New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1

New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1

Tyrosyl-DNA phosphodiesterase 1 (TDP1) catalyzes the cleavage of the phosphodiester bond between the tyrosine residue of topoisomerase 1 (TOP1) and the 3′ phosphate of DNA in the single-strand break generated by TOP1. TDP1 promotes the cleavage of the stable DNA–TOP1 complexes with the TOP1 inhibito...

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Autores principales: Nadezhda S. Dyrkheeva, Aleksandr S. Filimonov, Olga A. Luzina, Kristina A. Orlova, Irina A. Chernyshova, Tatyana E. Kornienko, Anastasia A. Malakhova, Sergey P. Medvedev, Alexandra L. Zakharenko, Ekaterina S. Ilina, Rashid O. Anarbaev, Konstantin N. Naumenko, Kristina V. Klabenkova, Ekaterina A. Burakova, Dmitry A. Stetsenko, Suren M. Zakian, Nariman F. Salakhutdinov, Olga I. Lavrik
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
usnic acid
thioether
tyrosyl-DNA phosphodiesterase 1
TDP1 inhibitor
inhibiting activity
TDP2
Biology (General)
QH301-705.5
Chemistry
QD1-999
Acceso en línea:https://doaj.org/article/ffbea489293848d98465c39d785114bf
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