The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility

The factors that limit the nutrient flexibility of cells remain largely unknown. Here, the authors identify the glutamate/cysteine antiporter xCT in a genetic screen for glucose dependency and show it determines the ability of cells to survive under conditions of low glucose by limiting the utilizat...

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Autores principales:	Chun-Shik Shin, Prashant Mishra, Jeramie D. Watrous, Valerio Carelli, Marilena D’Aurelio, Mohit Jain, David C. Chan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ffc32426233347f1b087b7734c74c44d
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spelling	oai:doaj.org-article:ffc32426233347f1b087b7734c74c44d2021-12-02T15:38:59ZThe glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility10.1038/ncomms150742041-1723https://doaj.org/article/ffc32426233347f1b087b7734c74c44d2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15074https://doaj.org/toc/2041-1723The factors that limit the nutrient flexibility of cells remain largely unknown. Here, the authors identify the glutamate/cysteine antiporter xCT in a genetic screen for glucose dependency and show it determines the ability of cells to survive under conditions of low glucose by limiting the utilization of glutamine.Chun-Shik ShinPrashant MishraJeramie D. WatrousValerio CarelliMarilena D’AurelioMohit JainDavid C. ChanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chun-Shik Shin Prashant Mishra Jeramie D. Watrous Valerio Carelli Marilena D’Aurelio Mohit Jain David C. Chan The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
description	The factors that limit the nutrient flexibility of cells remain largely unknown. Here, the authors identify the glutamate/cysteine antiporter xCT in a genetic screen for glucose dependency and show it determines the ability of cells to survive under conditions of low glucose by limiting the utilization of glutamine.
format	article
author	Chun-Shik Shin Prashant Mishra Jeramie D. Watrous Valerio Carelli Marilena D’Aurelio Mohit Jain David C. Chan
author_facet	Chun-Shik Shin Prashant Mishra Jeramie D. Watrous Valerio Carelli Marilena D’Aurelio Mohit Jain David C. Chan
author_sort	Chun-Shik Shin
title	The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
title_short	The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
title_full	The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
title_fullStr	The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
title_full_unstemmed	The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
title_sort	glutamate/cystine xct antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ffc32426233347f1b087b7734c74c44d
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The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility

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