Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis

It is known that genotoxic stress induces high levels of ROS and deplete cellular glutathione stores. Here, Cao et al. uncover a β-catenin-dependent TCF/LEF-independent mechanism that promotes histone-mediated transcriptional activation of glutathione synthesis.

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Autores principales:	Lixue Cao, Geyan Wu, Jinrong Zhu, Zhanyao Tan, Dongni Shi, Xingui Wu, Miaoling Tang, Ziwen Li, Yameng Hu, Shuxia Zhang, Ruyuan Yu, Shuang Mo, Jueheng Wu, Erwei Song, Mengfeng Li, Libing Song, Jun Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ffab176b40414791a1654754dbf0a80b
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spelling	oai:doaj.org-article:ffab176b40414791a1654754dbf0a80b2021-12-02T14:39:42ZGenotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis10.1038/s41467-019-11696-72041-1723https://doaj.org/article/ffab176b40414791a1654754dbf0a80b2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11696-7https://doaj.org/toc/2041-1723It is known that genotoxic stress induces high levels of ROS and deplete cellular glutathione stores. Here, Cao et al. uncover a β-catenin-dependent TCF/LEF-independent mechanism that promotes histone-mediated transcriptional activation of glutathione synthesis.Lixue CaoGeyan WuJinrong ZhuZhanyao TanDongni ShiXingui WuMiaoling TangZiwen LiYameng HuShuxia ZhangRuyuan YuShuang MoJueheng WuErwei SongMengfeng LiLibing SongJun LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lixue Cao Geyan Wu Jinrong Zhu Zhanyao Tan Dongni Shi Xingui Wu Miaoling Tang Ziwen Li Yameng Hu Shuxia Zhang Ruyuan Yu Shuang Mo Jueheng Wu Erwei Song Mengfeng Li Libing Song Jun Li Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis
description	It is known that genotoxic stress induces high levels of ROS and deplete cellular glutathione stores. Here, Cao et al. uncover a β-catenin-dependent TCF/LEF-independent mechanism that promotes histone-mediated transcriptional activation of glutathione synthesis.
format	article
author	Lixue Cao Geyan Wu Jinrong Zhu Zhanyao Tan Dongni Shi Xingui Wu Miaoling Tang Ziwen Li Yameng Hu Shuxia Zhang Ruyuan Yu Shuang Mo Jueheng Wu Erwei Song Mengfeng Li Libing Song Jun Li
author_facet	Lixue Cao Geyan Wu Jinrong Zhu Zhanyao Tan Dongni Shi Xingui Wu Miaoling Tang Ziwen Li Yameng Hu Shuxia Zhang Ruyuan Yu Shuang Mo Jueheng Wu Erwei Song Mengfeng Li Libing Song Jun Li
author_sort	Lixue Cao
title	Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis
title_short	Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis
title_full	Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis
title_fullStr	Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis
title_full_unstemmed	Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis
title_sort	genotoxic stress-triggered β-catenin/jdp2/prmt5 complex facilitates reestablishing glutathione homeostasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ffab176b40414791a1654754dbf0a80b
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Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis

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