Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism

Abstract Case–control genetic association studies typically ignore possible later disease onset in currently healthy subjects and assume that subjects with diseases equally contribute to the likelihood for inference, regardless of their onset age. Therefore, we used an event-history with risk-free m...

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Autores principales:	Hsin-Chou Yang, I-Chen Chen, Yuh-Chyuan Tsay, Zheng-Rong Li, Chun-houh Chen, Hai-Gwo Hwu, Chen-Hsin Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ffb735eff1554d69bcc98465e32abdab
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spelling	oai:doaj.org-article:ffb735eff1554d69bcc98465e32abdab2021-12-02T16:06:13ZUsing an Event-History with Risk-Free Model to Study the Genetics of Alcoholism10.1038/s41598-017-01791-42045-2322https://doaj.org/article/ffb735eff1554d69bcc98465e32abdab2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01791-4https://doaj.org/toc/2045-2322Abstract Case–control genetic association studies typically ignore possible later disease onset in currently healthy subjects and assume that subjects with diseases equally contribute to the likelihood for inference, regardless of their onset age. Therefore, we used an event-history with risk-free model to simultaneously characterize alcoholism susceptibility and onset age in 65 independent non-Hispanic Caucasian males in the Collaborative Study on the Genetics of Alcoholism. Following data quality control, we analysed 22 single nucleotide polymorphisms (SNPs) on 12 candidate genes. The single-SNP analysis showed that the dominant minor allele of rs2134655 on DRD3 increases alcoholism susceptibility; the dominant minor allele of rs1439047 on NTRK2 delays the alcoholism onset age, but the additive minor allele of rs172677 on GRIN2B and the dominant minor allele of rs63319 on ALDH1A1 advance the alcoholism onset age; and the dominant minor allele of rs1079597 on DRD2 shortens the onset age range. Similarly, multiple-SNPs analysis revealed joint effects of rs2134655, rs172677 and rs1079597, with an adjustment for habitual smoking. This study provides a more comprehensive understanding of the genetics of alcoholism than previous case–control studies.Hsin-Chou YangI-Chen ChenYuh-Chyuan TsayZheng-Rong LiChun-houh ChenHai-Gwo HwuChen-Hsin ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hsin-Chou Yang I-Chen Chen Yuh-Chyuan Tsay Zheng-Rong Li Chun-houh Chen Hai-Gwo Hwu Chen-Hsin Chen Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism
description	Abstract Case–control genetic association studies typically ignore possible later disease onset in currently healthy subjects and assume that subjects with diseases equally contribute to the likelihood for inference, regardless of their onset age. Therefore, we used an event-history with risk-free model to simultaneously characterize alcoholism susceptibility and onset age in 65 independent non-Hispanic Caucasian males in the Collaborative Study on the Genetics of Alcoholism. Following data quality control, we analysed 22 single nucleotide polymorphisms (SNPs) on 12 candidate genes. The single-SNP analysis showed that the dominant minor allele of rs2134655 on DRD3 increases alcoholism susceptibility; the dominant minor allele of rs1439047 on NTRK2 delays the alcoholism onset age, but the additive minor allele of rs172677 on GRIN2B and the dominant minor allele of rs63319 on ALDH1A1 advance the alcoholism onset age; and the dominant minor allele of rs1079597 on DRD2 shortens the onset age range. Similarly, multiple-SNPs analysis revealed joint effects of rs2134655, rs172677 and rs1079597, with an adjustment for habitual smoking. This study provides a more comprehensive understanding of the genetics of alcoholism than previous case–control studies.
format	article
author	Hsin-Chou Yang I-Chen Chen Yuh-Chyuan Tsay Zheng-Rong Li Chun-houh Chen Hai-Gwo Hwu Chen-Hsin Chen
author_facet	Hsin-Chou Yang I-Chen Chen Yuh-Chyuan Tsay Zheng-Rong Li Chun-houh Chen Hai-Gwo Hwu Chen-Hsin Chen
author_sort	Hsin-Chou Yang
title	Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism
title_short	Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism
title_full	Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism
title_fullStr	Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism
title_full_unstemmed	Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism
title_sort	using an event-history with risk-free model to study the genetics of alcoholism
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ffb735eff1554d69bcc98465e32abdab
work_keys_str_mv	AT hsinchouyang usinganeventhistorywithriskfreemodeltostudythegeneticsofalcoholism AT ichenchen usinganeventhistorywithriskfreemodeltostudythegeneticsofalcoholism AT yuhchyuantsay usinganeventhistorywithriskfreemodeltostudythegeneticsofalcoholism AT zhengrongli usinganeventhistorywithriskfreemodeltostudythegeneticsofalcoholism AT chunhouhchen usinganeventhistorywithriskfreemodeltostudythegeneticsofalcoholism AT haigwohwu usinganeventhistorywithriskfreemodeltostudythegeneticsofalcoholism AT chenhsinchen usinganeventhistorywithriskfreemodeltostudythegeneticsofalcoholism
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Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism

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