Patterns of genomic evolution in advanced melanoma

As melanoma progresses, it evolves. Here, in advanced melanoma the authors study genomic evolution, highlighting trunk mutations dominated by the ultraviolet damage signature, common late truncal whole-genome duplication events, as well as selective copy number gain of mutant BRAF.

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Detalles Bibliográficos
Autores principales:	E. Birkeland, S. Zhang, D. Poduval, J. Geisler, S. Nakken, D. Vodak, L. A. Meza-Zepeda, E. Hovig, O. Myklebost, S. Knappskog, P. E. Lønning
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ffbb2b2a90434988a7693775c83b0b50
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spelling	oai:doaj.org-article:ffbb2b2a90434988a7693775c83b0b502021-12-02T15:33:54ZPatterns of genomic evolution in advanced melanoma10.1038/s41467-018-05063-12041-1723https://doaj.org/article/ffbb2b2a90434988a7693775c83b0b502018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05063-1https://doaj.org/toc/2041-1723As melanoma progresses, it evolves. Here, in advanced melanoma the authors study genomic evolution, highlighting trunk mutations dominated by the ultraviolet damage signature, common late truncal whole-genome duplication events, as well as selective copy number gain of mutant BRAF.E. BirkelandS. ZhangD. PoduvalJ. GeislerS. NakkenD. VodakL. A. Meza-ZepedaE. HovigO. MyklebostS. KnappskogP. E. LønningNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q E. Birkeland S. Zhang D. Poduval J. Geisler S. Nakken D. Vodak L. A. Meza-Zepeda E. Hovig O. Myklebost S. Knappskog P. E. Lønning Patterns of genomic evolution in advanced melanoma
description	As melanoma progresses, it evolves. Here, in advanced melanoma the authors study genomic evolution, highlighting trunk mutations dominated by the ultraviolet damage signature, common late truncal whole-genome duplication events, as well as selective copy number gain of mutant BRAF.
format	article
author	E. Birkeland S. Zhang D. Poduval J. Geisler S. Nakken D. Vodak L. A. Meza-Zepeda E. Hovig O. Myklebost S. Knappskog P. E. Lønning
author_facet	E. Birkeland S. Zhang D. Poduval J. Geisler S. Nakken D. Vodak L. A. Meza-Zepeda E. Hovig O. Myklebost S. Knappskog P. E. Lønning
author_sort	E. Birkeland
title	Patterns of genomic evolution in advanced melanoma
title_short	Patterns of genomic evolution in advanced melanoma
title_full	Patterns of genomic evolution in advanced melanoma
title_fullStr	Patterns of genomic evolution in advanced melanoma
title_full_unstemmed	Patterns of genomic evolution in advanced melanoma
title_sort	patterns of genomic evolution in advanced melanoma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ffbb2b2a90434988a7693775c83b0b50
work_keys_str_mv	AT ebirkeland patternsofgenomicevolutioninadvancedmelanoma AT szhang patternsofgenomicevolutioninadvancedmelanoma AT dpoduval patternsofgenomicevolutioninadvancedmelanoma AT jgeisler patternsofgenomicevolutioninadvancedmelanoma AT snakken patternsofgenomicevolutioninadvancedmelanoma AT dvodak patternsofgenomicevolutioninadvancedmelanoma AT lamezazepeda patternsofgenomicevolutioninadvancedmelanoma AT ehovig patternsofgenomicevolutioninadvancedmelanoma AT omyklebost patternsofgenomicevolutioninadvancedmelanoma AT sknappskog patternsofgenomicevolutioninadvancedmelanoma AT pelønning patternsofgenomicevolutioninadvancedmelanoma
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Patterns of genomic evolution in advanced melanoma

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