Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis

Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis

Helicobacter pylori FabX, a dehydrogenase/isomerase flavoprotein, is required for unsaturated fatty acid synthesis. Here, the authors characterize FabX substrate recognition and catalytic mechanism, and reveal that it contains an atypical [4Fe-4S] cluster, which is essential and participates in the...

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Autores principales: Jiashen Zhou, Lin Zhang, Liping Zeng, Lu Yu, Yuanyuan Duan, Siqi Shen, Jingyan Hu, Pan Zhang, Wenyan Song, Xiaoxue Ruan, Jing Jiang, Yinan Zhang, Lu Zhou, Jia Jia, Xudong Hang, Changlin Tian, Houwen Lin, Hong-Zhuan Chen, John E. Cronan, Hongkai Bi, Liang Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/ff98c86182784a2baf66ddf02f8bcbf9
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spelling oai:doaj.org-article:ff98c86182784a2baf66ddf02f8bcbf92021-11-28T12:33:37ZHelicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis10.1038/s41467-021-27148-02041-1723https://doaj.org/article/ff98c86182784a2baf66ddf02f8bcbf92021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27148-0https://doaj.org/toc/2041-1723Helicobacter pylori FabX, a dehydrogenase/isomerase flavoprotein, is required for unsaturated fatty acid synthesis. Here, the authors characterize FabX substrate recognition and catalytic mechanism, and reveal that it contains an atypical [4Fe-4S] cluster, which is essential and participates in the catalytic cycle.Jiashen ZhouLin ZhangLiping ZengLu YuYuanyuan DuanSiqi ShenJingyan HuPan ZhangWenyan SongXiaoxue RuanJing JiangYinan ZhangLu ZhouJia JiaXudong HangChanglin TianHouwen LinHong-Zhuan ChenJohn E. CronanHongkai BiLiang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jiashen Zhou
Lin Zhang
Liping Zeng
Lu Yu
Yuanyuan Duan
Siqi Shen
Jingyan Hu
Pan Zhang
Wenyan Song
Xiaoxue Ruan
Jing Jiang
Yinan Zhang
Lu Zhou
Jia Jia
Xudong Hang
Changlin Tian
Houwen Lin
Hong-Zhuan Chen
John E. Cronan
Hongkai Bi
Liang Zhang
Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis
description Helicobacter pylori FabX, a dehydrogenase/isomerase flavoprotein, is required for unsaturated fatty acid synthesis. Here, the authors characterize FabX substrate recognition and catalytic mechanism, and reveal that it contains an atypical [4Fe-4S] cluster, which is essential and participates in the catalytic cycle.
format article
author Jiashen Zhou
Lin Zhang
Liping Zeng
Lu Yu
Yuanyuan Duan
Siqi Shen
Jingyan Hu
Pan Zhang
Wenyan Song
Xiaoxue Ruan
Jing Jiang
Yinan Zhang
Lu Zhou
Jia Jia
Xudong Hang
Changlin Tian
Houwen Lin
Hong-Zhuan Chen
John E. Cronan
Hongkai Bi
Liang Zhang
author_facet Jiashen Zhou
Lin Zhang
Liping Zeng
Lu Yu
Yuanyuan Duan
Siqi Shen
Jingyan Hu
Pan Zhang
Wenyan Song
Xiaoxue Ruan
Jing Jiang
Yinan Zhang
Lu Zhou
Jia Jia
Xudong Hang
Changlin Tian
Houwen Lin
Hong-Zhuan Chen
John E. Cronan
Hongkai Bi
Liang Zhang
author_sort Jiashen Zhou
title Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis
title_short Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis
title_full Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis
title_fullStr Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis
title_full_unstemmed Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis
title_sort helicobacter pylori fabx contains a [4fe-4s] cluster essential for unsaturated fatty acid synthesis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ff98c86182784a2baf66ddf02f8bcbf9
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