Unmet needs of patients with narcolepsy: perspectives on emerging treatment options

Dariusz R Wozniak, Timothy G Quinnell Respiratory Support and Sleep Centre, Papworth Hospital, Cambridge, UK Abstract: The treatment options currently available for narcolepsy are often unsatisfactory due to suboptimal efficacy, troublesome side effects, development of drug tolerance, and inconveni...

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Autores principales:	Wozniak DR, Quinnell TG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/ffc2b855c8ab4f20aa34817e9e2d9856
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spelling	oai:doaj.org-article:ffc2b855c8ab4f20aa34817e9e2d98562021-12-02T02:55:47ZUnmet needs of patients with narcolepsy: perspectives on emerging treatment options1179-1608https://doaj.org/article/ffc2b855c8ab4f20aa34817e9e2d98562015-05-01T00:00:00Zhttp://www.dovepress.com/unmet-needs-of-patients-with-narcolepsy-perspectives-on-emerging-treat-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Dariusz R Wozniak, Timothy G Quinnell Respiratory Support and Sleep Centre, Papworth Hospital, Cambridge, UK Abstract: The treatment options currently available for narcolepsy are often unsatisfactory due to suboptimal efficacy, troublesome side effects, development of drug tolerance, and inconvenience. Our understanding of the neurobiology of narcolepsy has greatly improved over the last decade. This knowledge has not yet translated into additional therapeutic options for patients, but progress is being made. Some compounds, such as histaminergic H3 receptor antagonists, may prove useful in symptom control of narcolepsy. The prospect of finding a cure still seems distant, but hypocretin replacement therapy offers some promise. In this narrative review, we describe these developments and others which may yield more effective narcolepsy treatments in the future. Keywords: cataplexy, hypocretin, H3 antagonist, GABA-B agonists, immunotherapy Wozniak DRQuinnell TGDove Medical PressarticlePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2015, Iss default, Pp 51-61 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Wozniak DR Quinnell TG Unmet needs of patients with narcolepsy: perspectives on emerging treatment options
description	Dariusz R Wozniak, Timothy G Quinnell Respiratory Support and Sleep Centre, Papworth Hospital, Cambridge, UK Abstract: The treatment options currently available for narcolepsy are often unsatisfactory due to suboptimal efficacy, troublesome side effects, development of drug tolerance, and inconvenience. Our understanding of the neurobiology of narcolepsy has greatly improved over the last decade. This knowledge has not yet translated into additional therapeutic options for patients, but progress is being made. Some compounds, such as histaminergic H3 receptor antagonists, may prove useful in symptom control of narcolepsy. The prospect of finding a cure still seems distant, but hypocretin replacement therapy offers some promise. In this narrative review, we describe these developments and others which may yield more effective narcolepsy treatments in the future. Keywords: cataplexy, hypocretin, H3 antagonist, GABA-B agonists, immunotherapy
format	article
author	Wozniak DR Quinnell TG
author_facet	Wozniak DR Quinnell TG
author_sort	Wozniak DR
title	Unmet needs of patients with narcolepsy: perspectives on emerging treatment options
title_short	Unmet needs of patients with narcolepsy: perspectives on emerging treatment options
title_full	Unmet needs of patients with narcolepsy: perspectives on emerging treatment options
title_fullStr	Unmet needs of patients with narcolepsy: perspectives on emerging treatment options
title_full_unstemmed	Unmet needs of patients with narcolepsy: perspectives on emerging treatment options
title_sort	unmet needs of patients with narcolepsy: perspectives on emerging treatment options
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/ffc2b855c8ab4f20aa34817e9e2d9856
work_keys_str_mv	AT wozniakdr unmetneedsofpatientswithnarcolepsyperspectivesonemergingtreatmentoptions AT quinnelltg unmetneedsofpatientswithnarcolepsyperspectivesonemergingtreatmentoptions
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Unmet needs of patients with narcolepsy: perspectives on emerging treatment options

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