Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis

Helicobacter pylori FabX, a dehydrogenase/isomerase flavoprotein, is required for unsaturated fatty acid synthesis. Here, the authors characterize FabX substrate recognition and catalytic mechanism, and reveal that it contains an atypical [4Fe-4S] cluster, which is essential and participates in the...

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Auteurs principaux:	Jiashen Zhou, Lin Zhang, Liping Zeng, Lu Yu, Yuanyuan Duan, Siqi Shen, Jingyan Hu, Pan Zhang, Wenyan Song, Xiaoxue Ruan, Jing Jiang, Yinan Zhang, Lu Zhou, Jia Jia, Xudong Hang, Changlin Tian, Houwen Lin, Hong-Zhuan Chen, John E. Cronan, Hongkai Bi, Liang Zhang
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/ff98c86182784a2baf66ddf02f8bcbf9
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spelling	oai:doaj.org-article:ff98c86182784a2baf66ddf02f8bcbf92021-11-28T12:33:37ZHelicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis10.1038/s41467-021-27148-02041-1723https://doaj.org/article/ff98c86182784a2baf66ddf02f8bcbf92021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27148-0https://doaj.org/toc/2041-1723Helicobacter pylori FabX, a dehydrogenase/isomerase flavoprotein, is required for unsaturated fatty acid synthesis. Here, the authors characterize FabX substrate recognition and catalytic mechanism, and reveal that it contains an atypical [4Fe-4S] cluster, which is essential and participates in the catalytic cycle.Jiashen ZhouLin ZhangLiping ZengLu YuYuanyuan DuanSiqi ShenJingyan HuPan ZhangWenyan SongXiaoxue RuanJing JiangYinan ZhangLu ZhouJia JiaXudong HangChanglin TianHouwen LinHong-Zhuan ChenJohn E. CronanHongkai BiLiang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiashen Zhou Lin Zhang Liping Zeng Lu Yu Yuanyuan Duan Siqi Shen Jingyan Hu Pan Zhang Wenyan Song Xiaoxue Ruan Jing Jiang Yinan Zhang Lu Zhou Jia Jia Xudong Hang Changlin Tian Houwen Lin Hong-Zhuan Chen John E. Cronan Hongkai Bi Liang Zhang Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis
description	Helicobacter pylori FabX, a dehydrogenase/isomerase flavoprotein, is required for unsaturated fatty acid synthesis. Here, the authors characterize FabX substrate recognition and catalytic mechanism, and reveal that it contains an atypical [4Fe-4S] cluster, which is essential and participates in the catalytic cycle.
format	article
author	Jiashen Zhou Lin Zhang Liping Zeng Lu Yu Yuanyuan Duan Siqi Shen Jingyan Hu Pan Zhang Wenyan Song Xiaoxue Ruan Jing Jiang Yinan Zhang Lu Zhou Jia Jia Xudong Hang Changlin Tian Houwen Lin Hong-Zhuan Chen John E. Cronan Hongkai Bi Liang Zhang
author_facet	Jiashen Zhou Lin Zhang Liping Zeng Lu Yu Yuanyuan Duan Siqi Shen Jingyan Hu Pan Zhang Wenyan Song Xiaoxue Ruan Jing Jiang Yinan Zhang Lu Zhou Jia Jia Xudong Hang Changlin Tian Houwen Lin Hong-Zhuan Chen John E. Cronan Hongkai Bi Liang Zhang
author_sort	Jiashen Zhou
title	Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis
title_short	Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis
title_full	Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis
title_fullStr	Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis
title_full_unstemmed	Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis
title_sort	helicobacter pylori fabx contains a [4fe-4s] cluster essential for unsaturated fatty acid synthesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ff98c86182784a2baf66ddf02f8bcbf9
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Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis

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