Fluorogenic RNA Mango aptamers for imaging small non-coding RNAs in mammalian cells

Fluorogenic RNA Mango aptamers for imaging small non-coding RNAs in mammalian cells

Many aptamer-fluorophore complexes suffer from low quantum yield and low extinction coefficients limiting their usability. Here the authors isolate new Mango aptamers with improved fluorescent properties for both fixed and live-cell imaging by using competitive ligand binding microfluidic selection.

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Autores principales: Alexis Autour, Sunny C. Y. Jeng, Adam D. Cawte, Amir Abdolahzadeh, Angela Galli, Shanker S. S. Panchapakesan, David Rueda, Michael Ryckelynck, Peter J. Unrau
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/ffa23cd158524e5b94c7284e2e879efb
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