The protective role of lutein on isoproterenol-induced cardiac failure rat model through improving cardiac morphology, antioxidant status via positively regulating Nrf2/HO-1 signalling pathway

Context: Lutein (LU) is a major carotenoid with various pharmacological activities including anti-inflammatory, antioxidant and anti-apoptosis. Objective: The cardioprotective efficacy of LU was determined by evaluating the biochemical and histopathological changes in isoproterenol (ISO) induced myo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bo Ouyang, Zili Li, Xiongying Ji, Jiangwei Huang, Hengsheng Zhang, Changrong Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	myocardial infarction infarct size cardioprotective cardiac markers Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ff9d24e775c94fb394d567e9e19f48d2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ff9d24e775c94fb394d567e9e19f48d2
record_format	dspace
spelling	oai:doaj.org-article:ff9d24e775c94fb394d567e9e19f48d22021-11-17T14:21:56ZThe protective role of lutein on isoproterenol-induced cardiac failure rat model through improving cardiac morphology, antioxidant status via positively regulating Nrf2/HO-1 signalling pathway1388-02091744-511610.1080/13880209.2019.1649436https://doaj.org/article/ff9d24e775c94fb394d567e9e19f48d22019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2019.1649436https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: Lutein (LU) is a major carotenoid with various pharmacological activities including anti-inflammatory, antioxidant and anti-apoptosis. Objective: The cardioprotective efficacy of LU was determined by evaluating the biochemical and histopathological changes in isoproterenol (ISO) induced myocardial infarction (MI) rat model. Materials and methods: Healthy male albino rats (n = 40) were segregated into 4 equal groups. Group I (control) rats were administered with olive oil, Group II (LU) rats were orally pre-treated with only 40 mg of LU for 28 days, Group III (MI induced) rats were injected (subcutaneously; s.c) with 85 mg/kg of ISO for 2 consecutive days, whereas Group IV (LU + ISO) rats were pre-treated with 40 mg of LU for 28 days before ISO induction. Results: ISO-induced group showed increased infarct size and cardiac/inflammatory/apoptotic markers. However, pre-treatment with LU (28 days) considerably reduced (p < 0.01) the infarct size (14%), lipid peroxidation product (MDA;42%), cardiac markers [(lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB), cardiac troponin T (cTn T)], inflammatory markers [IL-1β, IL-6, tumour necrosis factor alpha (TNF-α), nuclear factor kappa B p65 subunit (NF-κB p65)] and apoptotic markers (caspase-3 and -9). Also, LU significantly improved (p < 0.01) the antioxidants [catalase (CAT), superoxide dismutase (SOD)] as well as markedly upregulated (p < 0.01) the protein expression of HO-1 and Nrf2. Moreover, LU considerably reversed all the histopathological changes and thus exhibits its cardioprotective activity. Conclusion: LU exhibits potent cardioprotective activity against ISO-induced cardiotoxicity and might be recommended with standard cardioprotective agents for treating various MI-related complications.Bo OuyangZili LiXiongying JiJiangwei HuangHengsheng ZhangChangrong JiangTaylor & Francis Grouparticlemyocardial infarctioninfarct sizecardioprotectivecardiac markersTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 529-535 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	myocardial infarction infarct size cardioprotective cardiac markers Therapeutics. Pharmacology RM1-950
spellingShingle	myocardial infarction infarct size cardioprotective cardiac markers Therapeutics. Pharmacology RM1-950 Bo Ouyang Zili Li Xiongying Ji Jiangwei Huang Hengsheng Zhang Changrong Jiang The protective role of lutein on isoproterenol-induced cardiac failure rat model through improving cardiac morphology, antioxidant status via positively regulating Nrf2/HO-1 signalling pathway
description	Context: Lutein (LU) is a major carotenoid with various pharmacological activities including anti-inflammatory, antioxidant and anti-apoptosis. Objective: The cardioprotective efficacy of LU was determined by evaluating the biochemical and histopathological changes in isoproterenol (ISO) induced myocardial infarction (MI) rat model. Materials and methods: Healthy male albino rats (n = 40) were segregated into 4 equal groups. Group I (control) rats were administered with olive oil, Group II (LU) rats were orally pre-treated with only 40 mg of LU for 28 days, Group III (MI induced) rats were injected (subcutaneously; s.c) with 85 mg/kg of ISO for 2 consecutive days, whereas Group IV (LU + ISO) rats were pre-treated with 40 mg of LU for 28 days before ISO induction. Results: ISO-induced group showed increased infarct size and cardiac/inflammatory/apoptotic markers. However, pre-treatment with LU (28 days) considerably reduced (p < 0.01) the infarct size (14%), lipid peroxidation product (MDA;42%), cardiac markers [(lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB), cardiac troponin T (cTn T)], inflammatory markers [IL-1β, IL-6, tumour necrosis factor alpha (TNF-α), nuclear factor kappa B p65 subunit (NF-κB p65)] and apoptotic markers (caspase-3 and -9). Also, LU significantly improved (p < 0.01) the antioxidants [catalase (CAT), superoxide dismutase (SOD)] as well as markedly upregulated (p < 0.01) the protein expression of HO-1 and Nrf2. Moreover, LU considerably reversed all the histopathological changes and thus exhibits its cardioprotective activity. Conclusion: LU exhibits potent cardioprotective activity against ISO-induced cardiotoxicity and might be recommended with standard cardioprotective agents for treating various MI-related complications.
format	article
author	Bo Ouyang Zili Li Xiongying Ji Jiangwei Huang Hengsheng Zhang Changrong Jiang
author_facet	Bo Ouyang Zili Li Xiongying Ji Jiangwei Huang Hengsheng Zhang Changrong Jiang
author_sort	Bo Ouyang
title	The protective role of lutein on isoproterenol-induced cardiac failure rat model through improving cardiac morphology, antioxidant status via positively regulating Nrf2/HO-1 signalling pathway
title_short	The protective role of lutein on isoproterenol-induced cardiac failure rat model through improving cardiac morphology, antioxidant status via positively regulating Nrf2/HO-1 signalling pathway
title_full	The protective role of lutein on isoproterenol-induced cardiac failure rat model through improving cardiac morphology, antioxidant status via positively regulating Nrf2/HO-1 signalling pathway
title_fullStr	The protective role of lutein on isoproterenol-induced cardiac failure rat model through improving cardiac morphology, antioxidant status via positively regulating Nrf2/HO-1 signalling pathway
title_full_unstemmed	The protective role of lutein on isoproterenol-induced cardiac failure rat model through improving cardiac morphology, antioxidant status via positively regulating Nrf2/HO-1 signalling pathway
title_sort	protective role of lutein on isoproterenol-induced cardiac failure rat model through improving cardiac morphology, antioxidant status via positively regulating nrf2/ho-1 signalling pathway
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/ff9d24e775c94fb394d567e9e19f48d2
work_keys_str_mv	AT boouyang theprotectiveroleofluteinonisoproterenolinducedcardiacfailureratmodelthroughimprovingcardiacmorphologyantioxidantstatusviapositivelyregulatingnrf2ho1signallingpathway AT zilili theprotectiveroleofluteinonisoproterenolinducedcardiacfailureratmodelthroughimprovingcardiacmorphologyantioxidantstatusviapositivelyregulatingnrf2ho1signallingpathway AT xiongyingji theprotectiveroleofluteinonisoproterenolinducedcardiacfailureratmodelthroughimprovingcardiacmorphologyantioxidantstatusviapositivelyregulatingnrf2ho1signallingpathway AT jiangweihuang theprotectiveroleofluteinonisoproterenolinducedcardiacfailureratmodelthroughimprovingcardiacmorphologyantioxidantstatusviapositivelyregulatingnrf2ho1signallingpathway AT hengshengzhang theprotectiveroleofluteinonisoproterenolinducedcardiacfailureratmodelthroughimprovingcardiacmorphologyantioxidantstatusviapositivelyregulatingnrf2ho1signallingpathway AT changrongjiang theprotectiveroleofluteinonisoproterenolinducedcardiacfailureratmodelthroughimprovingcardiacmorphologyantioxidantstatusviapositivelyregulatingnrf2ho1signallingpathway AT boouyang protectiveroleofluteinonisoproterenolinducedcardiacfailureratmodelthroughimprovingcardiacmorphologyantioxidantstatusviapositivelyregulatingnrf2ho1signallingpathway AT zilili protectiveroleofluteinonisoproterenolinducedcardiacfailureratmodelthroughimprovingcardiacmorphologyantioxidantstatusviapositivelyregulatingnrf2ho1signallingpathway AT xiongyingji protectiveroleofluteinonisoproterenolinducedcardiacfailureratmodelthroughimprovingcardiacmorphologyantioxidantstatusviapositivelyregulatingnrf2ho1signallingpathway AT jiangweihuang protectiveroleofluteinonisoproterenolinducedcardiacfailureratmodelthroughimprovingcardiacmorphologyantioxidantstatusviapositivelyregulatingnrf2ho1signallingpathway AT hengshengzhang protectiveroleofluteinonisoproterenolinducedcardiacfailureratmodelthroughimprovingcardiacmorphologyantioxidantstatusviapositivelyregulatingnrf2ho1signallingpathway AT changrongjiang protectiveroleofluteinonisoproterenolinducedcardiacfailureratmodelthroughimprovingcardiacmorphologyantioxidantstatusviapositivelyregulatingnrf2ho1signallingpathway
_version_	1718425524053737472

The protective role of lutein on isoproterenol-induced cardiac failure rat model through improving cardiac morphology, antioxidant status via positively regulating Nrf2/HO-1 signalling pathway

Ejemplares similares