Synthesis of fluorapatite–hydroxyapatite nanoparticles and toxicity investigations

N Montazeri, R Jahandideh, Esmaeil BiazarDepartment of Chemistry, Islamic Azad University-Tonekabon Branch, Mazandaran, IranAbstract: In this study, calcium phosphate nanoparticles with two phases, fluorapatite (FA; Ca10(PO4)6F2) and hydroxyapatite (HA; Ca10(PO4)6(OH)2), were prepared using the sol-...

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Autores principales: N Montazeri, R Jahandideh, Esmaeil Biazar
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Publicado: Dove Medical Press 2011
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spelling oai:doaj.org-article:ffae0e9a5315472ea2631529de248d2b2021-12-02T01:31:41ZSynthesis of fluorapatite–hydroxyapatite nanoparticles and toxicity investigations1176-91141178-2013https://doaj.org/article/ffae0e9a5315472ea2631529de248d2b2011-01-01T00:00:00Zhttp://www.dovepress.com/synthesis-of-fluorapatitendashhydroxyapatite-nanoparticles-and-toxicit-a6166https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013N Montazeri, R Jahandideh, Esmaeil BiazarDepartment of Chemistry, Islamic Azad University-Tonekabon Branch, Mazandaran, IranAbstract: In this study, calcium phosphate nanoparticles with two phases, fluorapatite (FA; Ca10(PO4)6F2) and hydroxyapatite (HA; Ca10(PO4)6(OH)2), were prepared using the sol-gel method. Ethyl phosphate, hydrated calcium nitrate, and ammonium fluoride were used, respectively, as P, Ca, and F precursors with a Ca:P ratio of 1:72. Powders obtained from the sol-gel process were studied after they were dried at 80°C and heat treated at 550°C. The degree of crystallinity, particle and crystallite size, powder morphology, chemical structure, and phase analysis were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and Zetasizer experiments. The results of XRD analysis and FTIR showed the presence of hydroxyapatite and fluorapatite phases. The sizes of the crystallites estimated from XRD patterns using the Scherrer equation and the crystallinity of the hydroxyapatite phase were about 20 nm and 70%, respectively. Transmission electron microscope and SEM images and Zetasizer experiments showed an average size of 100 nm. The in vitro behavior of powder was investigated with mouse fibroblast cells. The results of these experiments indicated that the powders were biocompatibile and would not cause toxic reactions. These compounds could be applied for hard-tissue engineering.Keywords: fluorapatite, hydroxyapatite, sol-gel, nanoparticles, biocompatibility N MontazeriR JahandidehEsmaeil BiazarDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 197-201 (2011)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
N Montazeri
R Jahandideh
Esmaeil Biazar
Synthesis of fluorapatite–hydroxyapatite nanoparticles and toxicity investigations
description N Montazeri, R Jahandideh, Esmaeil BiazarDepartment of Chemistry, Islamic Azad University-Tonekabon Branch, Mazandaran, IranAbstract: In this study, calcium phosphate nanoparticles with two phases, fluorapatite (FA; Ca10(PO4)6F2) and hydroxyapatite (HA; Ca10(PO4)6(OH)2), were prepared using the sol-gel method. Ethyl phosphate, hydrated calcium nitrate, and ammonium fluoride were used, respectively, as P, Ca, and F precursors with a Ca:P ratio of 1:72. Powders obtained from the sol-gel process were studied after they were dried at 80°C and heat treated at 550°C. The degree of crystallinity, particle and crystallite size, powder morphology, chemical structure, and phase analysis were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and Zetasizer experiments. The results of XRD analysis and FTIR showed the presence of hydroxyapatite and fluorapatite phases. The sizes of the crystallites estimated from XRD patterns using the Scherrer equation and the crystallinity of the hydroxyapatite phase were about 20 nm and 70%, respectively. Transmission electron microscope and SEM images and Zetasizer experiments showed an average size of 100 nm. The in vitro behavior of powder was investigated with mouse fibroblast cells. The results of these experiments indicated that the powders were biocompatibile and would not cause toxic reactions. These compounds could be applied for hard-tissue engineering.Keywords: fluorapatite, hydroxyapatite, sol-gel, nanoparticles, biocompatibility
format article
author N Montazeri
R Jahandideh
Esmaeil Biazar
author_facet N Montazeri
R Jahandideh
Esmaeil Biazar
author_sort N Montazeri
title Synthesis of fluorapatite–hydroxyapatite nanoparticles and toxicity investigations
title_short Synthesis of fluorapatite–hydroxyapatite nanoparticles and toxicity investigations
title_full Synthesis of fluorapatite–hydroxyapatite nanoparticles and toxicity investigations
title_fullStr Synthesis of fluorapatite–hydroxyapatite nanoparticles and toxicity investigations
title_full_unstemmed Synthesis of fluorapatite–hydroxyapatite nanoparticles and toxicity investigations
title_sort synthesis of fluorapatite–hydroxyapatite nanoparticles and toxicity investigations
publisher Dove Medical Press
publishDate 2011
url https://doaj.org/article/ffae0e9a5315472ea2631529de248d2b
work_keys_str_mv AT nmontazeri synthesisoffluorapatiteampndashhydroxyapatitenanoparticlesandtoxicityinvestigations
AT rjahandideh synthesisoffluorapatiteampndashhydroxyapatitenanoparticlesandtoxicityinvestigations
AT esmaeilbiazar synthesisoffluorapatiteampndashhydroxyapatitenanoparticlesandtoxicityinvestigations
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