Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP

ATP can function as a biological hydrotrope, but its global effects on protein solubility have not yet been characterized. Here, the authors quantify the effect of ATP on the thermal stability and solubility of the cellular proteome, providing insights into protein solubility regulation by ATP.

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Autores principales:	Sindhuja Sridharan, Nils Kurzawa, Thilo Werner, Ina Günthner, Dominic Helm, Wolfgang Huber, Marcus Bantscheff, Mikhail M. Savitski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ff98a6a32ee842a08a683497e2739586
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spelling	oai:doaj.org-article:ff98a6a32ee842a08a683497e27395862021-12-02T15:35:40ZProteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP10.1038/s41467-019-09107-y2041-1723https://doaj.org/article/ff98a6a32ee842a08a683497e27395862019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09107-yhttps://doaj.org/toc/2041-1723ATP can function as a biological hydrotrope, but its global effects on protein solubility have not yet been characterized. Here, the authors quantify the effect of ATP on the thermal stability and solubility of the cellular proteome, providing insights into protein solubility regulation by ATP.Sindhuja SridharanNils KurzawaThilo WernerIna GünthnerDominic HelmWolfgang HuberMarcus BantscheffMikhail M. SavitskiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sindhuja Sridharan Nils Kurzawa Thilo Werner Ina Günthner Dominic Helm Wolfgang Huber Marcus Bantscheff Mikhail M. Savitski Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP
description	ATP can function as a biological hydrotrope, but its global effects on protein solubility have not yet been characterized. Here, the authors quantify the effect of ATP on the thermal stability and solubility of the cellular proteome, providing insights into protein solubility regulation by ATP.
format	article
author	Sindhuja Sridharan Nils Kurzawa Thilo Werner Ina Günthner Dominic Helm Wolfgang Huber Marcus Bantscheff Mikhail M. Savitski
author_facet	Sindhuja Sridharan Nils Kurzawa Thilo Werner Ina Günthner Dominic Helm Wolfgang Huber Marcus Bantscheff Mikhail M. Savitski
author_sort	Sindhuja Sridharan
title	Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP
title_short	Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP
title_full	Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP
title_fullStr	Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP
title_full_unstemmed	Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP
title_sort	proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for atp
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ff98a6a32ee842a08a683497e2739586
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Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP

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