Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime

Abstract To determine the pathophysiology of nocturnal polyuria associated with renal dysfunction, patients who underwent laparoscopic nephrectomy were prospectively studied. The diurnal variation in urine volume, osmolality, and salt excretion were measured on preoperative day 2 and postoperative d...

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Autores principales:	Kentaro Takezawa, Sohei Kuribayashi, Koichi Okada, Yosuke Sekii, Yusuke Inagaki, Shinichiro Fukuhara, Hiroshi Kiuchi, Toyofumi Abe, Kazutoshi Fujita, Motohide Uemura, Ryoichi Imamura, Norio Nonomura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ff9408ddf8ef42ebbfcd259c2b8f39bc
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spelling	oai:doaj.org-article:ff9408ddf8ef42ebbfcd259c2b8f39bc2021-12-02T16:49:37ZDecreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime10.1038/s41598-021-90166-x2045-2322https://doaj.org/article/ff9408ddf8ef42ebbfcd259c2b8f39bc2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90166-xhttps://doaj.org/toc/2045-2322Abstract To determine the pathophysiology of nocturnal polyuria associated with renal dysfunction, patients who underwent laparoscopic nephrectomy were prospectively studied. The diurnal variation in urine volume, osmolality, and salt excretion were measured on preoperative day 2 and postoperative day 7. The factors associated with an increase in the nighttime urine volume rate with decreased renal function were evaluated using multiple linear regression analysis. Forty-nine patients were included. The estimated glomerular filtration rate decreased from 73.3 ± 2.0 to 47.2 ± 1.6 mL/min/1.73 m2 (P < 0.01) and the nighttime urine volume rate increased from 40.6% ± 2.0% to 45.3% ± 1.5% (P = 0.04) with nephrectomy. The nighttime urine osmolality decreased from 273 ± 15 to 212 ± 10 mOsm/kg and the nighttime salt excretion rate increased from 38.7% ± 2.1% to 48.8% ± 1.7% (both P < 0.01) with nephrectomy. Multiple linear regression analysis showed that the increase in the nighttime urine volume rate was strongly affected by the increase in the nighttime salt excretion rate. A decrease in renal function causes an increase in the nighttime urine volume rate, mainly because of an increase in nighttime salt excretion. Trial registration number: UMIN000036760 (University Hospital Medical Information Network Clinical Trials Registry). Date of registration: From 1 June 2019 to 31 October 2020.Kentaro TakezawaSohei KuribayashiKoichi OkadaYosuke SekiiYusuke InagakiShinichiro FukuharaHiroshi KiuchiToyofumi AbeKazutoshi FujitaMotohide UemuraRyoichi ImamuraNorio NonomuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kentaro Takezawa Sohei Kuribayashi Koichi Okada Yosuke Sekii Yusuke Inagaki Shinichiro Fukuhara Hiroshi Kiuchi Toyofumi Abe Kazutoshi Fujita Motohide Uemura Ryoichi Imamura Norio Nonomura Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime
description	Abstract To determine the pathophysiology of nocturnal polyuria associated with renal dysfunction, patients who underwent laparoscopic nephrectomy were prospectively studied. The diurnal variation in urine volume, osmolality, and salt excretion were measured on preoperative day 2 and postoperative day 7. The factors associated with an increase in the nighttime urine volume rate with decreased renal function were evaluated using multiple linear regression analysis. Forty-nine patients were included. The estimated glomerular filtration rate decreased from 73.3 ± 2.0 to 47.2 ± 1.6 mL/min/1.73 m2 (P < 0.01) and the nighttime urine volume rate increased from 40.6% ± 2.0% to 45.3% ± 1.5% (P = 0.04) with nephrectomy. The nighttime urine osmolality decreased from 273 ± 15 to 212 ± 10 mOsm/kg and the nighttime salt excretion rate increased from 38.7% ± 2.1% to 48.8% ± 1.7% (both P < 0.01) with nephrectomy. Multiple linear regression analysis showed that the increase in the nighttime urine volume rate was strongly affected by the increase in the nighttime salt excretion rate. A decrease in renal function causes an increase in the nighttime urine volume rate, mainly because of an increase in nighttime salt excretion. Trial registration number: UMIN000036760 (University Hospital Medical Information Network Clinical Trials Registry). Date of registration: From 1 June 2019 to 31 October 2020.
format	article
author	Kentaro Takezawa Sohei Kuribayashi Koichi Okada Yosuke Sekii Yusuke Inagaki Shinichiro Fukuhara Hiroshi Kiuchi Toyofumi Abe Kazutoshi Fujita Motohide Uemura Ryoichi Imamura Norio Nonomura
author_facet	Kentaro Takezawa Sohei Kuribayashi Koichi Okada Yosuke Sekii Yusuke Inagaki Shinichiro Fukuhara Hiroshi Kiuchi Toyofumi Abe Kazutoshi Fujita Motohide Uemura Ryoichi Imamura Norio Nonomura
author_sort	Kentaro Takezawa
title	Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime
title_short	Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime
title_full	Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime
title_fullStr	Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime
title_full_unstemmed	Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime
title_sort	decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ff9408ddf8ef42ebbfcd259c2b8f39bc
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Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime

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