Long noncoding RNA CCAT1 rs67085638 SNP contribution to the progression of gastric cancer in a Polish population

Abstract The role of the long noncoding RNA CCAT1 NC_000008.10:g.128220661C > T (rs67085638) in the development of colon cancer has been reported. Therefore, we assessed the prevalence of rs67085638 in patients with gastric cancer (GC). We also evaluated the effect of rs67085638 on B-cell-specifi...

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Autores principales:	Tomasz Olesiński, Anna Lutkowska, Adam Balcerek, Anna Sowińska, P Piotrowski, Tomasz Trzeciak, Tomasz Maj, Piotr Hevelke, Pawel P. Jagodziński
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ffb5ae3deb654efa87b4414543541935
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spelling	oai:doaj.org-article:ffb5ae3deb654efa87b44145435419352021-12-02T16:06:42ZLong noncoding RNA CCAT1 rs67085638 SNP contribution to the progression of gastric cancer in a Polish population10.1038/s41598-021-94576-92045-2322https://doaj.org/article/ffb5ae3deb654efa87b44145435419352021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94576-9https://doaj.org/toc/2045-2322Abstract The role of the long noncoding RNA CCAT1 NC_000008.10:g.128220661C > T (rs67085638) in the development of colon cancer has been reported. Therefore, we assessed the prevalence of rs67085638 in patients with gastric cancer (GC). We also evaluated the effect of rs67085638 on B-cell-specific Moloney leukaemia virus insertion site 1 (BMI1) transcripts in primary GC and counterpart histopathologically confirmed disease-free margin tissue. Using high-resolution melting analysis, we evaluated rs67085638 frequency in patients with the GC genotype (n = 214) and controls (n = 502) in a Polish Caucasian population. qRT-PCR was used to determine BMI1 transcripts. We observed the trend of rs67085638 association in all patients with GC (p trend = 0.028), a strong risk of the GC genotype in male (p trend = 0.035) but not female (p trend = 0.747) patients, and the association with non-cardia GC (p trend = 0.041), tumour stages T3 (p trend = 0.014) and T4 (p trend = 0.032), differentiation grading G3 (p trend = 0.009), lymph node metastasis stage N3 (p trend = 0.0005) and metastasis stage M0 (p trend = 0.027). We found that significantly increased BMI1 transcripts were associated with the primary GC genotype classified as grade G3 (p = 0.011) and as lymph node metastasis N3 (p = 0.010) and counterpart marginal tissues (p = 0.026, p = 0.040, respectively) from carriers of the T/T versus C/C genotypes. rs67085638 may contribute to increased BMI1 transcripts and the progression and rapid growth of GC.Tomasz OlesińskiAnna LutkowskaAdam BalcerekAnna SowińskaP PiotrowskiTomasz TrzeciakTomasz MajPiotr HevelkePawel P. JagodzińskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomasz Olesiński Anna Lutkowska Adam Balcerek Anna Sowińska P Piotrowski Tomasz Trzeciak Tomasz Maj Piotr Hevelke Pawel P. Jagodziński Long noncoding RNA CCAT1 rs67085638 SNP contribution to the progression of gastric cancer in a Polish population
description	Abstract The role of the long noncoding RNA CCAT1 NC_000008.10:g.128220661C > T (rs67085638) in the development of colon cancer has been reported. Therefore, we assessed the prevalence of rs67085638 in patients with gastric cancer (GC). We also evaluated the effect of rs67085638 on B-cell-specific Moloney leukaemia virus insertion site 1 (BMI1) transcripts in primary GC and counterpart histopathologically confirmed disease-free margin tissue. Using high-resolution melting analysis, we evaluated rs67085638 frequency in patients with the GC genotype (n = 214) and controls (n = 502) in a Polish Caucasian population. qRT-PCR was used to determine BMI1 transcripts. We observed the trend of rs67085638 association in all patients with GC (p trend = 0.028), a strong risk of the GC genotype in male (p trend = 0.035) but not female (p trend = 0.747) patients, and the association with non-cardia GC (p trend = 0.041), tumour stages T3 (p trend = 0.014) and T4 (p trend = 0.032), differentiation grading G3 (p trend = 0.009), lymph node metastasis stage N3 (p trend = 0.0005) and metastasis stage M0 (p trend = 0.027). We found that significantly increased BMI1 transcripts were associated with the primary GC genotype classified as grade G3 (p = 0.011) and as lymph node metastasis N3 (p = 0.010) and counterpart marginal tissues (p = 0.026, p = 0.040, respectively) from carriers of the T/T versus C/C genotypes. rs67085638 may contribute to increased BMI1 transcripts and the progression and rapid growth of GC.
format	article
author	Tomasz Olesiński Anna Lutkowska Adam Balcerek Anna Sowińska P Piotrowski Tomasz Trzeciak Tomasz Maj Piotr Hevelke Pawel P. Jagodziński
author_facet	Tomasz Olesiński Anna Lutkowska Adam Balcerek Anna Sowińska P Piotrowski Tomasz Trzeciak Tomasz Maj Piotr Hevelke Pawel P. Jagodziński
author_sort	Tomasz Olesiński
title	Long noncoding RNA CCAT1 rs67085638 SNP contribution to the progression of gastric cancer in a Polish population
title_short	Long noncoding RNA CCAT1 rs67085638 SNP contribution to the progression of gastric cancer in a Polish population
title_full	Long noncoding RNA CCAT1 rs67085638 SNP contribution to the progression of gastric cancer in a Polish population
title_fullStr	Long noncoding RNA CCAT1 rs67085638 SNP contribution to the progression of gastric cancer in a Polish population
title_full_unstemmed	Long noncoding RNA CCAT1 rs67085638 SNP contribution to the progression of gastric cancer in a Polish population
title_sort	long noncoding rna ccat1 rs67085638 snp contribution to the progression of gastric cancer in a polish population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ffb5ae3deb654efa87b4414543541935
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Long noncoding RNA CCAT1 rs67085638 SNP contribution to the progression of gastric cancer in a Polish population

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