Complete loss of H3K9 methylation dissolves mouse heterochromatin organization

Complete loss of H3K9 methylation dissolves mouse heterochromatin organization

Histone H3K9 methylation (H3K9me) states define repressed chromatin in eukaryotic cells. Here the authors reveal complete loss of all H3K9me in mammalian cells through successive deletion of H3K9 methyltransferase genes that results in the dissolution of heterochromatin and the derepression of nearl...

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Autores principales: Thomas Montavon, Nicholas Shukeir, Galina Erikson, Bettina Engist, Megumi Onishi-Seebacher, Devon Ryan, Yaarub Musa, Gerhard Mittler, Alexandra Graff Meyer, Christel Genoud, Thomas Jenuwein
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ffb762bd6b22494b91032351da989456
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