Structures of Medicago truncatula L-Histidinol Dehydrogenase Show Rearrangements Required for NAD+ Binding and the Cofactor Positioned to Accept a Hydride
Abstract Plants, lower eukaryotes, bacteria, and archaebacteria synthesise L-histidine (His) in a similar, multistep pathway that is absent in mammals. This makes the His biosynthetic route a promising target for herbicides, antifungal agents, and antibiotics. The last enzyme of the pathway, bifunct...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
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Nature Portfolio
2017
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/ff9b75a0a4d44e0a9b804979d0e0d119 |
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