DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer

Immunotherapy often fails as a single option treatment in cancer. Here, the authors show that targeting of DNA methyltransferases, such as DNMT1, can potentiate anti-tumor immunity and response to checkpoint inhibition by increasing MHC gene expression and the recruitment of CD8+ T cells.

Guardado en:

Detalles Bibliográficos
Autores principales:	Na Luo, Mellissa J. Nixon, Paula I. Gonzalez-Ericsson, Violeta Sanchez, Susan R. Opalenik, Huili Li, Cynthia A. Zahnow, Michael L. Nickels, Fei Liu, Mohammed N. Tantawy, Melinda E. Sanders, H. Charles Manning, Justin M. Balko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ffb91a393be74576a78dffc6f8e78041
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ffb91a393be74576a78dffc6f8e78041
record_format	dspace
spelling	oai:doaj.org-article:ffb91a393be74576a78dffc6f8e780412021-12-02T17:31:29ZDNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer10.1038/s41467-017-02630-w2041-1723https://doaj.org/article/ffb91a393be74576a78dffc6f8e780412018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02630-whttps://doaj.org/toc/2041-1723Immunotherapy often fails as a single option treatment in cancer. Here, the authors show that targeting of DNA methyltransferases, such as DNMT1, can potentiate anti-tumor immunity and response to checkpoint inhibition by increasing MHC gene expression and the recruitment of CD8+ T cells.Na LuoMellissa J. NixonPaula I. Gonzalez-EricssonVioleta SanchezSusan R. OpalenikHuili LiCynthia A. ZahnowMichael L. NickelsFei LiuMohammed N. TantawyMelinda E. SandersH. Charles ManningJustin M. BalkoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Na Luo Mellissa J. Nixon Paula I. Gonzalez-Ericsson Violeta Sanchez Susan R. Opalenik Huili Li Cynthia A. Zahnow Michael L. Nickels Fei Liu Mohammed N. Tantawy Melinda E. Sanders H. Charles Manning Justin M. Balko DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer
description	Immunotherapy often fails as a single option treatment in cancer. Here, the authors show that targeting of DNA methyltransferases, such as DNMT1, can potentiate anti-tumor immunity and response to checkpoint inhibition by increasing MHC gene expression and the recruitment of CD8+ T cells.
format	article
author	Na Luo Mellissa J. Nixon Paula I. Gonzalez-Ericsson Violeta Sanchez Susan R. Opalenik Huili Li Cynthia A. Zahnow Michael L. Nickels Fei Liu Mohammed N. Tantawy Melinda E. Sanders H. Charles Manning Justin M. Balko
author_facet	Na Luo Mellissa J. Nixon Paula I. Gonzalez-Ericsson Violeta Sanchez Susan R. Opalenik Huili Li Cynthia A. Zahnow Michael L. Nickels Fei Liu Mohammed N. Tantawy Melinda E. Sanders H. Charles Manning Justin M. Balko
author_sort	Na Luo
title	DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer
title_short	DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer
title_full	DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer
title_fullStr	DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer
title_full_unstemmed	DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer
title_sort	dna methyltransferase inhibition upregulates mhc-i to potentiate cytotoxic t lymphocyte responses in breast cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ffb91a393be74576a78dffc6f8e78041
work_keys_str_mv	AT naluo dnamethyltransferaseinhibitionupregulatesmhcitopotentiatecytotoxictlymphocyteresponsesinbreastcancer AT mellissajnixon dnamethyltransferaseinhibitionupregulatesmhcitopotentiatecytotoxictlymphocyteresponsesinbreastcancer AT paulaigonzalezericsson dnamethyltransferaseinhibitionupregulatesmhcitopotentiatecytotoxictlymphocyteresponsesinbreastcancer AT violetasanchez dnamethyltransferaseinhibitionupregulatesmhcitopotentiatecytotoxictlymphocyteresponsesinbreastcancer AT susanropalenik dnamethyltransferaseinhibitionupregulatesmhcitopotentiatecytotoxictlymphocyteresponsesinbreastcancer AT huilili dnamethyltransferaseinhibitionupregulatesmhcitopotentiatecytotoxictlymphocyteresponsesinbreastcancer AT cynthiaazahnow dnamethyltransferaseinhibitionupregulatesmhcitopotentiatecytotoxictlymphocyteresponsesinbreastcancer AT michaellnickels dnamethyltransferaseinhibitionupregulatesmhcitopotentiatecytotoxictlymphocyteresponsesinbreastcancer AT feiliu dnamethyltransferaseinhibitionupregulatesmhcitopotentiatecytotoxictlymphocyteresponsesinbreastcancer AT mohammedntantawy dnamethyltransferaseinhibitionupregulatesmhcitopotentiatecytotoxictlymphocyteresponsesinbreastcancer AT melindaesanders dnamethyltransferaseinhibitionupregulatesmhcitopotentiatecytotoxictlymphocyteresponsesinbreastcancer AT hcharlesmanning dnamethyltransferaseinhibitionupregulatesmhcitopotentiatecytotoxictlymphocyteresponsesinbreastcancer AT justinmbalko dnamethyltransferaseinhibitionupregulatesmhcitopotentiatecytotoxictlymphocyteresponsesinbreastcancer
_version_	1718380652151177216

DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer

Ejemplares similares