Proportions of Polyunsaturated Fatty Acids in Umbilical Cord Blood at Birth Are Related to Atopic Eczema Development in the First Year of Life

Atopic eczema, the most common atopic disease in infants, may pave the way for sensitization and allergy later in childhood. Fatty acids have immune-regulating properties and may regulate skin permeability. Here we examine whether the proportions of fatty acids among the infant and maternal plasma p...

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Autores principales:	Malin Barman, Mia Stråvik, Karin Broberg, Anna Sandin, Agnes E. Wold, Ann-Sofie Sandberg
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diet pregnancy cord blood fatty acids n-3 PUFAs n-6 PUFAs Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/ffb70db1e08a4d7da52921c3d71aaeed
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spelling	oai:doaj.org-article:ffb70db1e08a4d7da52921c3d71aaeed2021-11-25T18:33:57ZProportions of Polyunsaturated Fatty Acids in Umbilical Cord Blood at Birth Are Related to Atopic Eczema Development in the First Year of Life10.3390/nu131137792072-6643https://doaj.org/article/ffb70db1e08a4d7da52921c3d71aaeed2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3779https://doaj.org/toc/2072-6643Atopic eczema, the most common atopic disease in infants, may pave the way for sensitization and allergy later in childhood. Fatty acids have immune-regulating properties and may regulate skin permeability. Here we examine whether the proportions of fatty acids among the infant and maternal plasma phospholipids at birth were associated with maternal dietary intake during pregnancy and development of atopic eczema during the first year of age in the Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE) birth cohort. Dietary data were collected with a semi-quantitative food frequency questionnaire, fatty acids were measured with GC-MS and atopic eczema was diagnosed by a pediatric allergologist at 12 months of age. We found that higher proportions of n-6 PUFAs (including arachidonic acid) but lower proportions of n-3 PUFAs (including DPA) in the infant’s phospholipids at birth were associated with an increased risk of atopic eczema at 12 months of age. The n-6 and n-3 PUFAs were related to maternal intake of meat and fish, respectively. Our results suggest that prenatal exposure to unsaturated fatty acids is associated with eczema development in the infant. Maternal diet during pregnancy may partly explain the fatty acid profiles <i>in utero</i>.Malin BarmanMia StråvikKarin BrobergAnna SandinAgnes E. WoldAnn-Sofie SandbergMDPI AGarticledietpregnancycord bloodfatty acidsn-3 PUFAsn-6 PUFAsNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3779, p 3779 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diet pregnancy cord blood fatty acids n-3 PUFAs n-6 PUFAs Nutrition. Foods and food supply TX341-641
spellingShingle	diet pregnancy cord blood fatty acids n-3 PUFAs n-6 PUFAs Nutrition. Foods and food supply TX341-641 Malin Barman Mia Stråvik Karin Broberg Anna Sandin Agnes E. Wold Ann-Sofie Sandberg Proportions of Polyunsaturated Fatty Acids in Umbilical Cord Blood at Birth Are Related to Atopic Eczema Development in the First Year of Life
description	Atopic eczema, the most common atopic disease in infants, may pave the way for sensitization and allergy later in childhood. Fatty acids have immune-regulating properties and may regulate skin permeability. Here we examine whether the proportions of fatty acids among the infant and maternal plasma phospholipids at birth were associated with maternal dietary intake during pregnancy and development of atopic eczema during the first year of age in the Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE) birth cohort. Dietary data were collected with a semi-quantitative food frequency questionnaire, fatty acids were measured with GC-MS and atopic eczema was diagnosed by a pediatric allergologist at 12 months of age. We found that higher proportions of n-6 PUFAs (including arachidonic acid) but lower proportions of n-3 PUFAs (including DPA) in the infant’s phospholipids at birth were associated with an increased risk of atopic eczema at 12 months of age. The n-6 and n-3 PUFAs were related to maternal intake of meat and fish, respectively. Our results suggest that prenatal exposure to unsaturated fatty acids is associated with eczema development in the infant. Maternal diet during pregnancy may partly explain the fatty acid profiles <i>in utero</i>.
format	article
author	Malin Barman Mia Stråvik Karin Broberg Anna Sandin Agnes E. Wold Ann-Sofie Sandberg
author_facet	Malin Barman Mia Stråvik Karin Broberg Anna Sandin Agnes E. Wold Ann-Sofie Sandberg
author_sort	Malin Barman
title	Proportions of Polyunsaturated Fatty Acids in Umbilical Cord Blood at Birth Are Related to Atopic Eczema Development in the First Year of Life
title_short	Proportions of Polyunsaturated Fatty Acids in Umbilical Cord Blood at Birth Are Related to Atopic Eczema Development in the First Year of Life
title_full	Proportions of Polyunsaturated Fatty Acids in Umbilical Cord Blood at Birth Are Related to Atopic Eczema Development in the First Year of Life
title_fullStr	Proportions of Polyunsaturated Fatty Acids in Umbilical Cord Blood at Birth Are Related to Atopic Eczema Development in the First Year of Life
title_full_unstemmed	Proportions of Polyunsaturated Fatty Acids in Umbilical Cord Blood at Birth Are Related to Atopic Eczema Development in the First Year of Life
title_sort	proportions of polyunsaturated fatty acids in umbilical cord blood at birth are related to atopic eczema development in the first year of life
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ffb70db1e08a4d7da52921c3d71aaeed
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Proportions of Polyunsaturated Fatty Acids in Umbilical Cord Blood at Birth Are Related to Atopic Eczema Development in the First Year of Life

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