Proliferative vitreoretinopathy: current and emerging treatments
Ama Sadaka,1 Gian Paolo Giuliari2,31Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; 2Centro de Cirugía Oftalmológica (CECOF), Caracas, Venezuela; 3Department of Ophthalmology, Domingo Luciani Hospital, Caracas, VenezuelaAbstract: Proli...
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Dove Medical Press
2012
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oai:doaj.org-article:ffb1521046dc4168b8e094ef699c09a02021-12-02T00:33:14ZProliferative vitreoretinopathy: current and emerging treatments1177-54671177-5483https://doaj.org/article/ffb1521046dc4168b8e094ef699c09a02012-08-01T00:00:00Zhttp://www.dovepress.com/proliferative-vitreoretinopathy-current-and-emerging-treatments-a10693https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Ama Sadaka,1 Gian Paolo Giuliari2,31Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; 2Centro de Cirugía Oftalmológica (CECOF), Caracas, Venezuela; 3Department of Ophthalmology, Domingo Luciani Hospital, Caracas, VenezuelaAbstract: Proliferative vitreoretinopathy is a disease process that follows the proliferation of ectopic cell sheets in the vitreous and/or periretinal area, causing periretinal membrane formation and traction, in patients with rhegmatogenous retinal detachments. Currently, vitreous surgery is the standard treatment; however, the results aren't satisfactory given the vision loss that ensues and that redetachment is relatively common. It is becoming clearer that there exists an interplay between various cytokines/growth factors, matrix proteins, and the different cell types that drive the undesirable formation of periretinal membranes. This fundamental understanding is aiding in identifying different adjunct agents that can block the cellular events intrinsic to proliferative vitreoretinopathy. In this review, we describe the current understanding on the pathogenesis and discuss how the fundamental understanding of the biochemical/molecular events is instrumental in developing the novel treatment strategies that are also highlighted.Keywords: proliferative vitreoretinopathy, retinal detachment, vision lossSadaka AGiuliari GPDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 1325-1333 (2012) |
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Ophthalmology RE1-994 |
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Ophthalmology RE1-994 Sadaka A Giuliari GP Proliferative vitreoretinopathy: current and emerging treatments |
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Ama Sadaka,1 Gian Paolo Giuliari2,31Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; 2Centro de Cirugía Oftalmológica (CECOF), Caracas, Venezuela; 3Department of Ophthalmology, Domingo Luciani Hospital, Caracas, VenezuelaAbstract: Proliferative vitreoretinopathy is a disease process that follows the proliferation of ectopic cell sheets in the vitreous and/or periretinal area, causing periretinal membrane formation and traction, in patients with rhegmatogenous retinal detachments. Currently, vitreous surgery is the standard treatment; however, the results aren't satisfactory given the vision loss that ensues and that redetachment is relatively common. It is becoming clearer that there exists an interplay between various cytokines/growth factors, matrix proteins, and the different cell types that drive the undesirable formation of periretinal membranes. This fundamental understanding is aiding in identifying different adjunct agents that can block the cellular events intrinsic to proliferative vitreoretinopathy. In this review, we describe the current understanding on the pathogenesis and discuss how the fundamental understanding of the biochemical/molecular events is instrumental in developing the novel treatment strategies that are also highlighted.Keywords: proliferative vitreoretinopathy, retinal detachment, vision loss |
format |
article |
author |
Sadaka A Giuliari GP |
author_facet |
Sadaka A Giuliari GP |
author_sort |
Sadaka A |
title |
Proliferative vitreoretinopathy: current and emerging treatments |
title_short |
Proliferative vitreoretinopathy: current and emerging treatments |
title_full |
Proliferative vitreoretinopathy: current and emerging treatments |
title_fullStr |
Proliferative vitreoretinopathy: current and emerging treatments |
title_full_unstemmed |
Proliferative vitreoretinopathy: current and emerging treatments |
title_sort |
proliferative vitreoretinopathy: current and emerging treatments |
publisher |
Dove Medical Press |
publishDate |
2012 |
url |
https://doaj.org/article/ffb1521046dc4168b8e094ef699c09a0 |
work_keys_str_mv |
AT sadakaa proliferativevitreoretinopathycurrentandemergingtreatments AT giuliarigp proliferativevitreoretinopathycurrentandemergingtreatments |
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1718403717722537984 |