Proliferative vitreoretinopathy: current and emerging treatments

Ama Sadaka,1 Gian Paolo Giuliari2,31Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; 2Centro de Cirugía Oftalmológica (CECOF), Caracas, Venezuela; 3Department of Ophthalmology, Domingo Luciani Hospital, Caracas, VenezuelaAbstract: Proli...

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Autores principales: Sadaka A, Giuliari GP
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Publicado: Dove Medical Press 2012
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spelling oai:doaj.org-article:ffb1521046dc4168b8e094ef699c09a02021-12-02T00:33:14ZProliferative vitreoretinopathy: current and emerging treatments1177-54671177-5483https://doaj.org/article/ffb1521046dc4168b8e094ef699c09a02012-08-01T00:00:00Zhttp://www.dovepress.com/proliferative-vitreoretinopathy-current-and-emerging-treatments-a10693https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Ama Sadaka,1 Gian Paolo Giuliari2,31Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; 2Centro de Cirugía Oftalmológica (CECOF), Caracas, Venezuela; 3Department of Ophthalmology, Domingo Luciani Hospital, Caracas, VenezuelaAbstract: Proliferative vitreoretinopathy is a disease process that follows the proliferation of ectopic cell sheets in the vitreous and/or periretinal area, causing periretinal membrane formation and traction, in patients with rhegmatogenous retinal detachments. Currently, vitreous surgery is the standard treatment; however, the results aren't satisfactory given the vision loss that ensues and that redetachment is relatively common. It is becoming clearer that there exists an interplay between various cytokines/growth factors, matrix proteins, and the different cell types that drive the undesirable formation of periretinal membranes. This fundamental understanding is aiding in identifying different adjunct agents that can block the cellular events intrinsic to proliferative vitreoretinopathy. In this review, we describe the current understanding on the pathogenesis and discuss how the fundamental understanding of the biochemical/molecular events is instrumental in developing the novel treatment strategies that are also highlighted.Keywords: proliferative vitreoretinopathy, retinal detachment, vision lossSadaka AGiuliari GPDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 1325-1333 (2012)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Sadaka A
Giuliari GP
Proliferative vitreoretinopathy: current and emerging treatments
description Ama Sadaka,1 Gian Paolo Giuliari2,31Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; 2Centro de Cirugía Oftalmológica (CECOF), Caracas, Venezuela; 3Department of Ophthalmology, Domingo Luciani Hospital, Caracas, VenezuelaAbstract: Proliferative vitreoretinopathy is a disease process that follows the proliferation of ectopic cell sheets in the vitreous and/or periretinal area, causing periretinal membrane formation and traction, in patients with rhegmatogenous retinal detachments. Currently, vitreous surgery is the standard treatment; however, the results aren't satisfactory given the vision loss that ensues and that redetachment is relatively common. It is becoming clearer that there exists an interplay between various cytokines/growth factors, matrix proteins, and the different cell types that drive the undesirable formation of periretinal membranes. This fundamental understanding is aiding in identifying different adjunct agents that can block the cellular events intrinsic to proliferative vitreoretinopathy. In this review, we describe the current understanding on the pathogenesis and discuss how the fundamental understanding of the biochemical/molecular events is instrumental in developing the novel treatment strategies that are also highlighted.Keywords: proliferative vitreoretinopathy, retinal detachment, vision loss
format article
author Sadaka A
Giuliari GP
author_facet Sadaka A
Giuliari GP
author_sort Sadaka A
title Proliferative vitreoretinopathy: current and emerging treatments
title_short Proliferative vitreoretinopathy: current and emerging treatments
title_full Proliferative vitreoretinopathy: current and emerging treatments
title_fullStr Proliferative vitreoretinopathy: current and emerging treatments
title_full_unstemmed Proliferative vitreoretinopathy: current and emerging treatments
title_sort proliferative vitreoretinopathy: current and emerging treatments
publisher Dove Medical Press
publishDate 2012
url https://doaj.org/article/ffb1521046dc4168b8e094ef699c09a0
work_keys_str_mv AT sadakaa proliferativevitreoretinopathycurrentandemergingtreatments
AT giuliarigp proliferativevitreoretinopathycurrentandemergingtreatments
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