification of hundreds of oligonucleotides

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