Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction

Chimeric antigen receptor engineering in T cells has been shown to be of great potential therapeutic benefit in a range of immune pathologies, although the functionality of such cell therapies can be limited due to tonic signalling and the induction of dysfunction. Here the authors show transient in...

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Autores principales:	Baptiste Lamarthée, Armance Marchal, Soëli Charbonnier, Tifanie Blein, Juliette Leon, Emmanuel Martin, Lucas Rabaux, Katrin Vogt, Matthias Titeux, Marianne Delville, Hélène Vinçon, Emmanuelle Six, Nicolas Pallet, David Michonneau, Dany Anglicheau, Christophe Legendre, Jean-Luc Taupin, Ivan Nemazanyy, Birgit Sawitzki, Sylvain Latour, Marina Cavazzana, Isabelle André, Julien Zuber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ff953c0676e145dc93bb84de2244c04f
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spelling	oai:doaj.org-article:ff953c0676e145dc93bb84de2244c04f2021-11-14T12:34:45ZTransient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction10.1038/s41467-021-26844-12041-1723https://doaj.org/article/ff953c0676e145dc93bb84de2244c04f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26844-1https://doaj.org/toc/2041-1723Chimeric antigen receptor engineering in T cells has been shown to be of great potential therapeutic benefit in a range of immune pathologies, although the functionality of such cell therapies can be limited due to tonic signalling and the induction of dysfunction. Here the authors show transient inhibition of mTOR can rescue their 41-BB-CAR-Tregs from tonic signalling-induced dysfunction.Baptiste LamarthéeArmance MarchalSoëli CharbonnierTifanie BleinJuliette LeonEmmanuel MartinLucas RabauxKatrin VogtMatthias TiteuxMarianne DelvilleHélène VinçonEmmanuelle SixNicolas PalletDavid MichonneauDany AnglicheauChristophe LegendreJean-Luc TaupinIvan NemazanyyBirgit SawitzkiSylvain LatourMarina CavazzanaIsabelle AndréJulien ZuberNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Baptiste Lamarthée Armance Marchal Soëli Charbonnier Tifanie Blein Juliette Leon Emmanuel Martin Lucas Rabaux Katrin Vogt Matthias Titeux Marianne Delville Hélène Vinçon Emmanuelle Six Nicolas Pallet David Michonneau Dany Anglicheau Christophe Legendre Jean-Luc Taupin Ivan Nemazanyy Birgit Sawitzki Sylvain Latour Marina Cavazzana Isabelle André Julien Zuber Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction
description	Chimeric antigen receptor engineering in T cells has been shown to be of great potential therapeutic benefit in a range of immune pathologies, although the functionality of such cell therapies can be limited due to tonic signalling and the induction of dysfunction. Here the authors show transient inhibition of mTOR can rescue their 41-BB-CAR-Tregs from tonic signalling-induced dysfunction.
format	article
author	Baptiste Lamarthée Armance Marchal Soëli Charbonnier Tifanie Blein Juliette Leon Emmanuel Martin Lucas Rabaux Katrin Vogt Matthias Titeux Marianne Delville Hélène Vinçon Emmanuelle Six Nicolas Pallet David Michonneau Dany Anglicheau Christophe Legendre Jean-Luc Taupin Ivan Nemazanyy Birgit Sawitzki Sylvain Latour Marina Cavazzana Isabelle André Julien Zuber
author_facet	Baptiste Lamarthée Armance Marchal Soëli Charbonnier Tifanie Blein Juliette Leon Emmanuel Martin Lucas Rabaux Katrin Vogt Matthias Titeux Marianne Delville Hélène Vinçon Emmanuelle Six Nicolas Pallet David Michonneau Dany Anglicheau Christophe Legendre Jean-Luc Taupin Ivan Nemazanyy Birgit Sawitzki Sylvain Latour Marina Cavazzana Isabelle André Julien Zuber
author_sort	Baptiste Lamarthée
title	Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction
title_short	Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction
title_full	Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction
title_fullStr	Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction
title_full_unstemmed	Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction
title_sort	transient mtor inhibition rescues 4-1bb car-tregs from tonic signal-induced dysfunction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ff953c0676e145dc93bb84de2244c04f
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Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction

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