Antiviral effect of ovotransferrin in mouse peritoneal macrophages by up-regulating type I interferon expression

Ovotransferrin (OVT) is one of the major proteins in avian albumen that exerts diverse biological activities. This study is aimed to investigate the antiviral effect and mechanism of OVT from the avian egg. Effects of OVT on vesicular stomatitis virus (VSV)-infected mouse peritoneal macrophage were...

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Autores principales:	Yulan Zhou, Qun Tang, Huaying Du, Yonggang Tu, Shaofu Wu, Wenjun Wang, Mingsheng Xu
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	ovotransferrin macrophage innate immunity type i interferon antiviral effect Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ffa9c42e4bb04076a964fd52e753ec55
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spelling	oai:doaj.org-article:ffa9c42e4bb04076a964fd52e753ec552021-11-26T11:19:46ZAntiviral effect of ovotransferrin in mouse peritoneal macrophages by up-regulating type I interferon expression0954-01051465-344310.1080/09540105.2018.1424120https://doaj.org/article/ffa9c42e4bb04076a964fd52e753ec552018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2018.1424120https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443Ovotransferrin (OVT) is one of the major proteins in avian albumen that exerts diverse biological activities. This study is aimed to investigate the antiviral effect and mechanism of OVT from the avian egg. Effects of OVT on vesicular stomatitis virus (VSV)-infected mouse peritoneal macrophage were detected by real-time quantitative polymerase chain reaction, enzyme-linked immunosorbent assay, and western blot. In OVT-pretreated mouse peritoneal macrophages, results showed that replication of VSV was significantly suppressed and production of type I interferon (IFN) was increased. OVT down-regulated ring finger protein 125 (RNF125) production and up-regulated retinoic-acid-inducible gene I (RIG-I) expression by the nuclear factor-κB signalling pathway, resulting in the enhancement of the production of type I IFN. It demonstrated that the antiviral effect of OVT on innate immunity is enhanced by promoting type I IFN expression, indicating its potential as a functional food ingredient.Yulan ZhouQun TangHuaying DuYonggang TuShaofu WuWenjun WangMingsheng XuTaylor & Francis Grouparticleovotransferrinmacrophageinnate immunitytype i interferonantiviral effectAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 600-614 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	ovotransferrin macrophage innate immunity type i interferon antiviral effect Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	ovotransferrin macrophage innate immunity type i interferon antiviral effect Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Yulan Zhou Qun Tang Huaying Du Yonggang Tu Shaofu Wu Wenjun Wang Mingsheng Xu Antiviral effect of ovotransferrin in mouse peritoneal macrophages by up-regulating type I interferon expression
description	Ovotransferrin (OVT) is one of the major proteins in avian albumen that exerts diverse biological activities. This study is aimed to investigate the antiviral effect and mechanism of OVT from the avian egg. Effects of OVT on vesicular stomatitis virus (VSV)-infected mouse peritoneal macrophage were detected by real-time quantitative polymerase chain reaction, enzyme-linked immunosorbent assay, and western blot. In OVT-pretreated mouse peritoneal macrophages, results showed that replication of VSV was significantly suppressed and production of type I interferon (IFN) was increased. OVT down-regulated ring finger protein 125 (RNF125) production and up-regulated retinoic-acid-inducible gene I (RIG-I) expression by the nuclear factor-κB signalling pathway, resulting in the enhancement of the production of type I IFN. It demonstrated that the antiviral effect of OVT on innate immunity is enhanced by promoting type I IFN expression, indicating its potential as a functional food ingredient.
format	article
author	Yulan Zhou Qun Tang Huaying Du Yonggang Tu Shaofu Wu Wenjun Wang Mingsheng Xu
author_facet	Yulan Zhou Qun Tang Huaying Du Yonggang Tu Shaofu Wu Wenjun Wang Mingsheng Xu
author_sort	Yulan Zhou
title	Antiviral effect of ovotransferrin in mouse peritoneal macrophages by up-regulating type I interferon expression
title_short	Antiviral effect of ovotransferrin in mouse peritoneal macrophages by up-regulating type I interferon expression
title_full	Antiviral effect of ovotransferrin in mouse peritoneal macrophages by up-regulating type I interferon expression
title_fullStr	Antiviral effect of ovotransferrin in mouse peritoneal macrophages by up-regulating type I interferon expression
title_full_unstemmed	Antiviral effect of ovotransferrin in mouse peritoneal macrophages by up-regulating type I interferon expression
title_sort	antiviral effect of ovotransferrin in mouse peritoneal macrophages by up-regulating type i interferon expression
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/ffa9c42e4bb04076a964fd52e753ec55
work_keys_str_mv	AT yulanzhou antiviraleffectofovotransferrininmouseperitonealmacrophagesbyupregulatingtypeiinterferonexpression AT quntang antiviraleffectofovotransferrininmouseperitonealmacrophagesbyupregulatingtypeiinterferonexpression AT huayingdu antiviraleffectofovotransferrininmouseperitonealmacrophagesbyupregulatingtypeiinterferonexpression AT yonggangtu antiviraleffectofovotransferrininmouseperitonealmacrophagesbyupregulatingtypeiinterferonexpression AT shaofuwu antiviraleffectofovotransferrininmouseperitonealmacrophagesbyupregulatingtypeiinterferonexpression AT wenjunwang antiviraleffectofovotransferrininmouseperitonealmacrophagesbyupregulatingtypeiinterferonexpression AT mingshengxu antiviraleffectofovotransferrininmouseperitonealmacrophagesbyupregulatingtypeiinterferonexpression
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Antiviral effect of ovotransferrin in mouse peritoneal macrophages by up-regulating type I interferon expression

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