Grey matter correlates of three language tests in non-demented older adults.

Language has been extensively investigated by functional neuroimaging studies. However, only a limited number of structural neuroimaging studies have examined the relationship between language performance and brain structure in healthy adults, and the number is even less in older adults. The present...

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Autores principales:	Haobo Zhang, Perminder S Sachdev, Wei Wen, Nicole A Kochan, John D Crawford, Henry Brodaty, Melissa J Slavin, Simone Reppermund, Kristan Kang, Julian N Trollor
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ff98f06fb1744cc2bb22d5295d113776
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spelling	oai:doaj.org-article:ff98f06fb1744cc2bb22d5295d1137762021-11-18T08:48:13ZGrey matter correlates of three language tests in non-demented older adults.1932-620310.1371/journal.pone.0080215https://doaj.org/article/ff98f06fb1744cc2bb22d5295d1137762013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24224044/?tool=EBIhttps://doaj.org/toc/1932-6203Language has been extensively investigated by functional neuroimaging studies. However, only a limited number of structural neuroimaging studies have examined the relationship between language performance and brain structure in healthy adults, and the number is even less in older adults. The present study sought to investigate correlations between grey matter volumes and three standardized language tests in late life. The participants were 344 non-demented, community-dwelling adults aged 70-90 years, who were drawn from the population-based Sydney Memory and Ageing Study. The three language tests included the Controlled Oral Word Association Task (COWAT), Category Fluency (CF), and Boston Naming Test (BNT). Correlation analyses between voxel-wise GM volumes and language tests showed distinctive GM correlation patterns for each language test. The GM correlates were located in the right frontal and left temporal lobes for COWAT, in the left frontal and temporal lobes for CF, and in bilateral temporal lobes for BNT. Our findings largely corresponded to the neural substrates of language tasks revealed in fMRI studies, and we also observed a less hemispheric asymmetry in the GM correlates of the language tests. Furthermore, we divided the participants into two age groups (70-79 and 80-90 years old), and then examined the correlations between structural laterality indices and language performance for each group. A trend toward significant difference in the correlations was found between the two age groups, with stronger correlations in the group of 70-79 years old than those in the group of 80-90 years old. This difference might suggest a further decline of language lateralization in different stages of late life.Haobo ZhangPerminder S SachdevWei WenNicole A KochanJohn D CrawfordHenry BrodatyMelissa J SlavinSimone ReppermundKristan KangJulian N TrollorPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80215 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Haobo Zhang Perminder S Sachdev Wei Wen Nicole A Kochan John D Crawford Henry Brodaty Melissa J Slavin Simone Reppermund Kristan Kang Julian N Trollor Grey matter correlates of three language tests in non-demented older adults.
description	Language has been extensively investigated by functional neuroimaging studies. However, only a limited number of structural neuroimaging studies have examined the relationship between language performance and brain structure in healthy adults, and the number is even less in older adults. The present study sought to investigate correlations between grey matter volumes and three standardized language tests in late life. The participants were 344 non-demented, community-dwelling adults aged 70-90 years, who were drawn from the population-based Sydney Memory and Ageing Study. The three language tests included the Controlled Oral Word Association Task (COWAT), Category Fluency (CF), and Boston Naming Test (BNT). Correlation analyses between voxel-wise GM volumes and language tests showed distinctive GM correlation patterns for each language test. The GM correlates were located in the right frontal and left temporal lobes for COWAT, in the left frontal and temporal lobes for CF, and in bilateral temporal lobes for BNT. Our findings largely corresponded to the neural substrates of language tasks revealed in fMRI studies, and we also observed a less hemispheric asymmetry in the GM correlates of the language tests. Furthermore, we divided the participants into two age groups (70-79 and 80-90 years old), and then examined the correlations between structural laterality indices and language performance for each group. A trend toward significant difference in the correlations was found between the two age groups, with stronger correlations in the group of 70-79 years old than those in the group of 80-90 years old. This difference might suggest a further decline of language lateralization in different stages of late life.
format	article
author	Haobo Zhang Perminder S Sachdev Wei Wen Nicole A Kochan John D Crawford Henry Brodaty Melissa J Slavin Simone Reppermund Kristan Kang Julian N Trollor
author_facet	Haobo Zhang Perminder S Sachdev Wei Wen Nicole A Kochan John D Crawford Henry Brodaty Melissa J Slavin Simone Reppermund Kristan Kang Julian N Trollor
author_sort	Haobo Zhang
title	Grey matter correlates of three language tests in non-demented older adults.
title_short	Grey matter correlates of three language tests in non-demented older adults.
title_full	Grey matter correlates of three language tests in non-demented older adults.
title_fullStr	Grey matter correlates of three language tests in non-demented older adults.
title_full_unstemmed	Grey matter correlates of three language tests in non-demented older adults.
title_sort	grey matter correlates of three language tests in non-demented older adults.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ff98f06fb1744cc2bb22d5295d113776
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Grey matter correlates of three language tests in non-demented older adults.

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