Transcription factor p73 regulates Th1 differentiation

Transcription factor p73 regulates Th1 differentiation

Heterogeneous helper T (Th) cell responses contribute to differential susceptibility to immunological disorders. Here the authors perform haplotype-based computational screens of 16 inbred mouse strains to identify a transcription factor, p73, as an important negative regulator of Th1 differentiatio...

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Autores principales: Min Ren, Majid Kazemian, Ming Zheng, JianPing He, Peng Li, Jangsuk Oh, Wei Liao, Jessica Li, Jonathan Rajaseelan, Brian L. Kelsall, Gary Peltz, Warren J. Leonard
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/ffad1db4d4b34ec79a555bbe08c7c711
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spelling oai:doaj.org-article:ffad1db4d4b34ec79a555bbe08c7c7112021-12-02T17:31:39ZTranscription factor p73 regulates Th1 differentiation10.1038/s41467-020-15172-52041-1723https://doaj.org/article/ffad1db4d4b34ec79a555bbe08c7c7112020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15172-5https://doaj.org/toc/2041-1723Heterogeneous helper T (Th) cell responses contribute to differential susceptibility to immunological disorders. Here the authors perform haplotype-based computational screens of 16 inbred mouse strains to identify a transcription factor, p73, as an important negative regulator of Th1 differentiation, with p73 deficient mice manifesting alterations in two inflammatory disease models.Min RenMajid KazemianMing ZhengJianPing HePeng LiJangsuk OhWei LiaoJessica LiJonathan RajaseelanBrian L. KelsallGary PeltzWarren J. LeonardNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Min Ren
Majid Kazemian
Ming Zheng
JianPing He
Peng Li
Jangsuk Oh
Wei Liao
Jessica Li
Jonathan Rajaseelan
Brian L. Kelsall
Gary Peltz
Warren J. Leonard
Transcription factor p73 regulates Th1 differentiation
description Heterogeneous helper T (Th) cell responses contribute to differential susceptibility to immunological disorders. Here the authors perform haplotype-based computational screens of 16 inbred mouse strains to identify a transcription factor, p73, as an important negative regulator of Th1 differentiation, with p73 deficient mice manifesting alterations in two inflammatory disease models.
format article
author Min Ren
Majid Kazemian
Ming Zheng
JianPing He
Peng Li
Jangsuk Oh
Wei Liao
Jessica Li
Jonathan Rajaseelan
Brian L. Kelsall
Gary Peltz
Warren J. Leonard
author_facet Min Ren
Majid Kazemian
Ming Zheng
JianPing He
Peng Li
Jangsuk Oh
Wei Liao
Jessica Li
Jonathan Rajaseelan
Brian L. Kelsall
Gary Peltz
Warren J. Leonard
author_sort Min Ren
title Transcription factor p73 regulates Th1 differentiation
title_short Transcription factor p73 regulates Th1 differentiation
title_full Transcription factor p73 regulates Th1 differentiation
title_fullStr Transcription factor p73 regulates Th1 differentiation
title_full_unstemmed Transcription factor p73 regulates Th1 differentiation
title_sort transcription factor p73 regulates th1 differentiation
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/ffad1db4d4b34ec79a555bbe08c7c711
work_keys_str_mv AT minren transcriptionfactorp73regulatesth1differentiation
AT majidkazemian transcriptionfactorp73regulatesth1differentiation
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AT pengli transcriptionfactorp73regulatesth1differentiation
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AT warrenjleonard transcriptionfactorp73regulatesth1differentiation
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