A large size-selective DNA nanopore with sensing applications

Artificial nanopores can perform selective gating of molecules analogous to transmembrane proteins. Here, the authors design a DNA origami pore with a controllable lid for size-selective gating and translocation of macromolecules and evaluate its biosensing properties by single particle assay.

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Detalles Bibliográficos
Autores principales: Rasmus P. Thomsen, Mette Galsgaard Malle, Anders Hauge Okholm, Swati Krishnan, Søren S.-R. Bohr, Rasmus Schøler Sørensen, Oliver Ries, Stefan Vogel, Friedrich C. Simmel, Nikos S. Hatzakis, Jørgen Kjems
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/ffbfe203a3124a59974af877ed67471a
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Sumario:Artificial nanopores can perform selective gating of molecules analogous to transmembrane proteins. Here, the authors design a DNA origami pore with a controllable lid for size-selective gating and translocation of macromolecules and evaluate its biosensing properties by single particle assay.