APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling

The exonuclease Apurinic/apyrimidinic endonuclease 1 (APE1) is important for processing matched/mismatched terminus during DNA repair. Here the authors resolve the X-ray crystallography structures of APE1 with varied dsDNAs substrates to assay the nuclease activity.

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Autores principales:	Tung-Chang Liu, Chun-Ting Lin, Kai-Cheng Chang, Kai-Wei Guo, Shuying Wang, Jhih-Wei Chu, Yu-Yuan Hsiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ffb6ab14e7a9497fa2f390f15e2f2fc4
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spelling	oai:doaj.org-article:ffb6ab14e7a9497fa2f390f15e2f2fc42021-12-02T10:48:27ZAPE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling10.1038/s41467-020-20853-22041-1723https://doaj.org/article/ffb6ab14e7a9497fa2f390f15e2f2fc42021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20853-2https://doaj.org/toc/2041-1723The exonuclease Apurinic/apyrimidinic endonuclease 1 (APE1) is important for processing matched/mismatched terminus during DNA repair. Here the authors resolve the X-ray crystallography structures of APE1 with varied dsDNAs substrates to assay the nuclease activity.Tung-Chang LiuChun-Ting LinKai-Cheng ChangKai-Wei GuoShuying WangJhih-Wei ChuYu-Yuan HsiaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tung-Chang Liu Chun-Ting Lin Kai-Cheng Chang Kai-Wei Guo Shuying Wang Jhih-Wei Chu Yu-Yuan Hsiao APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling
description	The exonuclease Apurinic/apyrimidinic endonuclease 1 (APE1) is important for processing matched/mismatched terminus during DNA repair. Here the authors resolve the X-ray crystallography structures of APE1 with varied dsDNAs substrates to assay the nuclease activity.
format	article
author	Tung-Chang Liu Chun-Ting Lin Kai-Cheng Chang Kai-Wei Guo Shuying Wang Jhih-Wei Chu Yu-Yuan Hsiao
author_facet	Tung-Chang Liu Chun-Ting Lin Kai-Cheng Chang Kai-Wei Guo Shuying Wang Jhih-Wei Chu Yu-Yuan Hsiao
author_sort	Tung-Chang Liu
title	APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling
title_short	APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling
title_full	APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling
title_fullStr	APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling
title_full_unstemmed	APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling
title_sort	ape1 distinguishes dna substrates in exonucleolytic cleavage by induced space-filling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ffb6ab14e7a9497fa2f390f15e2f2fc4
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APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling

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