Impaired Innate Immunity in Pediatric Patients Type 1 Diabetes—Focus on Toll-like Receptors Expression

Type 1 diabetes (DM1) is classified as an autoimmune disease. An uncontrolled response of B and T lymphocytes to the body’s own tissues develops in the absence of immune tolerance. The main aim of the study was to evaluate the effect of the duration of type 1 diabetes in children on the expression o...

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Autores principales:	Katarzyna Kurianowicz, Maria Klatka, Agnieszka Polak, Anna Hymos, Dominika Bębnowska, Martyna Podgajna, Rafał Hrynkiewicz, Olga Sierawska, Paulina Niedźwiedzka-Rystwej
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	type 1 diabetes mellitus children Toll-like receptors Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ff96d719b82947b197ef498aa2ecace0
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spelling	oai:doaj.org-article:ff96d719b82947b197ef498aa2ecace02021-11-25T17:53:42ZImpaired Innate Immunity in Pediatric Patients Type 1 Diabetes—Focus on Toll-like Receptors Expression10.3390/ijms2222121351422-00671661-6596https://doaj.org/article/ff96d719b82947b197ef498aa2ecace02021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12135https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Type 1 diabetes (DM1) is classified as an autoimmune disease. An uncontrolled response of B and T lymphocytes to the body’s own tissues develops in the absence of immune tolerance. The main aim of the study was to evaluate the effect of the duration of type 1 diabetes in children on the expression of TLR receptors and the relationship with the parameters of glycemic control in patients. As a result, we showed significant differences in the level of TLR2, TLR4 and TLR9 expression in patients with DM1 in the early stage of the disease and treated chronically compared to the healthy group. Additionally, in this study, we found that the numbers of CD19+ B cells, CD3+ CD4+, CD3+ CD8+ T cells and NK cells are different for newly diagnosed DM1 individuals, patients receiving chronic treatment and for healthy controls, indicating an important role of these cells in killing pancreatic beta cells. Moreover, higher levels of IL-10 in patients with newly diagnosed DM1 have also been found, confirming the reports found in the literature.Katarzyna KurianowiczMaria KlatkaAgnieszka PolakAnna HymosDominika BębnowskaMartyna PodgajnaRafał HrynkiewiczOlga SierawskaPaulina Niedźwiedzka-RystwejMDPI AGarticletype 1 diabetes mellituschildrenToll-like receptorsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12135, p 12135 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 1 diabetes mellitus children Toll-like receptors Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	type 1 diabetes mellitus children Toll-like receptors Biology (General) QH301-705.5 Chemistry QD1-999 Katarzyna Kurianowicz Maria Klatka Agnieszka Polak Anna Hymos Dominika Bębnowska Martyna Podgajna Rafał Hrynkiewicz Olga Sierawska Paulina Niedźwiedzka-Rystwej Impaired Innate Immunity in Pediatric Patients Type 1 Diabetes—Focus on Toll-like Receptors Expression
description	Type 1 diabetes (DM1) is classified as an autoimmune disease. An uncontrolled response of B and T lymphocytes to the body’s own tissues develops in the absence of immune tolerance. The main aim of the study was to evaluate the effect of the duration of type 1 diabetes in children on the expression of TLR receptors and the relationship with the parameters of glycemic control in patients. As a result, we showed significant differences in the level of TLR2, TLR4 and TLR9 expression in patients with DM1 in the early stage of the disease and treated chronically compared to the healthy group. Additionally, in this study, we found that the numbers of CD19+ B cells, CD3+ CD4+, CD3+ CD8+ T cells and NK cells are different for newly diagnosed DM1 individuals, patients receiving chronic treatment and for healthy controls, indicating an important role of these cells in killing pancreatic beta cells. Moreover, higher levels of IL-10 in patients with newly diagnosed DM1 have also been found, confirming the reports found in the literature.
format	article
author	Katarzyna Kurianowicz Maria Klatka Agnieszka Polak Anna Hymos Dominika Bębnowska Martyna Podgajna Rafał Hrynkiewicz Olga Sierawska Paulina Niedźwiedzka-Rystwej
author_facet	Katarzyna Kurianowicz Maria Klatka Agnieszka Polak Anna Hymos Dominika Bębnowska Martyna Podgajna Rafał Hrynkiewicz Olga Sierawska Paulina Niedźwiedzka-Rystwej
author_sort	Katarzyna Kurianowicz
title	Impaired Innate Immunity in Pediatric Patients Type 1 Diabetes—Focus on Toll-like Receptors Expression
title_short	Impaired Innate Immunity in Pediatric Patients Type 1 Diabetes—Focus on Toll-like Receptors Expression
title_full	Impaired Innate Immunity in Pediatric Patients Type 1 Diabetes—Focus on Toll-like Receptors Expression
title_fullStr	Impaired Innate Immunity in Pediatric Patients Type 1 Diabetes—Focus on Toll-like Receptors Expression
title_full_unstemmed	Impaired Innate Immunity in Pediatric Patients Type 1 Diabetes—Focus on Toll-like Receptors Expression
title_sort	impaired innate immunity in pediatric patients type 1 diabetes—focus on toll-like receptors expression
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ff96d719b82947b197ef498aa2ecace0
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Impaired Innate Immunity in Pediatric Patients Type 1 Diabetes—Focus on Toll-like Receptors Expression

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