Synergy between repellents and organophosphates on bed nets: efficacy and behavioural response of natural free-flying An. gambiae mosquitoes.

<h4>Background</h4>Chemicals are used on bed nets in order to prevent infected bites and to kill aggressive malaria vectors. Because pyrethroid resistance has become widespread in the main malaria vectors, research for alternative active ingredients becomes urgent. Mixing a repellent and...

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Autores principales:	Cédric Pennetier, Carlo Costantini, Vincent Corbel, Séverine Licciardi, Roch K Dabiré, Bruno Lapied, Fabrice Chandre, Jean-Marc Hougard
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ffba11d9f50042f0bfba9d48d3bc2d2e
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spelling	oai:doaj.org-article:ffba11d9f50042f0bfba9d48d3bc2d2e2021-11-25T06:27:59ZSynergy between repellents and organophosphates on bed nets: efficacy and behavioural response of natural free-flying An. gambiae mosquitoes.1932-620310.1371/journal.pone.0007896https://doaj.org/article/ffba11d9f50042f0bfba9d48d3bc2d2e2009-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19936249/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Chemicals are used on bed nets in order to prevent infected bites and to kill aggressive malaria vectors. Because pyrethroid resistance has become widespread in the main malaria vectors, research for alternative active ingredients becomes urgent. Mixing a repellent and a non-pyrethroid insecticide seemed to be a promising tool as mixtures in the laboratory showed the same features as pyrethroids.<h4>Methodology/principal findings</h4>We present here the results of two trials run against free-flying Anopheles gambiae populations comparing the effects of two insect repellents (either DEET or KBR 3023, also known as icaridin) and an organophosphate insecticide at low-doses (pirimiphos-methyl, PM) used alone and in combination on bed nets. We showed that mixtures of PM and the repellents induced higher exophily, blood feeding inhibition and mortality among wild susceptible and resistant malaria vectors than compounds used alone. Nevertheless the synergistic interactions are only involved in the high mortality induced by the two mixtures.<h4>Conclusion</h4>These field trials argue in favour of the strategy of mixing repellent and organophosphate on bed nets to better control resistant malaria vectors.Cédric PennetierCarlo CostantiniVincent CorbelSéverine LicciardiRoch K DabiréBruno LapiedFabrice ChandreJean-Marc HougardPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 11, p e7896 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cédric Pennetier Carlo Costantini Vincent Corbel Séverine Licciardi Roch K Dabiré Bruno Lapied Fabrice Chandre Jean-Marc Hougard Synergy between repellents and organophosphates on bed nets: efficacy and behavioural response of natural free-flying An. gambiae mosquitoes.
description	<h4>Background</h4>Chemicals are used on bed nets in order to prevent infected bites and to kill aggressive malaria vectors. Because pyrethroid resistance has become widespread in the main malaria vectors, research for alternative active ingredients becomes urgent. Mixing a repellent and a non-pyrethroid insecticide seemed to be a promising tool as mixtures in the laboratory showed the same features as pyrethroids.<h4>Methodology/principal findings</h4>We present here the results of two trials run against free-flying Anopheles gambiae populations comparing the effects of two insect repellents (either DEET or KBR 3023, also known as icaridin) and an organophosphate insecticide at low-doses (pirimiphos-methyl, PM) used alone and in combination on bed nets. We showed that mixtures of PM and the repellents induced higher exophily, blood feeding inhibition and mortality among wild susceptible and resistant malaria vectors than compounds used alone. Nevertheless the synergistic interactions are only involved in the high mortality induced by the two mixtures.<h4>Conclusion</h4>These field trials argue in favour of the strategy of mixing repellent and organophosphate on bed nets to better control resistant malaria vectors.
format	article
author	Cédric Pennetier Carlo Costantini Vincent Corbel Séverine Licciardi Roch K Dabiré Bruno Lapied Fabrice Chandre Jean-Marc Hougard
author_facet	Cédric Pennetier Carlo Costantini Vincent Corbel Séverine Licciardi Roch K Dabiré Bruno Lapied Fabrice Chandre Jean-Marc Hougard
author_sort	Cédric Pennetier
title	Synergy between repellents and organophosphates on bed nets: efficacy and behavioural response of natural free-flying An. gambiae mosquitoes.
title_short	Synergy between repellents and organophosphates on bed nets: efficacy and behavioural response of natural free-flying An. gambiae mosquitoes.
title_full	Synergy between repellents and organophosphates on bed nets: efficacy and behavioural response of natural free-flying An. gambiae mosquitoes.
title_fullStr	Synergy between repellents and organophosphates on bed nets: efficacy and behavioural response of natural free-flying An. gambiae mosquitoes.
title_full_unstemmed	Synergy between repellents and organophosphates on bed nets: efficacy and behavioural response of natural free-flying An. gambiae mosquitoes.
title_sort	synergy between repellents and organophosphates on bed nets: efficacy and behavioural response of natural free-flying an. gambiae mosquitoes.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/ffba11d9f50042f0bfba9d48d3bc2d2e
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Synergy between repellents and organophosphates on bed nets: efficacy and behavioural response of natural free-flying An. gambiae mosquitoes.

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