Complete loss of H3K9 methylation dissolves mouse heterochromatin organization

Histone H3K9 methylation (H3K9me) states define repressed chromatin in eukaryotic cells. Here the authors reveal complete loss of all H3K9me in mammalian cells through successive deletion of H3K9 methyltransferase genes that results in the dissolution of heterochromatin and the derepression of nearl...

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Autores principales:	Thomas Montavon, Nicholas Shukeir, Galina Erikson, Bettina Engist, Megumi Onishi-Seebacher, Devon Ryan, Yaarub Musa, Gerhard Mittler, Alexandra Graff Meyer, Christel Genoud, Thomas Jenuwein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ffb762bd6b22494b91032351da989456
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spelling	oai:doaj.org-article:ffb762bd6b22494b91032351da9894562021-12-02T17:01:14ZComplete loss of H3K9 methylation dissolves mouse heterochromatin organization10.1038/s41467-021-24532-82041-1723https://doaj.org/article/ffb762bd6b22494b91032351da9894562021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24532-8https://doaj.org/toc/2041-1723Histone H3K9 methylation (H3K9me) states define repressed chromatin in eukaryotic cells. Here the authors reveal complete loss of all H3K9me in mammalian cells through successive deletion of H3K9 methyltransferase genes that results in the dissolution of heterochromatin and the derepression of nearly all repeat families.Thomas MontavonNicholas ShukeirGalina EriksonBettina EngistMegumi Onishi-SeebacherDevon RyanYaarub MusaGerhard MittlerAlexandra Graff MeyerChristel GenoudThomas JenuweinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas Montavon Nicholas Shukeir Galina Erikson Bettina Engist Megumi Onishi-Seebacher Devon Ryan Yaarub Musa Gerhard Mittler Alexandra Graff Meyer Christel Genoud Thomas Jenuwein Complete loss of H3K9 methylation dissolves mouse heterochromatin organization
description	Histone H3K9 methylation (H3K9me) states define repressed chromatin in eukaryotic cells. Here the authors reveal complete loss of all H3K9me in mammalian cells through successive deletion of H3K9 methyltransferase genes that results in the dissolution of heterochromatin and the derepression of nearly all repeat families.
format	article
author	Thomas Montavon Nicholas Shukeir Galina Erikson Bettina Engist Megumi Onishi-Seebacher Devon Ryan Yaarub Musa Gerhard Mittler Alexandra Graff Meyer Christel Genoud Thomas Jenuwein
author_facet	Thomas Montavon Nicholas Shukeir Galina Erikson Bettina Engist Megumi Onishi-Seebacher Devon Ryan Yaarub Musa Gerhard Mittler Alexandra Graff Meyer Christel Genoud Thomas Jenuwein
author_sort	Thomas Montavon
title	Complete loss of H3K9 methylation dissolves mouse heterochromatin organization
title_short	Complete loss of H3K9 methylation dissolves mouse heterochromatin organization
title_full	Complete loss of H3K9 methylation dissolves mouse heterochromatin organization
title_fullStr	Complete loss of H3K9 methylation dissolves mouse heterochromatin organization
title_full_unstemmed	Complete loss of H3K9 methylation dissolves mouse heterochromatin organization
title_sort	complete loss of h3k9 methylation dissolves mouse heterochromatin organization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ffb762bd6b22494b91032351da989456
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Complete loss of H3K9 methylation dissolves mouse heterochromatin organization

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