Suspected acquired narcolepsy in 8 dogs

Abstract Background Acquired narcolepsy has rarely been reported in veterinary medicine. Objective To describe the presentation, clinicopathological features, diagnostic imaging findings, and management of dogs with suspected‐acquired narcolepsy. Animals Eight dogs with clinical features consistent...

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Autores principales:	Koen M. Santifort, Edward J. Ives, Joe Fenn, Francesca Raimondi, Filipa Lourinho, Paul J. J. Mandigers, Niklas Bergknut
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	French Bulldog hypocretin meningoencephalitis sleep disorder symptomatic narcolepsy Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/ffbebc7217dc40e585f630787210d5eb
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spelling	oai:doaj.org-article:ffbebc7217dc40e585f630787210d5eb2021-11-30T17:01:04ZSuspected acquired narcolepsy in 8 dogs1939-16760891-664010.1111/jvim.16116https://doaj.org/article/ffbebc7217dc40e585f630787210d5eb2021-05-01T00:00:00Zhttps://doi.org/10.1111/jvim.16116https://doaj.org/toc/0891-6640https://doaj.org/toc/1939-1676Abstract Background Acquired narcolepsy has rarely been reported in veterinary medicine. Objective To describe the presentation, clinicopathological features, diagnostic imaging findings, and management of dogs with suspected‐acquired narcolepsy. Animals Eight dogs with clinical features consistent with acquired narcolepsy. Methods A call for suspected cases of acquired narcolepsy was made online, followed by a retrospective review of detailed medical records of potential cases. Dogs were included if episodes consistent with cataplexy were present during examination by a board‐certified veterinary neurologist and diagnostic work‐up included magnetic resonance imaging of the brain and analysis of cerebrospinal fluid. Results Seven French Bulldogs and 1 Chihuahua (age range, 9‐66 months) were included. Meningoencephalitis of unknown origin was diagnosed in 2 dogs, extracranial foci of inflammation were identified in 2 dogs (aspiration pneumonia, esophagitis, otitis media), and no abnormalities were found on diagnostic investigations in 4 dogs. Prednisolone was used in the management of all dogs, 6 dogs received imipramine, and 2 received cytosine arabinoside. An initial remission of signs was observed in all dogs, but a subsequent relapse of clinical signs was recorded for 4 dogs, of which 3 responded to adjustment or resumption of treatment. Conclusions and Clinical Importance The presence of cataplexy episodes should prompt a thorough diagnostic work‐up to exclude the presence of intracranial (and extracranial) pathology. The potential for both remission and relapse of signs in suspected acquired cases is important for clinicians and owners to be aware of.Koen M. SantifortEdward J. IvesJoe FennFrancesca RaimondiFilipa LourinhoPaul J. J. MandigersNiklas BergknutWileyarticleFrench Bulldoghypocretinmeningoencephalitissleep disordersymptomatic narcolepsyVeterinary medicineSF600-1100ENJournal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1448-1454 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	French Bulldog hypocretin meningoencephalitis sleep disorder symptomatic narcolepsy Veterinary medicine SF600-1100
spellingShingle	French Bulldog hypocretin meningoencephalitis sleep disorder symptomatic narcolepsy Veterinary medicine SF600-1100 Koen M. Santifort Edward J. Ives Joe Fenn Francesca Raimondi Filipa Lourinho Paul J. J. Mandigers Niklas Bergknut Suspected acquired narcolepsy in 8 dogs
description	Abstract Background Acquired narcolepsy has rarely been reported in veterinary medicine. Objective To describe the presentation, clinicopathological features, diagnostic imaging findings, and management of dogs with suspected‐acquired narcolepsy. Animals Eight dogs with clinical features consistent with acquired narcolepsy. Methods A call for suspected cases of acquired narcolepsy was made online, followed by a retrospective review of detailed medical records of potential cases. Dogs were included if episodes consistent with cataplexy were present during examination by a board‐certified veterinary neurologist and diagnostic work‐up included magnetic resonance imaging of the brain and analysis of cerebrospinal fluid. Results Seven French Bulldogs and 1 Chihuahua (age range, 9‐66 months) were included. Meningoencephalitis of unknown origin was diagnosed in 2 dogs, extracranial foci of inflammation were identified in 2 dogs (aspiration pneumonia, esophagitis, otitis media), and no abnormalities were found on diagnostic investigations in 4 dogs. Prednisolone was used in the management of all dogs, 6 dogs received imipramine, and 2 received cytosine arabinoside. An initial remission of signs was observed in all dogs, but a subsequent relapse of clinical signs was recorded for 4 dogs, of which 3 responded to adjustment or resumption of treatment. Conclusions and Clinical Importance The presence of cataplexy episodes should prompt a thorough diagnostic work‐up to exclude the presence of intracranial (and extracranial) pathology. The potential for both remission and relapse of signs in suspected acquired cases is important for clinicians and owners to be aware of.
format	article
author	Koen M. Santifort Edward J. Ives Joe Fenn Francesca Raimondi Filipa Lourinho Paul J. J. Mandigers Niklas Bergknut
author_facet	Koen M. Santifort Edward J. Ives Joe Fenn Francesca Raimondi Filipa Lourinho Paul J. J. Mandigers Niklas Bergknut
author_sort	Koen M. Santifort
title	Suspected acquired narcolepsy in 8 dogs
title_short	Suspected acquired narcolepsy in 8 dogs
title_full	Suspected acquired narcolepsy in 8 dogs
title_fullStr	Suspected acquired narcolepsy in 8 dogs
title_full_unstemmed	Suspected acquired narcolepsy in 8 dogs
title_sort	suspected acquired narcolepsy in 8 dogs
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/ffbebc7217dc40e585f630787210d5eb
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Suspected acquired narcolepsy in 8 dogs

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